• 1. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 5. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768

Research Briefing on Methyl 6-aminopyrazine-2-carboxylate (CAS: 118853-60-4) in Chemical Biology and Pharmaceutical Applications

Methyl 6-aminopyrazine-2-carboxylate (CAS: 118853-60-4) is a heterocyclic compound that has garnered significant attention in recent years due to its versatile applications in medicinal chemistry and drug discovery. This compound serves as a key intermediate in the synthesis of various biologically active molecules, particularly those targeting kinase inhibition and antimicrobial activity. Recent studies have explored its potential in the development of novel therapeutics, leveraging its unique chemical properties and reactivity.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers investigated the role of Methyl 6-aminopyrazine-2-carboxylate as a precursor in the synthesis of pyrazine-based kinase inhibitors. The study highlighted its efficacy in forming stable complexes with ATP-binding sites of target kinases, demonstrating promising inhibitory activity against cancer-related kinases such as EGFR and BRAF. The compound's structural flexibility allows for further derivatization, enabling the optimization of pharmacokinetic properties.

Another notable application of Methyl 6-aminopyrazine-2-carboxylate is in antimicrobial drug development. A 2022 study in Bioorganic & Medicinal Chemistry Letters reported its use as a scaffold for designing novel antibiotics targeting multidrug-resistant bacterial strains. The study revealed that derivatives of this compound exhibited potent activity against Gram-positive bacteria, including MRSA, by disrupting cell wall synthesis. The findings underscore its potential as a lead compound for addressing antibiotic resistance.

Beyond its therapeutic applications, Methyl 6-aminopyrazine-2-carboxylate has also been employed in chemical biology research. A recent preprint (2024) on ChemRxiv described its use as a fluorescent probe for detecting reactive oxygen species (ROS) in cellular environments. The probe's high selectivity and sensitivity make it a valuable tool for studying oxidative stress-related diseases, such as neurodegenerative disorders and cancer.

In conclusion, Methyl 6-aminopyrazine-2-carboxylate (CAS: 118853-60-4) continues to be a compound of interest in the pharmaceutical and chemical biology fields. Its multifunctional role as a synthetic intermediate, therapeutic agent, and research tool highlights its broad utility. Future research is expected to further explore its applications, particularly in personalized medicine and targeted drug delivery systems.

• 16298-03-6(methyl 3-aminopyrazine-2-carboxylate)
• 710322-34-2(2-Pyrazinecarboxylicacid, 5-amino-, 1,1-dimethylethyl ester)
• 61442-38-4(6-Aminopyrazine-2-carboxylic acid)
• 13924-94-2(Methyl 5-aminopyrazine-2-carboxylate)
• 6294-72-0(Methyl 3-amino-5,6-dimethylpyrazine-2-carboxylate)
• 54013-06-8(Ethyl 5-Aminopyrazine-2-carboxylate)
• 40155-43-9(5-Aminopyrazine-2-carboxylic acid)
• 61442-39-5(6-amino-2-Pyrazinecarboxylic acid ethyl ester)
• 36526-32-6(Ethyl 3-aminopyrazine-2-carboxylate)
• 64882-36-6(2-Pyrazinecarboxylicacid, 3-amino-6-methyl-, ethyl ester)