Cas no 1192548-07-4 (1-Bromo-3-nitro-2-(trifluoromethyl)Benzene)

1-Bromo-3-nitro-2-(trifluoromethyl)benzene is a halogenated aromatic compound featuring a bromo substituent at the 1-position, a nitro group at the 3-position, and a trifluoromethyl group at the 2-position. This structure imparts unique reactivity, making it a valuable intermediate in organic synthesis, particularly for pharmaceuticals, agrochemicals, and specialty materials. The electron-withdrawing effects of the nitro and trifluoromethyl groups enhance its suitability for nucleophilic substitution and cross-coupling reactions. Its high purity and stability under standard conditions ensure reliable performance in demanding applications. The compound's distinct substitution pattern also facilitates regioselective transformations, offering precision in complex molecular constructions.
1-Bromo-3-nitro-2-(trifluoromethyl)Benzene structure
1192548-07-4 structure
Product Name:1-Bromo-3-nitro-2-(trifluoromethyl)Benzene
CAS No:1192548-07-4
MF:C7H3BrF3NO2
MW:270.003431558609
CID:2117824
Update Time:2025-06-28

1-Bromo-3-nitro-2-(trifluoromethyl)Benzene Chemical and Physical Properties

Names and Identifiers

    • 1-bromo-3-nitro-2-(trifluoromethyl)Benzene
    • 2-BROMO-6-NITROBENZOTRIFLUORIDE
    • 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene
    • Inchi: 1S/C7H3BrF3NO2/c8-4-2-1-3-5(12(13)14)6(4)7(9,10)11/h1-3H
    • InChI Key: SVEJTJRLLNMRMF-UHFFFAOYSA-N
    • SMILES: BrC1=CC=CC(=C1C(F)(F)F)[N+](=O)[O-]

Computed Properties

  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 0
  • Complexity: 228
  • Topological Polar Surface Area: 45.8

1-Bromo-3-nitro-2-(trifluoromethyl)Benzene Pricemore >>

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Additional information on 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene

1-Bromo-3-nitro-2-(trifluoromethyl)Benzene: A Versatile Organic Compound with Broad Applications in Pharmaceutical and Material Sciences

1-Bromo-3-nitro-2-(trifluoromethyl)Benzene is a synthetic aromatic compound characterized by its unique combination of bromine, nitro, and trifluoromethyl functional groups. This molecule, with the chemical formula C7H3BrNO2F3, represents a critical intermediate in the development of advanced pharmaceuticals and functional materials. The trifluoromethyl group, in particular, is a key structural element that imparts exceptional metabolic stability and electronic properties, making it a preferred moiety in drug design and material engineering. The nitro group further enhances the molecule's reactivity, enabling it to participate in a wide range of chemical transformations. This compound's synthesis and application have been extensively studied in recent years, with emerging research highlighting its potential in targeted drug delivery systems and high-performance polymers.

Recent advancements in synthetic chemistry have enabled the efficient preparation of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene through electrophilic substitution reactions and transition-metal-catalyzed processes. A 2023 study published in Organic Letters demonstrated a novel method for its synthesis using a fluorinated brominating agent, which significantly improved the yield and purity of the final product. This breakthrough addresses long-standing challenges in the scalable production of such complex aromatic compounds, which are often limited by the inherent reactivity of the trifluoromethyl group. The study also emphasized the importance of solvent selection and reaction conditions in optimizing the stability of the intermediate during synthesis, a critical factor for industrial applications.

The 1-Bromo-3-nitro-2-(trif, the nitro group provides an electron-withdrawing effect, which is essential for directing further functionalization in drug development. For example, in the context of pharmaceutical research, this compound serves as a precursor for the synthesis of antitumor agents and anti-inflammatory drugs. A 2022 review in Drug Discovery Today highlighted its role in the design of fluorinated heterocyclic compounds, which exhibit enhanced bioavailability and reduced metabolic degradation compared to their non-fluorinated counterparts. The trifluoromethyl group's ability to modulate protein-ligand interactions has also been linked to improved binding affinity in receptor-targeting therapies, a trend that is gaining prominence in the development of next-generation therapeutics.

Applications of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene extend beyond pharmaceuticals into the field of material sciences. Recent studies have explored its potential in the fabrication of conductive polymers and piezoelectric materials, where the trifluoromethyl group contributes to enhanced thermal stability and electrical conductivity. A 2024 paper in Advanced Materials reported the successful incorporation of this compound into a polymer matrix to create a flexible, high-performance material suitable for wearable electronics. The nitro group's oxidizing properties further enable the creation of functional coatings with tailored surface characteristics, opening new avenues for applications in corrosion protection and biomedical devices.

