• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 3. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 4. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 5. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502

Comprehensive Overview of 3-(thiophen-3-yl)propan-1-amine (CAS No. 119451-18-2): Properties, Applications, and Industry Insights

3-(thiophen-3-yl)propan-1-amine (CAS No. 119451-18-2) is an organosulfur compound featuring a thiophene ring linked to a propylamine chain. This structurally unique molecule has garnered significant attention in pharmaceutical and materials science research due to its versatile reactivity and potential applications. The thiophene-amine hybrid structure enables diverse chemical modifications, making it valuable for designing novel drug candidates and functional materials.

Recent studies highlight the compound's role as a key intermediate in synthesizing biologically active molecules. Its electron-rich thiophene moiety contributes to interesting electronic properties, while the primary amine functionality allows for straightforward derivatization. Researchers particularly value its balanced lipophilicity and hydrogen-bonding capacity, which are crucial for medicinal chemistry applications. The compound's molecular weight of 141.23 g/mol and moderate polarity make it suitable for various synthetic transformations.

In pharmaceutical development, 3-(thiophen-3-yl)propan-1-amine serves as a versatile building block for CNS-targeting compounds. The thiophene ring's bioisosteric relationship with phenyl groups allows for optimized pharmacokinetic properties in drug candidates. Current research explores its incorporation into neuromodulators and enzyme inhibitors, with particular interest in its potential for treating neurological disorders—a trending topic in medicinal chemistry circles.

The material science applications of this compound are equally compelling. Its conjugated system enables participation in conducting polymer synthesis, relevant to organic electronics development. As the demand for flexible electronics and organic photovoltaics grows (hot topics in sustainable technology), researchers are investigating thiophene-containing amines like 119451-18-2 for their electron transport properties and film-forming capabilities.

From a synthetic chemistry perspective, the compound's amine protection strategies and selective functionalization methods represent active research areas. Recent publications describe innovative approaches to N-alkylation and amide formation while preserving the thiophene ring's integrity. These developments address common search queries about "amine group modifications in heterocyclic compounds" and "thiophene derivative synthesis."

Quality control of 3-(thiophen-3-yl)propan-1-amine typically involves HPLC analysis and spectroscopic characterization (IR, NMR, MS). The compound's stability profile shows good resistance to oxidation when stored properly, though like many amines, it requires protection from atmospheric moisture and carbon dioxide. These practical handling considerations frequently appear in laboratory technique discussions and chemical storage FAQs.

The commercial availability of CAS 119451-18-2 has expanded in recent years to meet growing research demand. Suppliers now offer various purity grades (98-99.5+%), with analytical certificates addressing common purchaser concerns about impurity profiles and batch-to-batch consistency—key factors for reproducible research results. Current market trends indicate increasing interest in custom derivatization services for this scaffold.

Environmental and safety assessments of thiophene-containing amines continue to evolve alongside regulatory standards. While not classified as hazardous under current systems, proper laboratory precautions apply during handling. This aligns with growing industry emphasis on green chemistry principles and sustainable synthetic routes—topics generating substantial search traffic among chemistry professionals.

Future research directions for 3-(thiophen-3-yl)propan-1-amine likely include expanded investigations into its catalytic applications and supramolecular chemistry potential. The compound's ability to participate in both coordination chemistry (via the amine) and π-stacking interactions (through the thiophene) makes it particularly interesting for designing multifunctional materials. These applications resonate with current scientific interest in smart materials and molecular machines.

In summary, 3-(thiophen-3-yl)propan-1-amine (CAS No. 119451-18-2) represents a valuable chemical entity bridging pharmaceutical and materials science domains. Its structural features enable diverse applications that align with several cutting-edge research trends, from neurological drug discovery to organic electronic materials development. As synthetic methodologies advance and application research deepens, this compound will likely maintain its relevance across multiple scientific disciplines.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)