• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 3. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 4. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 5. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines Sulfonylanilines

4-Methanesulfonyl-N-methylaniline: A Comprehensive Overview

The compound 4-Methanesulfonyl-N-methylaniline, identified by the CAS number 119871-25-9, is a significant molecule in the field of organic chemistry. This compound is characterized by its unique structure, which combines a methanesulfonyl group with an N-methyl substituent on an aniline backbone. The methanesulfonyl group, also known as a mesyl group, is a strong electron-withdrawing group, which imparts specific reactivity and properties to the molecule. The N-methyl substitution further modifies the electronic and steric characteristics of the compound, making it versatile for various applications in research and industry.

Recent studies have highlighted the importance of 4-Methanesulfonyl-N-methylaniline in drug discovery and materials science. In pharmacology, this compound has been explored as a potential lead molecule due to its ability to interact with specific biological targets. Researchers have investigated its role in modulating enzyme activity and its potential as a ligand in receptor-based drug design. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit promising inhibitory effects on kinase enzymes, which are critical in cancer signaling pathways.

In terms of synthesis, 4-Methanesulfonyl-N-methylaniline can be prepared through several routes, including nucleophilic aromatic substitution and coupling reactions. One common method involves the reaction of aniline derivatives with methanesulfonyl chloride in the presence of a base. The choice of substituents and reaction conditions significantly influences the yield and purity of the final product. Advanced techniques such as microwave-assisted synthesis have been employed to optimize reaction efficiency, as reported in a 2023 article in Green Chemistry.

The application of 4-Methanesulfonyl-N-methylaniline extends beyond pharmacology into materials science. Its electron-withdrawing properties make it a valuable component in the development of advanced materials, such as high-performance polymers and electronic devices. For example, researchers have utilized this compound as a building block for constructing functional polymers with tailored electronic properties. A 2023 study in Macromolecules showcased its use in creating conductive polymers for flexible electronics.

In addition to its chemical applications, 4-Methanesulfonyl-N-methylaniline has been studied for its environmental impact. Assessments of its biodegradation and toxicity profiles are essential for ensuring safe handling and disposal. Recent eco-toxicological studies indicate that while the compound exhibits moderate toxicity to aquatic organisms, its environmental footprint can be minimized through proper waste management practices.

The future prospects for 4-Methanesulfonyl-N-methylaniline are promising, driven by ongoing research into its structural modifications and functional applications. Collaborative efforts between chemists, biologists, and engineers are expected to unlock new potentials for this compound in diverse fields such as nanotechnology and green chemistry.

• 33871-62-4(Benzenamine,4,4'-sulfonylbis[N,N-dimethyl-)
• 3572-34-7(Benzenamine,4-[(4-aminophenyl)sulfonyl]-N-ethyl-)
• 61654-48-6(Benzenamine, N-phenyl-4-(phenylsulfonyl)-)
• 51688-26-7(Benzenamine, 4-[(4-aminophenyl)sulfonyl]-N-methyl-)
• 35216-39-8(3-(Methanesulfonyl)aniline)
• 17051-85-3(Methanediamine,N,N'-bis(p-sulfanilylphenyl)- (8CI))
• 5470-49-5(4-methanesulfonylaniline)
• 177662-76-9(4-methylsulfonylaniline;hydrochloride)
• 15979-81-4(Benzenamine,4-(methylsulfonyl)-N-phenyl-)
• 62489-12-7(Benzenamine, 4-[[4-(phenylsulfonyl)phenyl]sulfonyl]-)