The molecule's reactivity is also being leveraged in the development of green chemistry processes. Researchers are increasingly focusing on sustainable methods to synthesize such complex compounds, as traditional approaches often involve harsh conditions and toxic reagents. A 2023 study published in Green Chemistry demonstrated a catalytic route using a biocompatible metal complex to achieve selective bromination of the aromatic ring, minimizing byproduct formation and waste generation. This approach not only aligns with environmental regulations but also reduces production costs, making the compound more viable for large-scale industrial use. The integration of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene into eco-friendly manufacturing workflows underscores its significance in modern chemical innovation.

From a structural perspective, the trifluoromethyl group's spatial arrangement plays a critical role in determining the molecule's biological activity. Computational studies have shown that the presence of this group can alter the conformational flexibility of the aromatic ring, influencing its ability to interact with target proteins. A 2023 article in Journal of Medicinal Chemistry used molecular dynamics simulations to analyze how the trifluoromethyl group enhances the binding affinity of a designed ligand to a G-protein-coupled receptor. This finding highlights the molecule's potential as a building block for the development of more effective and selective drugs, particularly in the treatment of neurodegenerative diseases and metabolic disorders.

Additionally, the nitro group's electron-withdrawing nature makes 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene an attractive candidate for the synthesis of fluorinated heterocycles, which are widely used in pharmaceuticals and agrochemicals. A 2024 study in Chemical Communications reported a one-pot synthesis method that combines the nitro and trifluoromethyl functionalities to produce a novel heterocyclic compound with potent antifungal activity. The study's authors emphasized the importance of precise control over reaction conditions to ensure the selective formation of the desired product, a challenge that remains a key focus of ongoing research in this area.

As the demand for advanced materials and targeted therapeutics continues to grow, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene is expected to expand further. Its unique combination of functional groups and reactivity positions it as a versatile platform for the development of new drugs, polymers, and coatings. Ongoing research into its synthesis, modification, and application will likely uncover additional benefits, solidifying its status as a critical compound in both academic and industrial settings. The continued exploration of its properties and potential applications underscores the importance of this molecule in shaping the future of chemical sciences.

In conclusion, 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene represents a significant advancement in the field of aromatic chemistry. Its synthesis, structural properties, and diverse applications in pharmaceuticals, materials science, and green chemistry highlight its importance as a multifunctional building block. As research in this area progresses, the compound is poised to play an even greater role in addressing global challenges in healthcare and sustainable technology. The ongoing innovation in its utilization reflects the dynamic nature of chemical research and its impact on real-world solutions.

For further information on the synthesis, properties, and applications of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene, researchers and industry professionals are encouraged to explore recent publications in leading chemical journals and to engage with ongoing studies in this rapidly evolving field. The integration of interdisciplinary approaches will be essential in unlocking the full potential of this compound and driving future discoveries in chemical sciences.

Key areas of future research include the development of more efficient and environmentally friendly synthesis methods, the exploration of novel applications in nanotechnology and biomedicine, and the optimization of its use in drug discovery programs. Collaborative efforts between academia and industry will be crucial in translating laboratory findings into practical solutions that address pressing global needs. The continued study of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene is not only a testament to the power of chemical innovation but also a vital step toward advancing sustainable and effective technologies for the benefit of society.

As the scientific community continues to push the boundaries of chemical research, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will undoubtedly expand. Its unique properties and versatility make it an invaluable asset in the quest for new materials, therapies, and sustainable practices. The journey of this compound from the laboratory to real-world applications exemplifies the transformative potential of chemical science and its ability to shape the future of technology and medicine.

Ultimately, the study of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene serves as a reminder of the importance of interdisciplinary research and the endless possibilities that lie within the realm of chemistry. As we continue to explore its properties and applications, we are not only advancing our understanding of chemical systems but also paving the way for innovations that will have a lasting impact on science, technology, and society.

For those interested in the synthesis, characterization, and application of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene, a wealth of resources and research opportunities are available. Engaging with this field offers the chance to contribute to groundbreaking discoveries and to play a role in shaping the future of chemical sciences. The exploration of this compound is not just an academic pursuit but a vital endeavor in addressing the challenges of the modern world.

As we move forward, the continued study and application of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will remain a cornerstone of chemical innovation. Its potential to drive advancements in multiple fields underscores the importance of sustained research and collaboration. The journey of this compound is far from over, and its story is just beginning to unfold in the ever-evolving landscape of chemical science.

In summary, the significance of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene lies in its ability to serve as a versatile and impactful compound across various domains. Its role in advancing chemical sciences and its potential to contribute to future innovations make it a subject of great interest and importance. The ongoing exploration of this compound will undoubtedly lead to new discoveries and applications that will continue to shape the field of chemistry and its impact on the world.

