• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
• 4. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

Professional Introduction to 4-(4-Benzyloxyphenyl)benzonitrile (CAS No. 117571-49-0)

4-(4-Benzyloxyphenyl)benzonitrile, with the chemical formula C₂₁H₁₇NO, is a significant compound in the field of pharmaceutical chemistry and organic synthesis. This compound is characterized by its unique structural features, which include a benzonitrile moiety linked to a phenyl ring that is further substituted with a benzyloxy group. The presence of these functional groups makes it a versatile intermediate in the synthesis of various bioactive molecules.

The CAS number 117571-49-0 provides a unique identifier for this compound, ensuring accurate classification and referencing in scientific literature and industrial applications. The benzonitrile group is known for its ability to participate in nucleophilic addition reactions, while the benzyloxy group introduces hydrophobicity and can serve as a protecting group in synthetic pathways. These properties make 4-(4-Benzyloxyphenyl)benzonitrile a valuable building block in the development of new pharmaceuticals.

In recent years, there has been growing interest in the application of 4-(4-Benzyloxyphenyl)benzonitrile in medicinal chemistry. Its structural framework is conducive to the design of molecules with potential therapeutic effects. For instance, derivatives of this compound have been explored as inhibitors of enzymes involved in inflammatory pathways. The benzyloxyphenyl moiety, in particular, has shown promise in modulating the activity of targets such as kinases and phosphodiesterases, which are crucial in various disease mechanisms.

One of the most compelling aspects of 4-(4-Benzyloxyphenyl)benzonitrile is its role in the synthesis of small-molecule drugs. Researchers have leveraged its reactivity to develop novel compounds that exhibit improved pharmacokinetic properties compared to existing therapies. The benzonitrile group can be further functionalized to introduce additional substituents, allowing for fine-tuning of biological activity. This flexibility has led to several patents and ongoing clinical trials investigating the efficacy of molecules derived from this scaffold.

The pharmaceutical industry has also recognized the potential of 4-(4-Benzyloxyphenyl)benzonitrile in drug discovery programs. Its incorporation into libraries of compounds has facilitated high-throughput screening processes aimed at identifying new lead candidates. The compound’s ability to undergo cross-coupling reactions, such as Suzuki-Miyaura coupling, further enhances its utility as a synthetic intermediate. These reactions enable the rapid assembly of complex molecular structures, which would be otherwise challenging to achieve through traditional synthetic methods.

Recent advancements in computational chemistry have also highlighted the significance of 4-(4-Benzyloxyphenyl)benzonitrile in drug design. Molecular modeling studies have demonstrated that modifications to its structure can influence binding affinity and selectivity towards biological targets. This has spurred interest in developing computational tools that predict the behavior of such compounds before experimental synthesis. Such innovations are expected to accelerate the drug development pipeline and reduce costs associated with traditional trial-and-error approaches.

The long-tail keyword "synthesis of 4-(4-Benzyloxyphenyl)benzonitrile" underscores its importance as a synthetic intermediate. The compound’s accessibility through multi-step organic synthesis routes has made it a preferred choice for researchers aiming to explore novel chemical entities. Its stability under various reaction conditions further enhances its appeal, ensuring consistent yields and purity levels required for pharmaceutical applications.

In conclusion, 4-(4-Benzyloxyphenyl)benzonitrile (CAS No. 117571-49-0) represents a cornerstone in modern pharmaceutical chemistry. Its unique structural attributes and reactivity profile make it an indispensable tool for medicinal chemists seeking to develop innovative therapeutic agents. As research continues to uncover new applications for this compound, its significance in drug discovery is likely to grow even further.

• 503829-94-5(Benzonitrile, 4-[([1,1'-biphenyl]-4-yloxy)methyl]-)
• 57928-72-0(3-(Phenoxymethyl)benzonitrile)
• 52805-36-4(4-(Benzyloxy)benzonitrile)
• 431946-37-1(Benzonitrile, 4-(phenylmethoxy)-)
• 53658-04-1(Benzonitrile, 4,4'-[1,3-phenylenebis(methyleneoxy)]bis-)
• 57928-92-4(Benzonitrile, 4-[(4-cyanophenoxy)methyl]-)
• 53658-03-0(4-[[4-[(4-cyanophenoxy)methyl]phenyl]methoxy]benzonitrile)
• 336193-99-8(Benzonitrile, 3-[(4-methoxyphenyl)methoxy]-)
• 503829-92-3(Benzonitrile, 3-[([1,1'-biphenyl]-4-yloxy)methyl]-)
• 503829-93-4(Benzonitrile, 3-([1,1'-biphenyl]-4-ylmethoxy)-)