• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Oxanes Oxanes
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Oxanes

Comprehensive Overview of 3-(bromomethyl)oxane (CAS No. 116131-44-3): Properties, Applications, and Industry Insights

3-(bromomethyl)oxane (CAS No. 116131-44-3) is a specialized organic compound gaining attention in pharmaceutical and agrochemical research due to its unique molecular structure. This brominated derivative of oxane features a reactive bromomethyl group, making it a valuable intermediate in synthetic chemistry. The compound's versatility stems from its ability to participate in nucleophilic substitution reactions, enabling the construction of complex heterocyclic frameworks.

Recent advancements in green chemistry have sparked interest in optimizing the synthesis of 3-(bromomethyl)oxane. Researchers are exploring catalytic methods to improve atom economy while reducing hazardous byproducts. The compound's molecular weight of 179.04 g/mol and boiling point characteristics make it suitable for various industrial processes. Its solubility profile in common organic solvents enhances its utility in multi-step synthetic routes.

In pharmaceutical applications, 116131-44-3 serves as a key building block for bioactive molecules. The oxane ring system contributes to improved metabolic stability in drug candidates, while the bromomethyl group allows for strategic functionalization. Current studies focus on its incorporation into central nervous system (CNS) targeted compounds and antimicrobial agents, addressing global health challenges.

The agrochemical industry utilizes 3-(bromomethyl)oxane in developing novel crop protection agents. Its structural features enable the creation of compounds with enhanced pesticidal activity and reduced environmental persistence. Manufacturers are particularly interested in its potential for sustainable agriculture solutions, aligning with the growing demand for eco-friendly formulations.

Analytical characterization of CAS 116131-44-3 typically involves GC-MS and NMR spectroscopy techniques. The compound displays distinctive spectral signatures, including characteristic proton resonances between 3.4-4.2 ppm for the bromomethyl protons. These analytical markers ensure quality control during production and application processes.

Storage and handling of 3-(bromomethyl)oxane require attention to moisture sensitivity and light exposure considerations. Best practices recommend amber glass containers under inert atmosphere when long-term stability is required. The compound's shelf life can be significantly extended through proper storage conditions, maintaining its reactivity for synthetic applications.

Emerging research explores the compound's potential in material science, particularly in polymer modification. The bromomethyl group's reactivity enables surface functionalization of various substrates, opening possibilities for advanced nanomaterials development. This interdisciplinary application demonstrates the compound's expanding role beyond traditional chemical synthesis.

Regulatory aspects of 116131-44-3 production emphasize compliance with REACH and other international chemical regulations. Manufacturers are increasingly adopting quality by design (QbD) principles to ensure consistent batch-to-batch performance. The compound's safety data profile continues to be refined through ongoing toxicological studies.

Market trends indicate growing demand for 3-(bromomethyl)oxane across Asia-Pacific regions, driven by expanding pharmaceutical and agrochemical sectors. Technological innovations in process chemistry are expected to improve production efficiency while reducing environmental impact. The compound's supply chain dynamics reflect the broader specialty chemicals market evolution.

Future research directions for CAS 116131-44-3 include exploration of its enantioselective applications and development of continuous flow synthesis methods. The scientific community continues to investigate its potential in medicinal chemistry platforms, particularly for targeted drug delivery systems. These advancements position 3-(bromomethyl)oxane as a compound of enduring significance in chemical research and industrial applications.

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