• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 3. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 4. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
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• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Nitrobenzoic acids and derivatives

Methyl 4-fluoro-2-methyl-5-nitrobenzoate: A Comprehensive Overview

Methyl 4-fluoro-2-methyl-5-nitrobenzoate, also known by its CAS number 1163287-01-1, is a compound of significant interest in the field of organic chemistry. This compound is a methyl ester derivative of 4-fluoro-2-methyl-5-nitrobenzoic acid, and its structure features a benzene ring substituted with a fluorine atom at the para position, a methyl group at the ortho position, and a nitro group at the meta position. The combination of these substituents makes this compound unique and versatile for various applications in both academic and industrial settings.

Recent studies have highlighted the potential of Methyl 4-fluoro-2-methyl-5-nitrobenzoate in drug discovery and development. The presence of the nitro group is particularly significant, as it can act as an electron-withdrawing group, influencing the electronic properties of the molecule. This makes it an attractive candidate for designing bioactive compounds with specific pharmacological profiles. For instance, researchers have explored its role in anti-inflammatory and anticancer drug design, where the nitro group can modulate the activity of key enzymes or receptors.

In addition to its pharmaceutical applications, Methyl 4-fluoro-2-methyl-5-nitrobenzoate has shown promise in materials science. Its ability to form stable ester linkages makes it a valuable precursor for synthesizing advanced materials such as polymers or nanoparticles. Recent advancements in green chemistry have also led to the exploration of this compound as a sustainable alternative in organic synthesis processes.

The synthesis of Methyl 4-fluoro-2-methyl-5-nitrobenzoate typically involves multi-step reactions, often starting from fluorobenzene derivatives. The introduction of the nitro group is a critical step and can be achieved through various methods, including nitration using mixed acids or electrophilic substitution reactions. The optimization of these reaction conditions has been a focus of recent research, aiming to improve yield and selectivity while minimizing environmental impact.

From an analytical standpoint, Methyl 4-fluoro-2-methyl-5-nitrobenzoate has been extensively studied using modern spectroscopic techniques such as NMR and IR spectroscopy. These studies have provided valuable insights into its molecular structure and stability under different conditions. Furthermore, computational chemistry approaches have been employed to predict its reactivity and interaction with biological systems, further enhancing our understanding of its potential applications.

In conclusion, Methyl 4-fluoro-2-methyl-5-nitrobenzoate is a multifaceted compound with diverse applications across various fields. Its unique structural features and reactivity make it an invaluable tool for researchers in organic chemistry, pharmacology, and materials science. As ongoing research continues to uncover new possibilities for this compound, its role in advancing scientific knowledge and technological innovation is expected to grow significantly.

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• 63299-56-9(BENZOIC ACID, 4-FLUORO-3,5-DINITRO-, METHYL ESTER)
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• 1123172-87-1(Methyl 3,5-difluoro-4-nitrobenzoate)
• 914347-91-4(Ethyl 3-Fluoro-4-nitrobenzoate)