• 1. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 4. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 5. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Hydrazines and derivatives Semicarbazides

Latest Research Advances on Semicarbazide-13C,15N2 Hydrochloride (CAS: 1173020-16-0) in Chemical Biology and Pharmaceutical Applications

Semicarbazide-13C,15N2 Hydrochloride (CAS: 1173020-16-0) is a stable isotope-labeled compound that has garnered significant attention in chemical biology and pharmaceutical research due to its utility as a tracer in metabolic studies and drug development. Recent studies have highlighted its role in elucidating reaction mechanisms, particularly in the context of carbonyl group modifications and nucleophilic addition reactions. The isotopic labeling (13C and 15N2) enables precise tracking of molecular transformations, making it invaluable for mass spectrometry-based analyses and pharmacokinetic studies.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the application of Semicarbazide-13C,15N2 Hydrochloride in the development of novel hydrazide-based inhibitors targeting bacterial enzymes. The researchers utilized the labeled compound to monitor the binding kinetics and stability of inhibitor-enzyme complexes, revealing insights into the structural determinants of inhibition. This work underscores the compound's potential in antibiotic discovery, particularly against multidrug-resistant pathogens.

In the field of cancer research, a recent preprint (2024) on bioRxiv explored the use of Semicarbazide-13C,15N2 Hydrochloride as a probe for detecting reactive carbonyl species (RCS) in tumor microenvironments. The study employed high-resolution LC-MS/MS to quantify RCS adducts, leveraging the isotopic signature of the labeled semicarbazide for unambiguous identification. The findings suggest that RCS accumulation may serve as a biomarker for oxidative stress in certain cancer types, opening new avenues for diagnostic and therapeutic strategies.

From a synthetic chemistry perspective, advancements in the production of Semicarbazide-13C,15N2 Hydrochloride have been reported, with improved yields (>85%) and purity (>98%) achieved through optimized condensation reactions between 13C-urea and 15N2-hydrazine derivatives. These process improvements, detailed in a 2023 Organic Process Research & Development article, address previous challenges in scaling up the synthesis of isotopically labeled semicarbazide derivatives.

Ongoing clinical research is investigating the safety profile of semicarbazide-containing compounds, with particular attention to potential neurotoxic effects. A 2024 review in Chemical Research in Toxicology analyzed structure-activity relationships using Semicarbazide-13C,15N2 Hydrochloride as a reference standard, providing crucial data for risk assessment in drug development pipelines. The isotopic labeling allowed for distinguishing endogenous versus exogenous semicarbazide derivatives in biological matrices.

Future research directions highlighted in recent literature include the application of Semicarbazide-13C,15N2 Hydrochloride in proteomics (for identifying carbonylated proteins) and in the development of PET tracers for imaging applications. The compound's versatility as a biochemical tool continues to expand as analytical techniques become more sensitive to isotopic patterns.

• 873205-62-0(Semicarbazide-13C,15N2 Hydrochloride)
• 201996-18-1(Hydrazinecarboxamide-13C Monohydrochloride)
• 1173147-76-6(Hydrazine-?1,?2-?15N2-?carboxamide-?13C)
• 57-56-7(Semicarbazide)
• 497-18-7(Carbohydrazide)
• 563-41-7(Semicarbazide hydrochloride)
• 32315-17-6(Hydrazinecarboxamide, hydrobromide (2:1))
• 18396-65-1(Semicarbazide hydrochloride)
• 20813-06-3(Hydrazinecarboxamide, conjugate monoacid (9CI))
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)