Cas no 1201657-24-0 (4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine)

4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine is a fluorinated pyrimidine derivative with significant utility in pharmaceutical and agrochemical research. Its key structural features—a chloro substituent at the 4-position and a trifluoromethyl group at the 5-position—enhance its reactivity and stability, making it a versatile intermediate for nucleophilic substitution and cross-coupling reactions. The presence of the trifluoromethyl group improves lipophilicity and metabolic resistance, which is advantageous in drug design. This compound is particularly valuable in the synthesis of biologically active molecules, including kinase inhibitors and antimicrobial agents. Its high purity and well-defined reactivity profile ensure consistent performance in synthetic applications.
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine structure
1201657-24-0 structure
Product Name:4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
CAS No:1201657-24-0
MF:C5H3ClF3N3
MW:197.545629739761
MDL:MFCD20694893
CID:1090564
PubChem ID:21923110
Update Time:2025-05-20

4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine Chemical and Physical Properties

Names and Identifiers

    • 4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
    • DTXSID10620157
    • P12844
    • 1201657-24-0
    • 2-amino-4-chloro-5-trifluoromethylpyrimidine
    • 2-Pyrimidinamine, 4-chloro-5-(trifluoromethyl)-
    • SCHEMBL148812
    • AS-51517
    • CS-0050923
    • 2-Amino-4-chloro-5-(trifluoromethyl)pyrimidine
    • BYB65724
    • AKOS022176088
    • DB-218845
    • SY270260
    • MFCD20694893
    • SB16108
    • MDL： MFCD20694893
    • Inchi： 1S/C5H3ClF3N3/c6-3-2(5(7,8)9)1-11-4(10)12-3/h1H,(H2,10,11,12)
    • InChI Key： UWPIJBRPRPTDTI-UHFFFAOYSA-N
    • SMILES： ClC1C(=CN=C(N)N=1)C(F)(F)F

Computed Properties

  • Exact Mass: 196.9967593g/mol
  • Monoisotopic Mass: 196.9967593g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 163
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.7
  • Topological Polar Surface Area: 51.8?2

4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
C597388-10mg
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0
10mg
 $ 70.00 2022-06-06
TRC
C597388-50mg
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0
50mg
 $ 250.00 2022-06-06
TRC
C597388-100mg
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0
100mg
 $ 365.00 2022-06-06
Chemenu
CM167067-1g
4-chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0 95%
1g
 $998 2021-08-05
abcr
AB458768-1 g
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine, 95%; .
 1201657-24-0 95%
1g
 €884.50 2023-04-22
Ambeed
A125964-100mg
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0 98%
100mg
 $136.0 2024-04-25
Ambeed
A125964-250mg
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0 98%
250mg
 $208.0 2024-04-25
Ambeed
A125964-1g
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0 98%
1g
 $545.0 2024-04-25
Ambeed
A125964-5g
4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0 98%
5g
 $1906.0 2024-04-25
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBLJ3400-100mg
4-chloro-5-(trifluoromethyl)pyrimidin-2-amine
 1201657-24-0 97%
100mg
 ￥937.0 2024-04-25

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