• 1. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 2. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 4. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 5. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

Introduction to 5-bromo-3-fluoro-2-methyl-pyridine (CAS No. 1162674-74-9)

5-bromo-3-fluoro-2-methyl-pyridine, with the CAS number 1162674-74-9, is a versatile compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique bromine, fluorine, and methyl substituents on the pyridine ring, which confer it with distinct chemical and biological properties. The interest in 5-bromo-3-fluoro-2-methyl-pyridine stems from its potential applications in drug discovery and development, particularly as a building block for the synthesis of more complex molecules with therapeutic value.

The chemical structure of 5-bromo-3-fluoro-2-methyl-pyridine is noteworthy for its functional groups. The bromine atom at the 5-position and the fluorine atom at the 3-position provide opportunities for further chemical modifications, while the methyl group at the 2-position adds steric hindrance and influences the compound's reactivity. These features make 5-bromo-3-fluoro-2-methyl-pyridine an attractive starting material for a variety of synthetic routes, including cross-coupling reactions and nucleophilic substitutions.

In recent years, there has been a surge in research focusing on the use of halogenated pyridines in medicinal chemistry. Studies have shown that compounds derived from 5-bromo-3-fluoro-2-methyl-pyridine exhibit promising biological activities, including anti-inflammatory, anti-cancer, and anti-viral properties. For instance, a study published in the Journal of Medicinal Chemistry reported that a derivative of 5-bromo-3-fluoro-2-methyl-pyridine demonstrated potent inhibition of a specific kinase involved in cancer cell proliferation. This finding highlights the potential of this compound as a lead molecule for drug development.

The synthetic accessibility of 5-bromo-3-fluoro-2-methyl-pyridine is another factor contributing to its popularity in research laboratories. Various synthetic methods have been developed to produce this compound efficiently and in high yields. One common approach involves the bromination and fluorination of 2-methylpyridine, followed by purification through column chromatography or recrystallization. The ease of synthesis and purification makes 5-bromo-3-fluoro-2-methyl-pyridine readily available for large-scale production and further experimentation.

Beyond its use as a building block in organic synthesis, 5-bromo-3-fluoro-2-methyl-pyridine has also been explored for its potential as a ligand in metal-catalyzed reactions. Its ability to coordinate with transition metals such as palladium and nickel has led to its application in cross-coupling reactions, which are crucial for constructing complex organic molecules. For example, Suzuki-Miyaura coupling reactions involving 5-bromo-3-fluoro-2-methyl-pyridine have been used to synthesize biologically active compounds with high regioselectivity and stereoselectivity.

In addition to its synthetic utility, the physical properties of 5-bromo-3-fluoro-2-methyl-pyridine are well-documented. It is typically obtained as a colorless solid with a melting point ranging from 60 to 65°C. The compound is soluble in common organic solvents such as dichloromethane, ethanol, and dimethyl sulfoxide (DMSO), which facilitates its use in various chemical reactions. Its stability under standard laboratory conditions makes it suitable for long-term storage and repeated use.

The safety profile of 5-bromo-3-fluoro-2-methyl-pyridine is an important consideration for researchers working with this compound. While it is not classified as a hazardous material, standard laboratory safety protocols should be followed when handling it. Proper personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn to minimize exposure risks. Additionally, fume hoods should be used when performing reactions involving volatile solvents or generating potentially harmful vapors.

In conclusion, 5-bromo-3-fluoro-2-methyl-pyridine (CAS No. 1162674-74-9) is a valuable compound with diverse applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure and synthetic accessibility make it an ideal starting material for the development of novel therapeutic agents. Ongoing research continues to uncover new possibilities for this compound, underscoring its significance in modern drug discovery efforts.

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