• 1. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 2. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 5. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064

Introduction to 1-Cycloheptylpiperidin-3-aminesulfate (CAS No: 1185303-68-7)

1-Cycloheptylpiperidin-3-aminesulfate, identified by its Chemical Abstracts Service (CAS) number 1185303-68-7, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the piperidine class of heterocyclic amines, characterized by a six-membered ring containing one nitrogen atom. The introduction of a cycloheptyl side chain and a sulfated amine group at the 3-position enhances its pharmacological profile, making it a valuable intermediate in the synthesis of bioactive molecules.

The structural motif of 1-Cycloheptylpiperidin-3-aminesulfate imparts unique physicochemical properties that are highly relevant for drug development. The sulfation at the amine group not only influences solubility and bioavailability but also modulates interactions with biological targets. This compound has been explored in various therapeutic contexts, particularly in the design of novel pharmacophores targeting neurological and cardiovascular disorders.

Recent advancements in computational chemistry and molecular modeling have highlighted the potential of 1-Cycloheptylpiperidin-3-aminesulfate as a scaffold for drug discovery. Its rigid piperidine core provides a stable framework for further derivatization, while the sulfated amine group offers opportunities for hydrogen bonding and ionic interactions with biological receptors. Studies have demonstrated its utility in developing ligands for G-protein coupled receptors (GPCRs) and ion channels, which are critical targets in modern medicine.

In the realm of medicinal chemistry, the synthesis of 1-Cycloheptylpiperidin-3-aminesulfate has been optimized through multi-step organic reactions, including nucleophilic substitution, cyclization, and sulfation protocols. These synthetic strategies ensure high yield and purity, which are essential for preclinical and clinical studies. The compound's stability under various storage conditions further enhances its feasibility for industrial-scale production.

One of the most compelling aspects of 1-Cycloheptylpiperidin-3-aminesulfate is its role in addressing unmet medical needs. Research groups have leveraged this scaffold to develop potential treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's. Preclinical data suggest that derivatives of this compound can modulate neurotransmitter release and inhibit pathological protein aggregation, offering promising avenues for therapeutic intervention.

The pharmacokinetic profile of 1-Cycloheptylpiperidin-3-aminesulfate has been thoroughly investigated to ensure optimal drug delivery. Studies indicate that sulfated piperidine derivatives exhibit favorable absorption, distribution, metabolism, and excretion (ADME) properties. This makes them suitable candidates for oral administration and systemic circulation, reducing the need for invasive delivery methods.

Moreover, the environmental impact of synthesizing 1-Cycloheptylpiperidin-3-aminesulfate has been considered in recent research efforts. Green chemistry principles have been applied to minimize waste generation and energy consumption during production. These sustainable practices align with global initiatives to promote eco-friendly pharmaceutical manufacturing.

The future prospects of 1-Cycloheptylpiperidin-3-aminesulfate extend beyond traditional pharmaceutical applications. Its structural versatility allows it to be incorporated into advanced materials such as polymers and nanoparticles for targeted drug delivery systems. Such innovations could enhance therapeutic efficacy while reducing side effects associated with conventional treatments.

In conclusion, 1-Cycloheptylpiperidin-3-aminesulfate represents a significant advancement in medicinal chemistry due to its unique structural features and broad therapeutic potential. Ongoing research continues to uncover new applications for this compound, reinforcing its importance in addressing complex diseases. As scientific understanding evolves, 1-Cycloheptylpiperidin-3-aminesulfate is poised to play an increasingly pivotal role in shaping the future of healthcare.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)