• 1. Distributed research: a new paradigm for undergraduate research and global problem solving?
  Bruce Parkinson Energy Environ. Sci., 2010,3, 509-511
• 2. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 3. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267
• 4. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 5. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782

Introduction to 4-Bromo-3-Ethynylpyridine (CAS No. 1196146-05-0)

4-Bromo-3-ethynylpyridine (CAS No. 1196146-05-0) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique bromo and ethynyl functionalities, has shown promise in various applications, particularly in the synthesis of bioactive molecules and drug discovery.

The molecular structure of 4-bromo-3-ethynylpyridine consists of a pyridine ring with a bromine atom at the 4-position and an ethynyl group at the 3-position. The presence of these functional groups imparts distinct chemical properties, making it a valuable intermediate in synthetic pathways. The bromo group can serve as a leaving group in substitution reactions, while the ethynyl group can undergo various transformations, such as hydrolysis, reduction, and coupling reactions.

Recent studies have highlighted the potential of 4-bromo-3-ethynylpyridine in the development of novel therapeutic agents. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that this compound can be used as a key intermediate in the synthesis of potent inhibitors of protein kinases, which are implicated in various diseases, including cancer and inflammatory disorders. The ability to fine-tune the structure through functional group manipulation allows for the optimization of pharmacological properties, such as potency, selectivity, and bioavailability.

In addition to its role in medicinal chemistry, 4-bromo-3-ethynylpyridine has been explored for its applications in materials science. Research conducted at the University of California, Berkeley, revealed that this compound can be used to synthesize conjugated polymers with tunable electronic properties. These polymers have potential applications in organic electronics, such as organic field-effect transistors (OFETs) and organic photovoltaic (OPV) devices.

The synthetic accessibility of 4-bromo-3-ethynylpyridine is another factor contributing to its widespread use. Several efficient synthetic routes have been developed to produce this compound on both laboratory and industrial scales. One notable method involves the Sonogashira coupling reaction between 4-bromopyridine and an appropriate terminal alkyne, followed by deprotection if necessary. This method is highly versatile and can be adapted to incorporate various substituents on the pyridine ring or the ethynyl group.

The safety and environmental impact of 4-bromo-3-ethynylpyridine are also important considerations. While it is not classified as a hazardous material under current regulations, proper handling and storage practices should be followed to ensure workplace safety. It is recommended to use personal protective equipment (PPE) such as gloves and goggles when handling this compound to minimize exposure risks.

In conclusion, 4-bromo-3-ethynylpyridine (CAS No. 1196146-05-0) is a multifaceted compound with significant potential in both medicinal chemistry and materials science. Its unique chemical structure and synthetic versatility make it an invaluable tool for researchers aiming to develop novel therapeutic agents and advanced materials. As research continues to advance, it is likely that new applications for this compound will emerge, further solidifying its importance in the scientific community.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)