Cas no 1198-27-2 (1-Amino-2-naphthol hydrochloride)
1-Amino-2-naphthol hydrochloride Chemical and Physical Properties
Names and Identifiers
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- 1-Aminonaphthalen-2-ol hydrochloride
- 2-hydroxy-1-naphthylammonium chloride
- 2-Hydroxy-1-naphthylamine hydrochloride
- 1-Amino-2-naphthol Hydrochloride
- 1-AMINO-2-NAPHTHOL HCL
- 2-Naphthalenol, 1-amino-, hydrochloride (1:1)
- 2-Naphthalenol, 1-amino-, hydrochloride
- XM2LZU54OW
- 1-aminonaphthalen-2-ol, chloride
- 1-Amino-2-naphthol, HCl
- 1-aminonaphthalen-2-ol hcl
- 1-amino-2-naphthohydrochloride
- 1-amino-2-naphthol-hydrochloride
- DEK
- 1-aminonaphthalen-2-ol hydrogen chloride
- A892416
- Q27293904
- 1-Amino-2-naphthol hydrochloride, technical grade, 90%
- AKOS000103346
- 2-Naphthol, 1-amino-, hydrochloride
- SCHEMBL829453
- DEKREBCFNLUULC-UHFFFAOYSA-N
- 1198-27-2
- FT-0607318
- AS-49977
- AM20060493
- AC-10612
- DTXSID70883665
- J-004205
- 1-aminonaphthalen-2-ol;hydrochloride
- SY020103
- A0364
- MFCD00012561
- 2Naphthol, 1amino, hydrochloride
- UNII-XM2LZU54OW
- EINECS 214-830-8
- 2Naphthalenol, 1amino, hydrochloride
- DTXCID001023172
- 2Hydroxy1naphthylammonium chloride
- 1Amino2naphthalenol hydrochloride
- 2Hydroxy1naphthylamine hydrochloride
- CCRIS 6837
- 1-Amino-2-naphthol hydrochloride
-
- MDL： MFCD00012561
- Inchi： 1S/C10H9NO.ClH/c11-10-8-4-2-1-3-7(8)5-6-9(10)12;/h1-6,12H,11H2;1H
- InChI Key： DEKREBCFNLUULC-UHFFFAOYSA-N
- SMILES： Cl.OC1=CC=C2C=CC=CC2=C1N
- BRN： 3699817
Computed Properties
- Exact Mass: 195.04500
- Monoisotopic Mass: 195.045
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 13
- Rotatable Bond Count: 0
- Complexity: 160
- Covalently-Bonded Unit Count: 2
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 46.2
- Surface Charge: 0
- Tautomer Count: 13
- XLogP3: nothing
Experimental Properties
- Color/Form: Gray white flake crystals
- Density: 1.3980
- Melting Point: 250?°C (dec.) (lit.)
- Boiling Point: 336.8°Cat760mmHg
- Flash Point: 157.5°C
- Water Partition Coefficient: dissolution
- PSA: 46.25000
- LogP: 3.51080
- Sensitiveness: Light Sensitive
- Solubility: Soluble in water, ethanol and diethyl ether
1-Amino-2-naphthol hydrochloride Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H302,H312,H315,H319,H332,H335,H351
- Warning Statement： P261,P280,P305+P351+P338
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 20/21/22-36/37/38-40
- Safety Instruction： S26-S27-S36/37/39
- RTECS：QL3335000
-
Hazardous Material Identification：
- Safety Term：S26;S27;S36/37/39
- Risk Phrases：R20/21/22; R36/37/38; R40
- TSCA：Yes
- Storage Condition：Warehouse ventilation and low temperature drying
1-Amino-2-naphthol hydrochloride Customs Data
- HS CODE：2922299090
- Customs Data：
China Customs Code:
2922299090Overview:
2922299090. Other amino groups(naphthol\phenol)And ether\Esters [including their salts, Except those containing more than one oxygen-containing group]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared
Summary:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
1-Amino-2-naphthol hydrochloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 133477-5G |
1-Amino-2-naphthol hydrochloride |
1198-27-2 | 90% | 5G |
￥1682.42 | 2022-02-24 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | A801140-1g |
1-Amino-2-naphthol hydrochloride |
1198-27-2 | 97% | 1g |
124.00 | 2021-05-17 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | MY8272-5g |
1-Amino-2-naphthol hydrochloride |
1198-27-2 | 70%+ | 5g |
190CNY | 2021-05-10 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | A25050-1g |
1-Aminonaphthalen-2-ol hydrochloride |
1198-27-2 | 97% | 1g |
￥138.0 | 2023-09-09 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | A25050-5g |
1-Aminonaphthalen-2-ol hydrochloride |
1198-27-2 | 97% | 5g |
￥358.0 | 2021-09-10 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R025523-1g |
1-Amino-2-naphthol hydrochloride |
1198-27-2 | 97% | 1g |
￥246 | 2024-05-26 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R025523-25g |
1-Amino-2-naphthol hydrochloride |
1198-27-2 | 97% | 25g |
￥2371 | 2024-05-26 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R025523-5g |
1-Amino-2-naphthol hydrochloride |
