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Comprehensive Guide to 6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride (CAS No. 1185311-52-7)

6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride (CAS No. 1185311-52-7) is a specialized chemical compound widely used in pharmaceutical research and development. This compound belongs to the pyrimidine class, known for its significance in drug discovery and medicinal chemistry. Researchers and industry professionals often seek detailed information about its properties, applications, and synthesis methods, making it a popular topic in scientific literature and online searches.

The molecular structure of 6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride includes a pyrimidine core, a piperidinylmethyl group, and a chloro substituent, contributing to its unique chemical behavior. Its hydrochloride salt form enhances solubility, making it suitable for various experimental and industrial applications. The compound’s CAS number, 1185311-52-7, is a critical identifier for procurement and regulatory compliance.

One of the key applications of 6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride is in the development of kinase inhibitors, a hot topic in cancer research. Kinase inhibitors are a major focus in precision medicine, and this compound’s structural features make it a valuable intermediate in synthesizing potential therapeutic agents. Recent trends in AI-driven drug discovery have also increased interest in such compounds, as they are often used in machine learning models to predict bioactive molecules.

In addition to its pharmaceutical applications, 6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride is studied for its potential role in neurodegenerative disease research. The piperidine moiety is a common pharmacophore in central nervous system (CNS) drugs, and modifications of this scaffold are frequently explored for treating conditions like Alzheimer’s and Parkinson’s diseases. This aligns with growing public interest in neurodegenerative treatments, as evidenced by frequent searches for "new Alzheimer’s drug targets" and "CNS drug development."

The synthesis of 6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride involves multi-step organic reactions, including nucleophilic substitution and salt formation. Researchers often optimize these processes to improve yield and purity, which are critical for reproducibility in drug development. Questions like "how to synthesize pyrimidine derivatives" or "best practices for hydrochloride salt formation" are common among chemists, reflecting the demand for practical guidance in this area.

From a commercial perspective, 6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride is supplied by several specialty chemical manufacturers. Its pricing and availability are influenced by factors such as raw material costs and demand from the pharmaceutical sector. Companies often search for "reliable suppliers of CAS 1185311-52-7" or "bulk purchase of pyrimidine derivatives," highlighting the need for transparent supply chain information.

Quality control is another critical aspect when working with 6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride. Analytical techniques like HPLC, NMR, and mass spectrometry are used to verify purity and structural integrity. Laboratories frequently inquire about "analytical methods for pyrimidine compounds" or "certificates of analysis for CAS 1185311-52-7," emphasizing the importance of standardized testing protocols.

In summary, 6-Chloro-N-(4-piperidinylmethyl)-4-pyrimidinamine hydrochloride (CAS No. 1185311-52-7) is a versatile compound with significant applications in drug discovery and medicinal chemistry. Its relevance to cutting-edge research areas like kinase inhibitors and neurodegenerative diseases ensures continued interest from the scientific community. By addressing common queries and industry trends, this guide provides a comprehensive resource for researchers, suppliers, and professionals seeking in-depth knowledge about this compound.

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