• 1. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 2. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 5. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles

Introduction to 4-Bromo-1H-indole-7-carbonitrile (CAS No. 1167055-46-0)

4-Bromo-1H-indole-7-carbonitrile, identified by the Chemical Abstracts Service Number (CAS No.) 1167055-46-0, is a significant intermediate in the field of pharmaceutical and agrochemical research. This compound belongs to the indole family, a heterocyclic aromatic structure that has garnered considerable attention due to its diverse biological activities and synthetic utility. The presence of both bromine and nitrile functional groups makes it a versatile building block for further chemical modifications, enabling the development of novel molecules with tailored properties.

The indole core is a privileged scaffold in medicinal chemistry, known for its role in various bioactive compounds. Its aromatic system can interact with biological targets in multiple ways, making it a preferred choice for drug design. The introduction of a bromine atom at the 4-position and a nitrile group at the 7-position enhances the reactivity of this indole derivative, facilitating further functionalization through cross-coupling reactions, nucleophilic substitutions, and other transformations.

In recent years, 4-Bromo-1H-indole-7-carbonitrile has been extensively studied for its potential applications in the synthesis of bioactive molecules. One notable area of research involves its use as a precursor in the development of small-molecule inhibitors targeting various therapeutic pathways. For instance, studies have demonstrated its utility in generating indole-based compounds that exhibit inhibitory effects on enzymes such as kinases and phosphodiesterases. These enzymes are often implicated in diseases like cancer, inflammation, and neurological disorders, making them attractive drug targets.

Moreover, the bromo and nitrile substituents on the indole ring provide handles for further chemical manipulation. The bromine atom can undergo palladium-catalyzed cross-coupling reactions with aryl halides or organometallic reagents, allowing for the introduction of diverse aryl groups. On the other hand, the nitrile group can be hydrolyzed to an amide or reduced to an amine, expanding the range of possible derivatives. Such versatility makes 4-Bromo-1H-indole-7-carbonitrile a valuable reagent in synthetic organic chemistry.

Recent advancements in drug discovery have highlighted the importance of indole derivatives in addressing unmet medical needs. Researchers have leveraged the structural features of indoles to develop compounds with enhanced pharmacological profiles. For example, modifications at the 3- and 5-positions of the indole ring have been explored to optimize binding affinity and selectivity. The compound's ability to serve as a scaffold for such modifications underscores its significance in medicinal chemistry.

The carbonitrile group in 4-Bromo-1H-indole-7-carbonitrile also contributes to its reactivity and functionality. Carbonitriles can participate in various transformations, including nucleophilic addition reactions and cycloadditions, which are useful for constructing complex molecular architectures. Additionally, they can be converted into other functional groups such as carboxylic acids or esters through hydrolysis or esterification reactions. This adaptability makes it an indispensable component in multi-step synthetic routes.

In academic research, 4-Bromo-1H-indole-7-carbonitrile has been employed in exploring new synthetic methodologies and developing novel catalysts. Its incorporation into libraries of compounds has enabled high-throughput screening efforts aimed at identifying bioactive molecules with potential therapeutic value. Such studies not only contribute to fundamental knowledge but also provide leads for further optimization by medicinal chemists.

The agrochemical sector has also recognized the utility of this compound as a precursor for developing novel pesticides and herbicides. Indole derivatives are known to possess pesticidal properties due to their ability to interfere with metabolic pathways in pests. By modifying the structure of 4-Bromo-1H-indole-7-carbonitrile, researchers aim to create compounds that are more effective and environmentally friendly alternatives to existing agrochemicals.

From a chemical synthesis perspective, 4-Bromo-1H-indole-7-carbonitrile exemplifies the importance of functional group interplay in designing versatile intermediates. The combination of bromine and nitrile not only enhances reactivity but also provides multiple pathways for structural diversification. This duality is particularly valuable in drug discovery pipelines where rapid access to structurally diverse compounds is essential.

The compound's stability under various reaction conditions further underscores its utility as a synthetic intermediate. It remains robust during thermal and photochemical treatments, allowing for its use in both classical organic synthesis and modern techniques such as flow chemistry. This stability ensures consistent yields and purity levels, which are critical for industrial applications.

In conclusion,4-Bromo-1H-indole-7-carbonitrile (CAS No. 1167055-46-0) is a multifaceted compound with broad applications across pharmaceuticals and agrochemicals. Its unique structural features—specifically the bromo and nitrile substituents—make it an invaluable intermediate for generating structurally diverse bioactive molecules. Ongoing research continues to uncover new synthetic strategies and applications for this compound, reinforcing its importance in modern chemical synthesis.

• 374633-29-1(4-Bromo-1H-indole-6-carbonitrile)
• 642477-82-5(4-Bromoquinoline-6-carbonitrile)
• 1242063-18-8(4-Bromoquinoline-7-carbonitrile)
• 903131-13-5(4-Bromo-1H-indole-3-carbonitrile)
• 90271-86-6(5-bromo-1H-indole-3-carbonitrile)
• 36075-68-0(4-Bromo-8-methylquinoline)
• 224434-83-7(6-Bromo-3-cyanoindole)
• 507476-70-2(5-Bromoquinoline-8-carbonitrile)
• 936092-87-4(4-Bromo-7-methyl-1H-indole)
• 1375108-40-9(7-Bromoquinoline-3-carbonitrile)