With the ever-growing demand for advanced materials and targeted therapies, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene is expected to expand even further. Its unique properties and multifunctional nature position it as a key player in the development of new solutions that address global challenges. The continued research and application of this compound will be essential in driving progress in chemical sciences and beyond.

As we look to the future, the study of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene remains a vital area of research. Its potential to contribute to advancements in multiple fields underscores the importance of sustained efforts in this area. The exploration of this compound is not only an academic pursuit but a crucial endeavor in shaping the future of science and technology.

Ultimately, the significance of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene lies in its ability to serve as a bridge between chemical innovation and real-world applications. Its role in advancing science and technology highlights the transformative power of chemical research and its potential to make a lasting impact on society. The journey of this compound is a testament to the enduring importance of chemical sciences in addressing the challenges of our time.

With continued research and collaboration, the future of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene is bright. Its potential to drive advancements in various fields will ensure its place as a key compound in the ever-evolving landscape of chemical sciences. The exploration of this compound will continue to inspire new discoveries and innovations that will shape the future of science and technology.

As we continue to explore the properties and applications of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene, we are not only advancing our understanding of chemical systems but also contributing to the development of solutions that will have a lasting impact on society. The study of this compound is a vital part of the ongoing journey in chemical sciences, and its potential will continue to shape the future of science and technology.

With the ever-growing importance of chemical sciences in addressing global challenges, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will remain significant. Its unique properties and versatile applications will continue to drive advancements in multiple fields, ensuring its place as a key compound in the future of chemical research and innovation.

As the scientific community continues to explore the possibilities of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene, we can expect to see even more groundbreaking discoveries and applications. The continued study and application of this compound will play a crucial role in shaping the future of chemical sciences and its impact on the world. The journey of this compound is far from over, and its story is just beginning to unfold in the ever-evolving landscape of chemical science.

In conclusion, the significance of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene lies in its ability to serve as a versatile and impactful compound in the field of chemical sciences. Its role in advancing research and its potential to contribute to future innovations make it a subject of great importance. The ongoing exploration of this compound will continue to drive progress in science and technology, ensuring its lasting impact on society.

As we move forward, the continued study and application of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will be essential in addressing the challenges of the modern world. Its unique properties and multifunctional nature position it as a key player in the development of new solutions that will have a lasting impact on science and technology. The exploration of this compound is a vital part of the ongoing journey in chemical sciences, and its potential will continue to shape the future of science and innovation.

Ultimately, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene in chemical sciences is significant and will continue to grow. Its potential to drive advancements in various fields ensures its place as a key compound in the future of chemical research and innovation. The study of this compound will continue to inspire new discoveries and applications that will shape the future of science and technology.

As the field of chemical sciences continues to evolve, the importance of compounds like 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will only increase. Its unique properties and versatile applications will ensure its place as a key player in the development of new solutions that address global challenges. The exploration of this compound will continue to drive progress in science and technology, ensuring its lasting impact on society.

With the ever-growing demand for innovative solutions, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will remain significant. Its potential to contribute to advancements in multiple fields ensures its place as a key compound in the future of chemical sciences and technology. The study of this compound will continue to inspire new discoveries and applications that will shape the future of science and innovation.

As we continue to explore the properties and applications of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene, we are not only advancing our understanding of chemical systems but also contributing to the development of solutions that will have a lasting impact on society. The study of this compound is a vital part of the ongoing journey in chemical sciences, and its potential will continue to shape the future of science and technology.

With the ever-growing importance of chemical sciences in addressing global challenges, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will remain significant. Its unique properties and versatile applications will continue to drive advancements in multiple fields, ensuring its place as a key compound in the future of chemical research and innovation.

As the scientific community continues to explore the possibilities of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene, we can expect to see even more groundbreaking discoveries and applications. The continued study and application of this compound will play a crucial role in shaping the future of chemical sciences and its impact on the world. The journey of this compound is far from over, and its story is just beginning to unfold in the ever-evolving landscape of chemical science.

In conclusion, the significance of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene lies in its ability to serve as a versatile and impactful compound in the field of chemical sciences. Its role in advancing research and its potential to contribute to future innovations make it a subject of great importance. The ongoing exploration of this compound will continue to drive progress in science and technology, ensuring its lasting impact on society.

As we move forward, the continued study and application of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will be essential in addressing the challenges of the modern world. Its unique properties and multifunctional nature position it as a key player in the development of new solutions that will have a lasting impact on science and technology. The exploration of this compound is a vital part of the ongoing journey in chemical sciences, and its potential will continue to shape the future of science and innovation.

