• 1. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 2. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 3. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
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• 4. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
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• 5. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

2-Chloro-4-(Trifluoromethoxy)Aniline Hydrochloride: A Comprehensive Overview

2-Chloro-4-(Trifluoromethoxy)Aniline Hydrochloride, also known by its CAS number 1187386-31-7, is a significant compound in the field of organic chemistry, particularly in the synthesis of heterocyclic compounds and pharmaceutical intermediates. This compound has garnered attention due to its unique structural features and versatile applications in drug discovery and materials science.

The molecular structure of 2-Chloro-4-(Trifluoromethoxy)Aniline Hydrochloride comprises a chlorinated aromatic ring with a trifluoromethoxy substituent, which imparts unique electronic properties. The presence of the trifluoromethoxy group (-OCF?) is notable for its strong electron-withdrawing effect, making this compound highly reactive in various nucleophilic aromatic substitution reactions. This feature has been extensively exploited in the synthesis of bioactive molecules, including antiviral agents and anticancer drugs.

Recent studies have highlighted the role of 2-Chloro-4-(Trifluoromethoxy)Aniline Hydrochloride in the development of novel materials with tailored electronic properties. For instance, researchers have utilized this compound as a precursor for the synthesis of advanced polymers and organic semiconductors, which exhibit improved charge transport characteristics. These findings underscore its potential in advancing next-generation electronic devices.

In terms of synthesis, 2-Chloro-4-(Trifluoromethoxy)Aniline Hydrochloride can be prepared via a variety of methods, including Friedel-Crafts acylation and subsequent functionalization. The hydrochloride salt form is particularly advantageous for enhancing solubility and stability during reaction processes, making it a preferred choice in large-scale manufacturing.

The applications of this compound extend beyond traditional pharmaceuticals into areas such as agrochemicals and specialty chemicals. Its ability to act as an intermediate in the synthesis of herbicides and fungicides has made it a valuable asset in agricultural chemistry. Moreover, recent advancements in green chemistry have led to the exploration of more sustainable synthetic routes for this compound, aligning with global efforts to reduce environmental impact.

In conclusion, 2-Chloro-4-(Trifluoromethoxy)Aniline Hydrochloride, with its distinctive chemical properties and wide-ranging applications, continues to be a focal point in contemporary chemical research. As new discoveries emerge, this compound is poised to play an even greater role in shaping the future of drug development and materials innovation.

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• 6695-61-0(2-Chloro-4-(trifluoromethoxy)aniline)
• 151276-14-1(Benzenamine,2-chloro-3-(trifluoromethoxy)-)
• 151276-13-0(3-Chloro-5-(trifluoromethoxy)aniline)
• 1598-42-1(2,4-Dichloro-5-(trifluoromethoxy)aniline)
• 1261673-70-4(2-chloro-6-(trifluoromethoxy)aniline)
• 69695-61-0(2-Chloro-4-(trifluoromethoxy)aniline)
• 175205-77-3(4-Chloro-2-(trifluoromethoxy)aniline)
• 1261849-95-9(3-chloro-5-(difluoromethoxy)benzenamine)
• 331-26-0(2-Chloro-5-(trifluoromethoxy)aniline)