• 1. Synthesis of 1α-hydroxycorticosterone
  David E. Kime J. Chem. Soc. Perkin Trans. 1 1975 2371
• 2. Synthesis of 11-deoxy-18-hydroxycorticosterone and 18-hydroxycorticosterone 21-acetates
  Derek H. R. Barton,Michael J. Day,Robert H. Hesse,Maurice M. Pechet J. Chem. Soc. Perkin Trans. 1 1975 2252
• 3. Improved syntheses of aldosterone
  Derek H. R. Barton,Nilaj K. Basu,Michael J. Day,Robert H. Hesse,Maurice M. Pechet,Alvin N. Starratt J. Chem. Soc. Perkin Trans. 1 1975 2243
• 4. 18-Substituted steroids. Part 5. Further studies on the synthesis of 11β,18,21-trihydroxypregn-4-ene-3,20-dione (‘18-hydroxycorticoster-one’)
  David N. Kirk,Christopher J. Slade J. Chem. Soc. Perkin Trans. 1 1980 2591
• 5. Index of subjects, 1975
  J. Chem. Soc. Perkin Trans. 1 1975 2557

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Gluco/mineralocorticoids, progestogins and derivatives
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Pregnane steroids Gluco/mineralocorticoids, progestogins and derivatives

Professional Introduction to Corticosterone 21-Acetate (CAS No. 1173-26-8)

Corticosterone 21-Acetate, a derivative of the naturally occurring steroid hormone corticosterone, is a compound of significant interest in the field of pharmaceutical chemistry and endocrinology. The chemical structure of Corticosterone 21-Acetate features an acetylated group at the 21-position, which modifies its pharmacokinetic properties and biological activity. With a CAS number of 1173-26-8, this compound has been extensively studied for its potential therapeutic applications, particularly in the modulation of inflammatory responses and immunomodulatory effects.

The synthesis of Corticosterone 21-Acetate involves a series of well-established organic reactions, including oxidation and acetylation processes. The precise modification at the 21-position enhances the stability and bioavailability of the compound, making it a valuable intermediate in the development of novel steroid-based drugs. Recent advancements in synthetic methodologies have improved the yield and purity of Corticosterone 21-Acetate, facilitating its use in both preclinical and clinical research.

In recent years, Corticosterone 21-Acetate has garnered attention for its role in investigating the mechanisms of steroid hormone action. Studies have demonstrated that this compound exhibits potent anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6. The ability to modulate these pathways makes Corticosterone 21-Acetate a promising candidate for treating chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.

Moreover, research has highlighted the potential of Corticosterone 21-Acetate in immunomodulatory therapies. Its selective action on immune cells has been observed to dampen excessive immune responses while preserving essential immune functions. This balance is crucial in developing treatments for autoimmune disorders such as multiple sclerosis and systemic lupus erythematosus. The compound's ability to interact with specific nuclear receptors, including glucocorticoid receptors, further underscores its therapeutic potential.

Another area of interest is the application of Corticosterone 21-Acetate in cancer research. Preliminary studies suggest that this derivative may exhibit antitumor effects by inducing apoptosis in cancer cells and inhibiting their proliferation. The acetylated form enhances its solubility and cell membrane permeability, allowing for more efficient delivery to target tissues. These findings open new avenues for developing steroid-based anticancer agents.

The pharmacokinetic profile of Corticosterone 21-Acetate has also been thoroughly examined. Its moderate bioavailability and longer half-life compared to native corticosterone make it a suitable candidate for oral administration. Additionally, its metabolic stability ensures prolonged activity within the body, reducing the frequency of dosing required. These attributes are critical for patient compliance and therapeutic efficacy.

In conclusion, Corticosterone 21-Acetate (CAS No. 1173-26-8) is a versatile compound with significant implications in pharmaceutical research and development. Its unique chemical structure and biological activity position it as a valuable tool in addressing various medical conditions, particularly those involving inflammation and immune dysregulation. As research continues to uncover new therapeutic applications, Corticosterone 21-Acetate is poised to play a pivotal role in shaping future treatments.

• 71-58-9(Medroxyprogesterone acetate)
• 56-47-3(Deoxy Corticosterone Acetate)
• 302-23-8(Progesterone Acetate)
• 434-05-9(Metenolone acetate)
• 1045-69-8(Testosterone acetate)
• 1449-61-2(Androst-5-ene-7,17-dione, 3-(acetyloxy)-, (3beta)-)
• 50-04-4(Cortisone acetate)
• 2224-33-1(Vinyltris(methylethylketoximine)silane)
• 630-56-8(Hydroxyprogesterone caproate)
• 50-03-3(Hydrocortisone acetate)