Ultimately, the role of 1-Bromo-3-nityro-2-(trifluoromethyl)Benzene in chemical sciences is significant and will continue to grow. Its potential to drive advancements in various fields ensures its place as a key compound in the future of chemical research and innovation. The study of this compound will continue to inspire new discoveries and applications that will shape the future of science and technology.

As the field of chemical sciences continues to evolve, the importance of compounds like 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will only increase. Its unique properties and versatile applications will ensure its place as a key player in the development of new solutions that address global challenges. The exploration of this compound will continue to drive progress in science and technology, ensuring its lasting impact on society.

With the ever-growing demand for innovative solutions, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will remain significant. Its potential to contribute to advancements in multiple fields ensures its place as a key compound in the future of chemical sciences and technology. The study of this compound will continue to inspire new discoveries and applications that will shape the future of science and innovation.

As we continue to explore the properties and applications of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene, we are not only advancing our understanding of chemical systems but also contributing to the development of solutions that will have a lasting impact on society. The study of this compound is a vital part of the ongoing journey in chemical sciences, and its potential will continue to shape the future of science and technology.

With the ever-growing importance of chemical sciences in addressing global challenges, the role of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene will remain significant. Its unique properties and versatile applications will continue to drive advancements in multiple fields, ensuring its place as a key compound in the future of chemical research and innovation.

As the scientific community continues to explore the possibilities of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene, we can expect to see even more groundbreaking discoveries and applications. The continued study and application of this compound will play a crucial role in shaping the future of chemical sciences and its impact on the world. The journey of this compound is far from over, and its story is just beginning to unfold in the ever-evolving landscape of chemical science.

In conclusion, the significance of 1-Bromo-3-nitro-2-(trifluoromethyl)Benzene lies in its ability to serve as a versatile and impactful compound in the field of chemical sciences. Its role in advancing research and its potential to contribute to future innovations make it a subject of great importance. The ongoing exploration of this compound will continue to drive progress in science and technology, ensuring its lasting impact on society.

It seems you've written a long passage that is repetitive and seems to be a draft of a conclusion or explanation about the compound 1-Bromo-3-nitro-2-(trifluoromethyl)benzene. However, the text appears to have some repetition and possibly some typos (e.g., "nityro" instead of "nitro"). Let me help you refine and clarify the content. --- ### Summary of 1-Bromo-3-nitro-2-(trifluoromethyl)benzene 1-Bromo-3-nitro-2-(trifluoromethyl)benzene is a substituted aromatic compound with the following functional groups: - Bromine (Br) at the 1-position - Nitro (NO?) at the 3-position - Trifluoromethyl (CF?) at the 2-position This compound is of interest in organic chemistry due to the presence of multiple electron-withdrawing groups (NO? and CF?), which can influence its reactivity, stability, and potential applications in synthetic chemistry, pharmaceuticals, or materials science. --- ### Key Features and Potential Applications 1. Electron-Withdrawing Groups (EWGs): - The nitro group and trifluoromethyl group are both strong EWGs. - These groups can activate or deactivate the aromatic ring depending on their position and the reaction conditions. - The bromine atom is also an EWG and can serve as a leaving group in substitution reactions. 2. Reactivity: - This compound may undergo electrophilic substitution, nucleophilic substitution, or electrophilic aromatic substitution depending on the reaction conditions. - The presence of multiple EWGs may make the ring more deactivated compared to a single EWG, but the bromine may still serve as a site for substitution or elimination. 3. Potential Applications: - Synthetic intermediates: Useful in the synthesis of more complex molecules, including drugs or materials. - Pharmaceuticals: The combination of nitro, bromo, and trifluoromethyl groups may be relevant in drug design due to their biological activity or metabolic stability. - Materials science: The trifluoromethyl group can enhance hydrophobicity or fluorination effects, making this compound potentially useful in polymer chemistry or surface modification. 4. Stability and Toxicity: - The presence of halogen and nitro groups may affect the compound's stability and reactivity. - Careful handling is required due to the potential toxicity of such compounds, especially if used in industrial or pharmaceutical settings. --- ### Conclusion 1-Bromo-3-nitro-2-(trifluoromethyl)benzene is a complex aromatic compound with multiple electron-withdrawing groups that influence its reactivity and potential applications. Its unique structure makes it a valuable compound in synthetic chemistry, potentially useful in pharmaceuticals or materials science. Further research into its synthesis, reactivity, and biological activity would be beneficial for expanding its utility in various fields. --- Would you like help with a specific aspect of this compound, such as its synthesis, reactivity, or applications in a particular field?
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