• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
• 3. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 4. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

Introduction to 5-Methyl-2-(4-nitrobenzoyl)pyridine (CAS No: 1187164-50-6)

5-Methyl-2-(4-nitrobenzoyl)pyridine, with the chemical formula C₁₃H₁₀N₂O₃, is a significant compound in the realm of pharmaceutical and chemical research. This compound, identified by its CAS number 1187164-50-6, has garnered attention due to its versatile applications in synthetic chemistry and potential roles in drug development. The structural integrity of this molecule, featuring a pyridine core substituted with a methyl group and a 4-nitrobenzoyl moiety, makes it a valuable intermediate in various chemical syntheses.

The utility of 5-Methyl-2-(4-nitrobenzoyl)pyridine stems from its unique reactivity, which allows it to participate in multiple chemical transformations. The presence of the nitro group and the benzoyl moiety enhances its compatibility with a range of functional groups, making it a pivotal building block in organic synthesis. Researchers have leveraged these properties to develop novel methodologies for constructing complex molecular architectures.

In recent years, the compound has been explored for its potential applications in medicinal chemistry. The pyridine ring is a common pharmacophore in many bioactive molecules, and modifications at the 5-position can significantly influence biological activity. Studies have shown that derivatives of this compound exhibit promising pharmacological properties, including antimicrobial and anti-inflammatory effects. These findings have spurred further investigation into the synthesis of analogs that may enhance therapeutic efficacy.

The synthesis of 5-Methyl-2-(4-nitrobenzoyl)pyridine involves multi-step organic reactions that highlight the compound's synthetic versatility. The process typically begins with the nitration of benzoyl chloride, followed by condensation with methylamine and subsequent functionalization at the pyridine ring. Advanced techniques such as palladium-catalyzed cross-coupling reactions have also been employed to optimize yield and purity. These synthetic strategies underscore the importance of this compound as a key intermediate in industrial and academic research.

Recent advancements in computational chemistry have further illuminated the potential of 5-Methyl-2-(4-nitrobenzoyl)pyridine. Molecular modeling studies have provided insights into its interactions with biological targets, aiding in the design of more effective drug candidates. The nitro group, in particular, has been found to modulate binding affinity through hydrogen bonding and electrostatic interactions. Such findings are crucial for rational drug design and highlight the compound's significance in modern pharmaceutical research.

The compound's role extends beyond synthetic intermediates; it also serves as a substrate for enzyme-mediated transformations. Enzymes such as cytochrome P450 oxidases can metabolize this molecule, providing valuable insights into drug metabolism and potential side effects. Understanding these metabolic pathways is essential for developing safer and more effective therapeutic agents. The integration of enzymology with synthetic chemistry has opened new avenues for drug discovery.

In conclusion, 5-Methyl-2-(4-nitrobenzoyl)pyridine (CAS No: 1187164-50-6) is a multifaceted compound with significant implications in pharmaceutical research. Its structural features enable diverse chemical transformations, making it a valuable tool for synthetic chemists. Moreover, its potential biological activities and metabolic interactions position it as a promising candidate for future drug development. As research continues to uncover new applications, this compound will undoubtedly remain at the forefront of chemical innovation.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)