• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119

tert-butyl N-ethyl-N-(piperidin-3-yl)carbamate: A Comprehensive Overview

The compound tert-butyl N-ethyl-N-(piperidin-3-yl)carbamate, identified by the CAS number 1184540-14-4, is a versatile and intriguing molecule with a wide range of applications in various fields. This compound, belonging to the class of carbamates, has garnered significant attention in recent years due to its unique chemical properties and potential uses in drug design, materials science, and beyond. In this article, we will delve into the structural characteristics, synthesis methods, applications, and recent advancements related to this compound.

Firstly, it is essential to understand the molecular structure of tert-butyl N-ethyl-N-(piperidin-3-yl)carbamate. The molecule consists of a central carbamate group (-O-CO-O-) attached to a tert-butyl group and a piperidin-3-yl group, which is further substituted with an ethyl group. This combination of functional groups imparts the compound with unique reactivity and stability. The tert-butyl group contributes to the molecule's hydrophobicity, while the piperidine ring introduces rigidity and potential sites for further functionalization. Recent studies have highlighted the importance of such structural features in enhancing the bioavailability and pharmacokinetic properties of drugs.

The synthesis of tert-butyl N-ethyl-N-(piperidin-3-yl)carbamate typically involves multi-step reactions, often starting from readily available starting materials such as tert-butanol and ethylamine. One common approach involves the formation of an intermediate carbamate ester, followed by nucleophilic substitution with the piperidine derivative. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses, reducing production costs and minimizing waste. For instance, researchers have explored the use of enzymes like lipases for catalyzing key steps in the synthesis process, demonstrating improved yields and selectivity.

One of the most promising applications of tert-butyl N-ethyl-N-(piperidin-3-yl)carbamate lies in its use as a precursor in drug development. The compound's ability to act as a bioisostere or a prodrug has been extensively studied. A prodrug is an inactive derivative of a drug that is converted into its active form within the body through enzymatic or chemical processes. By incorporating this carbamate into drug molecules, researchers can enhance drug delivery efficiency, reduce side effects, and improve patient compliance. Recent clinical trials have shown that drugs derived from this compound exhibit improved pharmacokinetic profiles compared to their non-prodrug counterparts.

In addition to its role in pharmaceuticals, tert-butyl N-ethyl-N-(piperidin-3-yl)carbamate has found applications in materials science. Its ability to form stable polymers through step-growth polymerization has led to its use in creating advanced coatings and adhesives. Researchers have reported that polymers synthesized using this compound exhibit excellent mechanical properties and resistance to environmental degradation. Furthermore, its compatibility with various solvents makes it suitable for use in high-performance composites.

The environmental impact of tert-butyl N-ethyl-N-(piperidin-3-yl)carbamate has also been a topic of recent research interest. Studies have shown that under certain conditions, such as exposure to UV light or microbial activity, the compound undergoes biodegradation into non-toxic byproducts. This biodegradability makes it an attractive alternative to traditional persistent organic compounds used in industrial applications. However, further research is needed to fully understand its long-term environmental effects and ensure sustainable practices during production and disposal.

In conclusion, tert-butyl N-ethyl-N-(piperidin-3-yl)carbamate, CAS number 1184540-14

• 147539-41-1(tert-butyl 4-(methylamino)piperidine-1-carboxylate)
• 172603-05-3(tert-butyl N-(3-piperidyl)carbamate)
• 184637-48-7(tert-butyl 3-aminopiperidine-1-carboxylate)
• 188111-79-7(tert-butyl (3R)-3-aminopiperidine-1-carboxylate)
• 177911-87-4(Tert-butyl 2-(aminomethyl)pyrrolidine-1-carboxylate)
• 186550-13-0(1-Boc-3-aminopyrrolidine)
• 207405-68-3(tert-butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)