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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines Pyridinylpiperazines

1-Methyl-4-(3-methylpyridin-2-yl)piperazine (CAS 1187386-43-1): A Comprehensive Overview

In the realm of heterocyclic compounds, 1-Methyl-4-(3-methylpyridin-2-yl)piperazine (CAS 1187386-43-1) stands out as a molecule of significant interest due to its unique structural features and potential applications. This compound, which combines a piperazine ring with a methylpyridine moiety, has garnered attention in various scientific and industrial fields. Its molecular formula, C₁₁H_{17N3, and molecular weight of 191.27 g/mol, make it a versatile building block in organic synthesis and medicinal chemistry.}

The physicochemical properties of 1-Methyl-4-(3-methylpyridin-2-yl)piperazine contribute to its utility in research and development. It typically appears as a light yellow to brown solid with a melting point range that makes it suitable for various laboratory conditions. Its solubility in common organic solvents like dimethyl sulfoxide (DMSO) and methanol enhances its applicability in chemical reactions. Researchers often explore its hydrogen bonding capacity and lipophilicity, which are crucial factors in drug design and material science applications.

Recent trends in pharmaceutical research have highlighted the importance of piperazine derivatives like 1-Methyl-4-(3-methylpyridin-2-yl)piperazine. These compounds frequently appear in studies targeting central nervous system (CNS) disorders, with particular interest in their potential as dopamine receptor modulators. The compound's structural similarity to known bioactive molecules has led to investigations into its possible neuropharmacological activities, though these applications remain in the research phase.

In the field of material science, 1-Methyl-4-(3-methylpyridin-2-yl)piperazine has shown promise as a precursor for coordination polymers and metal-organic frameworks (MOFs). Its ability to act as a bridging ligand makes it valuable in creating novel materials with potential applications in gas storage and catalysis. The compound's thermal stability and coordination chemistry are currently being explored in various academic and industrial laboratories worldwide.

The synthetic chemistry community has developed several efficient routes to produce 1-Methyl-4-(3-methylpyridin-2-yl)piperazine with high purity. Common methods involve the nucleophilic substitution of appropriately substituted pyridine derivatives with N-methylpiperazine. Recent advances in green chemistry have led to the development of more sustainable synthetic protocols, reducing the environmental impact of its production while maintaining high yields and purity.

Quality control of 1-Methyl-4-(3-methylpyridin-2-yl)piperazine typically involves advanced analytical techniques. High-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy are standard methods for verifying the compound's identity and purity. These analytical procedures ensure that the material meets the stringent requirements of research and industrial applications, particularly in pharmaceutical development where purity is paramount.

The commercial availability of 1-Methyl-4-(3-methylpyridin-2-yl)piperazine has increased in recent years, reflecting growing demand from the scientific community. Suppliers typically offer the compound in various quantities, from milligram-scale for research purposes to kilogram quantities for industrial applications. Proper storage conditions, typically in a cool, dry environment protected from light, help maintain the compound's stability over extended periods.

Safety considerations for handling 1-Methyl-4-(3-methylpyridin-2-yl)piperazine follow standard laboratory protocols. While not classified as highly hazardous, appropriate personal protective equipment including laboratory gloves and safety glasses is recommended when working with this compound. Material safety data sheets (MSDS) provide detailed information about handling, storage, and disposal procedures to ensure safe laboratory practices.

Future research directions for 1-Methyl-4-(3-methylpyridin-2-yl)piperazine may explore its potential in emerging fields such as bioorthogonal chemistry and click chemistry applications. The compound's structural features make it a candidate for developing new fluorescent probes or bioconjugation reagents. Additionally, its potential as a scaffold for drug discovery continues to attract interest from medicinal chemists seeking novel therapeutic agents.

In conclusion, 1-Methyl-4-(3-methylpyridin-2-yl)piperazine (CAS 1187386-43-1) represents an important compound in contemporary chemical research. Its diverse potential applications span from pharmaceutical development to advanced materials, reflecting the versatility of piperazine-based compounds in modern science. As research progresses, new uses for this interesting molecule will likely continue to emerge, solidifying its position as a valuable tool in chemical innovation.

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