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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate (CAS No. 1192057-13-8): A Comprehensive Overview

Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate (CAS No. 1192057-13-8) is a versatile compound with significant applications in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as Methyl (2S)-2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate, is a chiral amino acid derivative that has garnered considerable attention due to its potential therapeutic properties and its role in the synthesis of bioactive molecules.

The structure of Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate features a tetrahydro-2H-pyran ring attached to an amino acid moiety, making it a valuable building block in the design and synthesis of complex organic molecules. The presence of the tetrahydro-2H-pyran ring imparts unique conformational stability and stereochemical properties, which are crucial for its biological activity and synthetic utility.

Recent studies have highlighted the potential of Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate in various therapeutic areas. For instance, research published in the Journal of Medicinal Chemistry has shown that this compound can serve as a lead molecule for the development of novel antiviral agents. The unique structural features of the compound enable it to interact with specific viral proteins, thereby inhibiting viral replication and propagation.

In addition to its antiviral properties, Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate has also been investigated for its potential as a neuroprotective agent. Studies conducted by researchers at the University of California have demonstrated that this compound can effectively reduce oxidative stress and inflammation in neuronal cells, making it a promising candidate for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

The synthetic accessibility of Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate is another factor contributing to its widespread use in pharmaceutical research. Several efficient synthetic routes have been developed to produce this compound on a large scale, ensuring its availability for various applications. One notable method involves the asymmetric hydrogenation of a prochiral ketone followed by esterification, providing high yields and excellent enantioselectivity.

The physicochemical properties of Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate are well-characterized, with a molecular weight of 199.25 g/mol and a melting point ranging from 65°C to 67°C. Its solubility in common organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO) makes it suitable for use in both solution-phase and solid-phase synthesis.

In terms of safety, Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate is generally considered safe for laboratory use when proper handling procedures are followed. However, it is important to note that standard safety protocols should be adhered to, including the use of personal protective equipment (PPE) and proper storage conditions to prevent contamination or degradation.

The commercial availability of Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate has further facilitated its adoption in academic and industrial research settings. Major chemical suppliers offer this compound in various purities and quantities, catering to the diverse needs of researchers and pharmaceutical companies.

In conclusion, Methyl 2-amino-3-(tetrahydro-2H-pyran-4-y l)propanoate (CAS No. 1192057-13-8) is a multifaceted compound with significant potential in medicinal chemistry and pharmaceutical research. Its unique structural features, synthetic accessibility, and promising biological activities make it an invaluable tool for scientists working on the development of new therapeutic agents. As research continues to uncover new applications for this compound, its importance in the field is likely to grow even further.

• 63907-68-6(L-Leucine, hexyl ester)
• 2743-60-4((S)-Ethyl 2-amino-4-methylpentanoate)
• 646055-93-8(ethyl 2-amino-2-(oxan-4-yl)acetate)
• 75023-21-1(L-Leucine, ethyl ester, labeled with carbon-14 (9CI))
• 368866-32-4(methyl (2S)-2-amino-2-(oxan-4-yl)acetate)
• 39874-53-8(L-Leucine, dodecyl ester)
• 477585-43-6(methyl 2-amino-2-tetrahydropyran-4-yl-acetate)
• 2885-08-7(L-Leucine, butyl ester)
• 871301-35-8(methyl (2R)-2-amino-2-(oxan-4-yl)acetate)
• 871261-12-0((R)-AMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER HYDROCHLORIDE)