• 1. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 2. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
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• 3. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
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• 4. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 5. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

Professional Introduction to 3-Amino-4,6-difluoro-1H-indazole (CAS No. 1197193-24-0)

3-Amino-4,6-difluoro-1H-indazole, identified by the Chemical Abstracts Service Number (CAS No.) 1197193-24-0, is a fluorinated heterocyclic compound that has garnered significant attention in the field of pharmaceutical chemistry and medicinal biology due to its unique structural and electronic properties. This compound belongs to the indazole class, which is well-documented for its broad spectrum of biological activities, including antimicrobial, anti-inflammatory, and anticancer effects. The introduction of fluorine atoms at the 4 and 6 positions of the indazole ring enhances its pharmacological potential by modulating electronic effects, lipophilicity, and metabolic stability.

The structural motif of 3-amino-4,6-difluoro-1H-indazole consists of a benzene-like aromatic system fused with a nitrogen-containing five-membered ring. The presence of two fluorine substituents at the 4 and 6 positions introduces significant electron-withdrawing effects, which can influence the reactivity and binding affinity of the molecule towards biological targets. Additionally, the amino group at the 3-position provides a site for further functionalization, enabling the synthesis of more complex derivatives with tailored biological properties.

In recent years, there has been growing interest in fluorinated indazoles as pharmacophores due to their ability to improve drug-like properties such as bioavailability and resistance to enzymatic degradation. The fluorine atoms can enhance the metabolic stability of drug candidates by preventing unwanted hydrolysis or oxidation. Furthermore, fluorine substitution often leads to increased binding affinity to biological targets, making fluorinated compounds attractive for drug development.

One of the most compelling aspects of 3-amino-4,6-difluoro-1H-indazole is its potential as a building block for novel therapeutic agents. Researchers have explored its derivatives in various disease models, demonstrating promising results in preclinical studies. For instance, studies have shown that certain fluorinated indazoles exhibit potent inhibitory activity against kinases and other enzymes involved in cancer progression. The electron-withdrawing nature of the fluorine atoms at positions 4 and 6 can optimize the interactions between the compound and its target proteins, leading to enhanced efficacy.

The synthesis of 3-amino-4,6-difluoro-1H-indazole typically involves multi-step organic reactions that require careful control of reaction conditions to ensure high yield and purity. Common synthetic routes include nucleophilic substitution reactions on halogenated precursors followed by functional group transformations such as amination. Advanced techniques such as palladium-catalyzed cross-coupling reactions have also been employed to introduce fluorine atoms with high precision.

Recent advancements in computational chemistry have further accelerated the discovery process for fluorinated indazoles like 3-amino-4,6-difluoro-1H-indazole. Molecular modeling studies have helped researchers predict binding modes and optimize lead compounds before experimental synthesis. These computational approaches are particularly valuable for understanding how structural modifications affect biological activity.

The pharmacokinetic profile of 3-amino-4,6-difluoro-1H-indazole is another critical aspect that has been extensively studied. Fluorine substitution can influence solubility, permeability, and metabolic clearance rates, all of which are essential for drug development. Preclinical data suggest that this compound exhibits favorable pharmacokinetic properties in animal models, making it a promising candidate for further investigation.

In conclusion,3-amino-4,6-difluoro-1H-indazole (CAS No. 1197193-24-0) represents a significant advancement in pharmaceutical chemistry due to its unique structural features and potential therapeutic applications. The combination of fluorine substitution and an amino group provides a versatile scaffold for designing novel drugs with improved efficacy and stability. As research continues to uncover new biological activities and synthetic strategies for this class of compounds,3-amino-4,6-difluoro-1H-indazole is poised to play a crucial role in future drug development efforts.

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