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Comprehensive Overview of 3-(3-Pyridinyl)-1H-Indazol-5-amine (CAS No. 1176535-07-1): Properties, Applications, and Market Insights

The compound 3-(3-Pyridinyl)-1H-Indazol-5-amine (CAS No. 1176535-07-1) is a heterocyclic organic molecule that has garnered significant attention in pharmaceutical and biochemical research. This pyridine-indazole hybrid structure exhibits unique chemical properties, making it valuable for various applications, particularly in drug discovery and development. The molecular formula C12H10N4 and molecular weight of 210.24 g/mol position this compound as a promising candidate for medicinal chemistry applications.

Recent studies highlight the growing interest in indazole derivatives like 3-(3-Pyridinyl)-1H-Indazol-5-amine due to their diverse biological activities. The presence of both pyridine and indazole moieties in its structure contributes to its potential as a pharmacophore in designing novel therapeutic agents. Researchers are particularly interested in its role as a kinase inhibitor scaffold, with applications in oncology and inflammatory disease research.

The synthesis of 3-(3-Pyridinyl)-1H-Indazol-5-amine typically involves multi-step organic reactions, with careful control of reaction conditions to ensure high purity. Analytical characterization using techniques such as HPLC, NMR, and mass spectrometry confirms the structural integrity of this compound. Its solubility profile shows moderate solubility in polar organic solvents like DMSO and methanol, while being less soluble in water, which is crucial information for formulation scientists.

In pharmaceutical applications, this compound serves as a valuable building block for drug discovery programs. The amino group at the 5-position of the indazole ring provides an excellent handle for further chemical modifications, allowing medicinal chemists to create diverse analogs with potentially improved pharmacological properties. Current research focuses on its potential as a selective kinase modulator, with particular interest in its interactions with various cancer-related protein targets.

The global market for specialty chemical intermediates like 3-(3-Pyridinyl)-1H-Indazol-5-amine has shown steady growth, driven by increasing R&D investments in pharmaceutical companies. Market analysts project continued demand for such heterocyclic compounds, especially those with potential therapeutic applications. The compound's stability under standard storage conditions (typically recommended at 2-8°C) makes it suitable for long-term research programs.

Quality control measures for 3-(3-Pyridinyl)-1H-Indazol-5-amine emphasize the importance of purity assessment, with most commercial suppliers offering ≥95% purity grades. Researchers should verify the compound's identity through appropriate spectroscopic methods before use in sensitive biological assays. The development of robust synthetic protocols has enabled scale-up production while maintaining consistent quality, addressing the needs of both academic and industrial researchers.

Emerging trends in precision medicine and targeted therapy development have increased the relevance of compounds like 3-(3-Pyridinyl)-1H-Indazol-5-amine. Its structural features align well with current drug design strategies that emphasize molecular specificity and reduced off-target effects. Several patent applications have recently featured derivatives of this core structure, indicating its growing importance in intellectual property landscapes.

Safety considerations for handling 3-(3-Pyridinyl)-1H-Indazol-5-amine follow standard laboratory protocols for organic compounds. While not classified as highly hazardous, proper personal protective equipment including gloves and safety glasses is recommended during manipulation. Material safety data sheets provide detailed handling instructions specific to this chemical entity.

The future research directions for 3-(3-Pyridinyl)-1H-Indazol-5-amine include exploration of its structure-activity relationships and potential applications in combination therapies. The compound's modular structure allows for systematic modifications to optimize pharmacokinetic properties, making it a versatile tool in modern medicinal chemistry. Continued investigation of its biological targets may reveal new therapeutic opportunities in areas such as autoimmune disorders and metabolic diseases.

For researchers sourcing 3-(3-Pyridinyl)-1H-Indazol-5-amine, it's essential to verify suppliers' credentials and quality control processes. The compound is available through several specialty chemical providers, with options for custom synthesis and bulk quantities. Documentation including certificates of analysis should accompany all purchases to ensure material suitability for intended applications.

In conclusion, 3-(3-Pyridinyl)-1H-Indazol-5-amine (CAS No. 1176535-07-1) represents an important chemical entity with broad potential in pharmaceutical research and development. Its unique structural features and demonstrated biological relevance position it as a valuable asset in the ongoing search for novel therapeutic agents. As research continues to uncover new applications for this compound, its significance in drug discovery pipelines is likely to grow.

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