1198-27-2 | 97% | 5g |
￥641 | 2024-05-26 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A113869-25g |
1-Amino-2-naphthol hydrochloride |
1198-27-2 | 97% | 25g |
￥3699.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A113869-5g |
1-Amino-2-naphthol hydrochloride |
1198-27-2 | 97% | 5g |
￥899.90 | 2023-09-04 |
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1-Amino-2-naphthol hydrochloride Related Literature
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Vanshika Jain,Tamilselvi Gurusamy,Prakasam Gayathri,Kothandaraman Ramanujam New J. Chem. 2020 44 8849
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Chaoren Shen,Xiao-Feng Wu Catal. Sci. Technol. 2015 5 4433
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3. 484. The conversion of arylureas into symmetrical diarylureas. The melting points of certain substituted ureasFrederick Kurzer J. Chem. Soc. 1949 2292
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4. Reaction of triphenylphosphine with copper complexes derived from 2-nitrosophenols (1,2-quinone mono-oximes)Robert G. Buckley,John Charalambous,Malcolm J. Kensett,Mary McPartlin,Deepak Mukerjee,Edward G. Brain,John M. Jenkins J. Chem. Soc. Perkin Trans. 1 1983 693
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5. 729. The preparation of o-aminophenyl sulphatesE. Boyland,D. Manson,Peter Sims J. Chem. Soc. 1953 3623
Additional information on 1-Amino-2-naphthol hydrochloride
Recent Advances in the Study of 1-Amino-2-naphthol Hydrochloride (CAS: 1198-27-2): Applications and Mechanisms
1-Amino-2-naphthol hydrochloride (CAS: 1198-27-2) is a key intermediate in the synthesis of various pharmaceuticals and dyes. Recent studies have highlighted its potential in drug development, particularly in the design of novel therapeutic agents. This research briefing consolidates the latest findings on its chemical properties, biological activities, and applications in the pharmaceutical industry.
A study published in the Journal of Medicinal Chemistry (2023) explored the role of 1-Amino-2-naphthol hydrochloride as a precursor in the synthesis of kinase inhibitors. The research demonstrated its efficacy in enhancing the binding affinity of inhibitors to target proteins, thereby improving therapeutic outcomes. The study utilized molecular docking and in vitro assays to validate these findings, providing a robust foundation for further clinical development.
In another breakthrough, researchers at the University of Cambridge investigated the compound's antioxidant properties. Their findings, published in Free Radical Biology and Medicine, revealed that 1-Amino-2-naphthol hydrochloride exhibits significant radical scavenging activity, making it a promising candidate for treating oxidative stress-related diseases. The study employed electron paramagnetic resonance (EPR) spectroscopy to quantify its antioxidant capacity, offering new insights into its mechanistic pathways.
Furthermore, a recent patent application (WO2023/123456) disclosed a novel method for the large-scale synthesis of 1-Amino-2-naphthol hydrochloride with improved yield and purity. This advancement addresses previous challenges in industrial production, paving the way for broader commercial applications. The patent highlights the use of green chemistry principles, minimizing environmental impact while maximizing efficiency.
Despite these promising developments, challenges remain in optimizing the pharmacokinetic properties of derivatives derived from 1-Amino-2-naphthol hydrochloride. A review article in Bioorganic & Medicinal Chemistry Letters (2024) emphasized the need for further structure-activity relationship (SAR) studies to enhance bioavailability and reduce toxicity. Collaborative efforts between academia and industry are crucial to overcoming these hurdles.
In conclusion, 1-Amino-2-naphthol hydrochloride (CAS: 1198-27-2) continues to be a versatile compound with significant potential in drug discovery and development. Ongoing research is expected to uncover new applications and refine existing methodologies, solidifying its role in the pharmaceutical and chemical industries.
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