• 1. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
• 2. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 3. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584

Exploring 3-Aminocyclopentane-1-carboxylic Acid Hydrochloride (CAS No. 1203306-05-1): Properties, Applications, and Market Insights

3-Aminocyclopentane-1-carboxylic acid hydrochloride (CAS No. 1203306-05-1) is a specialized organic compound that has garnered significant attention in pharmaceutical and biochemical research. This compound, characterized by its cyclopentane backbone and functional groups, serves as a versatile building block in drug discovery and development. Its unique structure, combining an amino group and a carboxylic acid moiety, makes it valuable for synthesizing peptidomimetics and other bioactive molecules.

The molecular formula of 3-aminocyclopentane-1-carboxylic acid hydrochloride is C₆H₁₂ClNO₂, with a molecular weight of 165.62 g/mol. Its hydrochloride salt form enhances solubility, making it particularly useful in aqueous-based reactions. Researchers often seek this compound for its role in creating constrained amino acid analogs, which are critical in designing peptides with improved stability and bioavailability. Recent trends in drug discovery highlight the growing demand for such analogs to overcome challenges like enzymatic degradation and poor membrane permeability.

One of the most compelling applications of CAS 1203306-05-1 lies in the development of central nervous system (CNS) therapeutics. Its cyclopentane ring mimics natural amino acids while introducing conformational rigidity, a property highly sought after in targeting neurological receptors. With the rising prevalence of neurodegenerative diseases, the pharmaceutical industry is increasingly exploring 3-aminocyclopentane derivatives as potential candidates for treating conditions like Alzheimer's and Parkinson's disease.

From a synthetic chemistry perspective, 3-aminocyclopentane-1-carboxylic acid HCl offers several advantages. Its stereochemistry allows for the creation of enantiomerically pure compounds, which is crucial for achieving selective biological activity. The compound's compatibility with standard peptide coupling reagents, such as HBTU and HATU, further expands its utility in solid-phase peptide synthesis (SPPS). These features align with the current industry focus on precision medicine and personalized therapeutics.

The market for pharmaceutical intermediates like 1203306-05-1 has seen steady growth, driven by increased R&D investment in peptide-based drugs. Analysts project particular demand in the oncological peptide segment, where constrained amino acids play a pivotal role in developing targeted therapies. Furthermore, the compound's application in bioconjugation chemistry positions it as a valuable tool for creating antibody-drug conjugates (ADCs), one of the fastest-growing classes of biopharmaceuticals.

Quality control of 3-aminocyclopentane-1-carboxylic acid hydrochloride typically involves HPLC analysis to ensure high purity (>98%), which is essential for reproducible research outcomes. Storage recommendations usually suggest keeping the compound at 2-8°C in a dry environment to maintain stability. These specifications make it particularly suitable for high-throughput screening platforms and combinatorial chemistry approaches that dominate modern drug discovery workflows.

Environmental and safety considerations for CAS 1203306-05-1 follow standard laboratory chemical handling protocols. While not classified as hazardous under most regulatory frameworks, proper personal protective equipment (PPE) including gloves and safety glasses is recommended during handling. The compound's increasing appearance in green chemistry initiatives reflects the pharmaceutical industry's commitment to sustainable synthetic methodologies.

Recent patent literature reveals growing intellectual property activity surrounding cyclopentane-based amino acid derivatives, with particular emphasis on their use in GPCR-targeted drugs. This trend underscores the compound's relevance in addressing current therapeutic challenges, especially in areas like metabolic disorders and inflammation. The adaptability of 3-aminocyclopentane-1-carboxylic acid hydrochloride in structure-activity relationship (SAR) studies makes it a favorite among medicinal chemists working on next-generation therapeutics.

For researchers sourcing 1203306-05-1, verification of chiral purity and salt content is crucial, as these parameters significantly impact experimental outcomes. Reputable suppliers typically provide comprehensive analytical data including ¹H NMR, ¹³C NMR, and mass spectrometry results. The compound's role in developing macrocyclic peptides—a hot topic in current pharmaceutical research—further enhances its market position and scientific importance.

In conclusion, 3-aminocyclopentane-1-carboxylic acid hydrochloride (CAS No. 1203306-05-1) represents a sophisticated tool in modern medicinal chemistry. Its applications span from peptide drug development to bioconjugation strategies, addressing some of the most pressing challenges in contemporary therapeutics. As the demand for innovative drug modalities continues to rise, this compound's significance in pharmaceutical research is poised for further growth, making it a subject worthy of continued scientific and commercial attention.

• 71830-07-4((1S,3R)-3-aminocyclopentane-1-carboxylic acid)
• 19042-34-3((-)-(1r,3s)-3-aminocyclopentanecarboxylic acid)
• 27960-59-4(trans-4-aminocyclohexane-1-carboxylic acid hydrochloride)
• 19297-28-0(trans-3-Aminocyclopentanecarboxylic acid)
• 71830-08-5((1R,3S)-3-Aminocyclopentanecarboxylic acid)
• 49805-32-5(rac-(1R,3S)-3-aminocyclopentane-1-carboxylic acid)
• 57376-72-4(Cyclopentanecarboxylicacid, 3-amino-, (1R,3R)-rel-)
• 89614-96-0(3-aminocyclopentane-1-carboxylic acid)
• 71376-02-8((1S,3S)-3-aminocyclopentane-1-carboxylic acid)
• 71869-43-7((1R,3R)-3-aminocyclopentane-1-carboxylic acid)