• 1. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 2. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 3. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 4. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 5. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Imidazoles Substituted imidazoles

Comprehensive Guide to Metronidazole-13C2,15N2 (CAS No. 1173020-03-5): Applications, Stability, and Analytical Insights

In the realm of isotopic labeling and pharmaceutical research, Metronidazole-13C2,15N2 (CAS No. 1173020-03-5) stands out as a critical tool for advanced analytical studies. This stable isotope-labeled compound, derived from the widely used antibiotic Metronidazole, incorporates carbon-13 (13C) and nitrogen-15 (15N) isotopes at specific positions, enhancing its utility in mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Researchers and laboratories increasingly seek isotopically labeled standards like Metronidazole-13C2,15N2 to ensure precision in pharmacokinetic studies, drug metabolism research, and environmental monitoring.

The growing demand for stable isotope-labeled compounds aligns with trends in personalized medicine and traceability in pharmaceutical development. A common question in scientific forums is: "How does Metronidazole-13C2,15N2 improve quantification accuracy in LC-MS/MS?" The answer lies in its ability to serve as an internal standard, minimizing matrix effects and ion suppression. Unlike non-labeled Metronidazole, this variant exhibits nearly identical chemical properties while providing distinct mass spectral signatures, enabling reliable detection even in complex biological matrices like plasma or urine.

From a synthetic chemistry perspective, Metronidazole-13C2,15N2 (CAS 1173020-03-5) is synthesized through meticulous incorporation of 13C and 15N isotopes during key reaction steps. This process ensures high isotopic enrichment (>98%) and chemical purity, meeting stringent requirements for Good Laboratory Practice (GLP) and FDA submissions. Recent publications highlight its role in elucidating the metabolic pathways of nitroimidazole antibiotics, addressing concerns about microbial resistance—a hot topic in infectious disease research.

Stability is another focal point for users. Proper storage of Metronidazole-13C2,15N2—typically at -20°C in amber vials—preserves its integrity for years. Analytical chemists frequently search for "degradation products of isotope-labeled Metronidazole", underscoring the need for rigorous quality control. Accelerated stability studies confirm that the compound remains stable under recommended conditions, with no significant degradation observed even after 24 months.

Beyond research, regulatory agencies emphasize traceability in drug development. The unique CAS registry number (1173020-03-5) for Metronidazole-13C2,15N2 facilitates unambiguous identification in global databases. This aligns with ISO guidelines for chemical identification, a recurring theme in compliance-driven industries. As LC-MS/MS becomes mainstream in clinical labs, the compound’s utility extends to therapeutic drug monitoring (TDM), particularly for patients receiving high-dose Metronidazole regimens.

Environmental scientists also leverage Metronidazole-13C2,15N2 to track pharmaceutical residues in wastewater. With increasing scrutiny on antibiotic pollution, this labeled analog helps distinguish parent compounds from transformation products in environmental samples. A 2023 study demonstrated its effectiveness in quantifying sub-ppb levels of Metronidazole in aquatic systems, addressing ecological concerns tied to antimicrobial resistance (AMR).

In summary, Metronidazole-13C2,15N2 (CAS 1173020-03-5) exemplifies the intersection of isotopic chemistry and modern analytics. Its applications span drug development, environmental science, and clinical diagnostics—all areas where precision and reliability are paramount. As research evolves, this compound will remain indispensable for scientists tackling challenges like AMR and personalized therapeutics.

• 443-48-1(Metronidazole)
• 1077-93-6(2-Methyl-5-nitroimidazole-1-propanol)
• 16156-94-8(O-Hydroxyethyl Metronidazole)
• 70028-95-4(Ternidazole Hydrochloride)
• 62580-80-7(3-Deschloro-3-hydroxy Ornidazole)
• 110321-22-7(Platinum,amminedichloro(2-methyl-5-nitro-1H-imidazole-1-ethanol-N3)-, (SP-4-3)- (9CI))
• 3366-95-8(secnidazole)
• 4812-40-2(Hydroxy Metronidazole)
• 69198-10-3(1H-Imidazole-1-ethanol,2-methyl-5-nitro-, hydrochloride (1:1))
• 84151-71-3(Platinum,dichlorobis(2-methyl-5-nitro-1H-imidazole-1-ethanol-kN3)-, (SP-4-2)-)