• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 3. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 5. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625

Comprehensive Overview of rac-tert-butyl (1s,4s)-4-aminocyclohexane-1-carboxylate hydrochloride, cis (CAS No. 118786-13-3)

The compound rac-tert-butyl (1s,4s)-4-aminocyclohexane-1-carboxylate hydrochloride, cis (CAS No. 118786-13-3) is a chiral intermediate widely used in pharmaceutical synthesis and organic chemistry research. Its unique structural features, including the tert-butyl ester and cis-aminocyclohexane moieties, make it a valuable building block for drug discovery and development. With the growing demand for enantiomerically pure compounds in the pharmaceutical industry, this intermediate has gained significant attention for its role in synthesizing bioactive molecules.

One of the key advantages of rac-tert-butyl (1s,4s)-4-aminocyclohexane-1-carboxylate hydrochloride, cis is its stability under various reaction conditions, which makes it suitable for multi-step synthetic routes. Researchers often utilize this compound in the preparation of chiral amines and cyclohexane derivatives, which are essential scaffolds in many therapeutic agents. Recent studies have highlighted its potential in developing CNS-targeting drugs and GPCR modulators, aligning with current trends in neuroscience and precision medicine.

The synthesis of rac-tert-butyl (1s,4s)-4-aminocyclohexane-1-carboxylate hydrochloride, cis typically involves the resolution of racemic mixtures or asymmetric hydrogenation techniques. Advanced purification methods, such as chiral chromatography and recrystallization, ensure high enantiomeric purity, meeting the stringent requirements of pharmaceutical applications. The hydrochloride salt form enhances its solubility and handling properties, making it a preferred choice for laboratory and industrial use.

In the context of green chemistry and sustainable synthesis, researchers are exploring eco-friendly approaches to produce rac-tert-butyl (1s,4s)-4-aminocyclohexane-1-carboxylate hydrochloride, cis. Catalytic methods using biocatalysts and metal-free conditions are gaining traction, addressing the growing emphasis on reducing environmental impact. These innovations align with the pharmaceutical industry's shift toward greener processes and circular economy principles.

From a market perspective, the demand for rac-tert-butyl (1s,4s)-4-aminocyclohexane-1-carboxylate hydrochloride, cis is driven by its applications in small-molecule drug development and peptide mimetics. The rise of targeted therapies and personalized medicine has further amplified its importance, as researchers seek versatile intermediates for novel drug candidates. Analytical techniques like HPLC and NMR are routinely employed to characterize this compound, ensuring compliance with regulatory standards.

For researchers and manufacturers, sourcing high-quality rac-tert-butyl (1s,4s)-4-aminocyclohexane-1-carboxylate hydrochloride, cis is critical. Reputable suppliers provide detailed certificates of analysis (CoA) and technical data sheets, facilitating seamless integration into synthetic workflows. Storage recommendations typically include cool, dry conditions to maintain stability, with precautions to avoid moisture exposure.

Looking ahead, the versatility of rac-tert-butyl (1s,4s)-4-aminocyclohexane-1-carboxylate hydrochloride, cis positions it as a key player in advancing medicinal chemistry and drug discovery. Its compatibility with diverse synthetic strategies and potential for structural modifications make it a valuable asset for tackling unmet medical needs. As the pharmaceutical landscape evolves, this compound is poised to remain at the forefront of innovation.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)