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  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 2. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Phenylpiperidines

Comprehensive Overview of 3-(3-Methylphenyl)piperidine hydrochloride (CAS No. 1184977-99-8)

3-(3-Methylphenyl)piperidine hydrochloride (CAS No. 1184977-99-8) is a specialized organic compound widely utilized in pharmaceutical research and fine chemical synthesis. This compound belongs to the piperidine derivative family, which is known for its versatile applications in drug discovery and development. The presence of a 3-methylphenyl group enhances its lipophilicity, making it a valuable intermediate for designing bioactive molecules targeting neurological and metabolic disorders.

In recent years, the demand for piperidine-based compounds has surged due to their role in developing novel therapeutics. Researchers frequently search for terms like "piperidine derivatives in drug design" or "3-methylphenyl piperidine applications", reflecting the growing interest in this chemical space. The hydrochloride salt form of this compound improves its solubility, facilitating its use in aqueous-based reactions and formulations.

The synthesis of 3-(3-Methylphenyl)piperidine hydrochloride involves multi-step organic reactions, including reductive amination and subsequent salt formation. Its molecular structure has been characterized using advanced techniques such as NMR spectroscopy and mass spectrometry, ensuring high purity (>98%) for research purposes. This level of purity is critical for reproducibility in pharmacological studies, a topic often queried in search engines as "high-purity piperidine compounds for research".

From a therapeutic perspective, this compound's structural features align with current trends in small molecule drug discovery. Its potential interactions with G-protein-coupled receptors (GPCRs) make it particularly interesting for researchers investigating neurotransmitter modulation—a hot topic in neuroscience circles. Online searches frequently include phrases like "GPCR-targeting piperidine compounds", indicating the compound's relevance in modern medicinal chemistry.

Stability studies of 3-(3-Methylphenyl)piperidine hydrochloride show excellent performance under standard laboratory conditions, with minimal degradation observed at room temperature when stored properly. This characteristic addresses common researcher concerns captured in search queries such as "stable piperidine derivatives storage". The compound's compatibility with various organic solvents expands its utility in diverse synthetic protocols.

In the context of green chemistry initiatives, recent modifications to the synthesis route of this compound have reduced environmental impact—a response to frequent searches about "sustainable synthesis of pharmaceutical intermediates". These improvements include catalyst optimization and waste minimization strategies, making the production process more aligned with contemporary green chemistry principles.

The analytical profile of 3-(3-Methylphenyl)piperidine hydrochloride has been thoroughly documented, with detailed HPLC and GC-MS data available to support quality control. This transparency meets the increasing demand for "fully characterized research chemicals"—a frequent requirement in academic and industrial research settings. The availability of comprehensive spectral data facilitates its adoption in various research programs.

Looking forward, the applications of 3-(3-Methylphenyl)piperidine hydrochloride may expand into new areas of pharmaceutical development, particularly in the design of next-generation therapeutics. Its structural flexibility allows for further derivatization, addressing the persistent search for "versatile building blocks in medicinal chemistry". As research continues, this compound is poised to maintain its importance in the chemical research landscape.

• 19748-94-8(Piperidine, 3-phenyl-1-propyl-, hydrochloride)
• 72811-36-0(3,4-diphenyl-1-azabicyclo[2.2.2]octane hydrochloride)
• 430461-56-6((3R)-3-phenylpiperidine)
• 65367-98-8(3-(4-Methylphenyl)piperidine Hydrochloride)
• 19509-09-2(3-Phenylpiperidine hydrochloride)
• 3973-62-4(3-Phenylpiperidine)
• 83949-39-7(4-Piperidinemethanamine,4-phenyl-, hydrochloride (1:2))
• 59349-71-2((3S)-3-phenylpiperidine)
• 79412-51-4(Piperidine, 3-(3-methylphenyl)-1-propyl-, hydrochloride)
• 7475-55-0( )