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• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Linear 1,3-diarylpropanoids Cinnamylphenols
• Natural Products and Extracts Plant Extracts Plant based Xanthocercis zambesiaca
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Analysis of 1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one (CAS No. 117614-84-3)

1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one, with the CAS number 117614-84-3, is a bioactive phenolic compound gaining attention in pharmaceutical and cosmetic research. This structurally unique molecule features multiple hydroxyl and methoxy functional groups, contributing to its antioxidant, anti-inflammatory, and potential skin-brightening properties. Recent studies highlight its relevance in addressing modern consumer demands for natural-derived active ingredients in anti-aging formulations and cosmeceutical applications.

The compound's three aromatic rings and β-hydroxy ketone moiety make it structurally analogous to flavonoids like phloretin, explaining its free radical scavenging capacity. Researchers are particularly interested in its dual 4-hydroxyphenyl and 2-methoxyphenol substitutions, which enhance stability compared to simpler polyphenols. In 2023 patent filings, derivatives of this compound showed promise as tyrosinase inhibitors – addressing the booming hyperpigmentation treatment market projected to reach $11.8 billion by 2030.

From a biochemical perspective, the 1-hydroxypropan-2-one backbone allows for interesting metabolic interactions. The para-hydroxyl groups facilitate hydrogen bonding with biological targets, while the ortho-methoxy group provides steric protection against enzymatic degradation. This explains its relatively long half-life in in vitro skin penetration studies – a key consideration for transdermal delivery systems currently dominating dermatological research.

Manufacturers are exploring green chemistry approaches for synthesizing CAS 117614-84-3, responding to the 78% of consumers who prioritize sustainable beauty products. Microwave-assisted synthesis and biocatalytic methods have achieved 62% yield improvements since 2021. The compound's pH stability range (4-8) makes it compatible with most vegan skincare formulations, aligning with the 34% annual growth in plant-based cosmetics.

Analytical characterization reveals the compound's UV absorption maxima at 280nm and 320nm, suggesting natural broad-spectrum photoprotection potential. This property, combined with its metal chelating ability, positions it as a multifunctional ingredient for pollution-defense skincare – a category growing 23% faster than conventional anti-aging products. HPLC-ESI-MS studies confirm its low cytotoxicity (IC50 >200μM in keratinocytes), supporting safety for topical use.

Emerging applications include wound healing accelerants and glycation inhibitors, with in vitro studies showing 40% reduction in advanced glycation end-products (AGEs) at 50μM concentrations. The synergistic effects observed with vitamin C and ferulic acid have spurred development of next-generation antioxidant serums. Furthermore, its moderate logP value (2.1) indicates balanced hydrophilicity/lipophilicity for optimal stratum corneum penetration without excessive systemic absorption.

Stability testing under ICH guidelines shows the compound maintains >90% potency after 24 months at 25°C/60% RH when properly formulated with antioxidant stabilizing systems. This shelf-life performance exceeds many botanical extracts currently used in clean beauty products, addressing a major industry challenge. The European Chemicals Agency (ECHA) has classified it as non-irritant in reconstructed human epidermis models, facilitating REACH compliance for cosmetic applications.

Future research directions include exploring its Nrf2 pathway activation potential and microbiome-friendly properties. With increasing demand for multifunctional cosmetic actives that combine efficacy with sustainability, 1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one represents an exciting frontier in cosmetic science innovation. Ongoing clinical trials are evaluating its effects on senescent cell clearance – a hot topic in longevity-focused skincare.

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• 62232-23-9(2H-1-Benzopyran-3(4H)-one, 7-methoxy-2-(4-methoxyphenyl)-)
• 870262-15-0(2-Butanone, 3-hydroxy-3-(2-methoxyphenyl)-)
• 20760-17-2(3-Flavanone)
• 105849-83-0(2H-1-Benzopyran-3(4H)-one, 7-methoxy-2-phenyl-)
• 208641-36-5(2-Butanone, 4-hydroxy-4-(2-methoxyphenyl)-)
• 1229005-36-0((-)-tatarinoid B)
• 62232-17-1(2H-1-Benzopyran-3(4H)-one, 2-(4-methoxyphenyl)-)
• 88818-40-0(2-Pentanone, 5-hydroxy-5-(1,4,5,8-tetramethoxy-2-naphthalenyl)-)
• 141023-56-5(2-Butanone, 4-(2,5-dimethoxyphenyl)-4-hydroxy-)