• 1. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 2. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 3. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 4. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 5. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-pyridylmethylamines

Research Brief on (5-bromo-3-nitro-2-pyridyl)methanamine (CAS: 1174007-35-2) and Its Applications in Chemical Biology and Pharmaceutical Research

The compound (5-bromo-3-nitro-2-pyridyl)methanamine (CAS: 1174007-35-2) has recently gained attention in chemical biology and pharmaceutical research due to its versatile applications as a key intermediate in the synthesis of bioactive molecules. This research brief provides an overview of the latest advancements related to this compound, focusing on its synthetic utility, biological relevance, and potential therapeutic applications.

Recent studies have highlighted the importance of (5-bromo-3-nitro-2-pyridyl)methanamine as a building block for the development of novel kinase inhibitors and other small-molecule therapeutics. The presence of both bromo and nitro functional groups on the pyridine ring makes this compound particularly valuable for further derivatization through cross-coupling reactions and nucleophilic substitutions, enabling the creation of diverse chemical libraries for drug discovery.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers utilized (5-bromo-3-nitro-2-pyridyl)methanamine as a precursor for the synthesis of selective JAK2 inhibitors. The compound's ability to serve as a scaffold for introducing various pharmacophores was demonstrated, with the resulting molecules showing promising activity in preclinical models of myeloproliferative disorders. The study reported IC50 values in the low nanomolar range for several derivatives, highlighting the compound's potential in targeted therapy development.

Another significant application was reported in chemical biology research, where (5-bromo-3-nitro-2-pyridyl)methanamine was employed as a key intermediate for the development of activity-based protein profiling (ABPP) probes. The compound's reactive handles allowed for efficient conjugation with reporter tags, enabling the selective labeling and identification of cysteine proteases in complex biological systems. This work, published in ACS Chemical Biology, demonstrated the compound's utility in proteome-wide studies of enzyme activity.

From a synthetic chemistry perspective, recent advances have focused on optimizing the preparation of (5-bromo-3-nitro-2-pyridyl)methanamine to improve yield and purity. A 2024 patent application describes an improved synthetic route that reduces the number of steps and minimizes the formation of byproducts, making the compound more accessible for large-scale pharmaceutical applications. The method employs a novel protecting group strategy that enhances the selectivity of the amination step.

In conclusion, (5-bromo-3-nitro-2-pyridyl)methanamine (CAS: 1174007-35-2) continues to demonstrate significant value in multiple areas of pharmaceutical research and chemical biology. Its dual functionality as both a synthetic intermediate and a potential pharmacophore makes it particularly valuable for drug discovery efforts. Ongoing research suggests that derivatives of this compound may lead to novel therapeutics for various diseases, particularly in the areas of oncology and inflammation.

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