• 1. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 2. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 3. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 4. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 5. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219

Introduction to Trimethylamine N-oxide-d (CAS No. 1161070-49-0)

Trimethylamine N-oxide-d, with the chemical formula (CH?)?NO, is a deuterated derivative of trimethylamine N-oxide (TMAO), a compound of significant interest in the fields of chemistry, biochemistry, and pharmaceutical research. The inclusion of deuterium atoms (denoted by the suffix "-d") modifies the physical and chemical properties of the molecule, making it particularly valuable for studies involving isotope labeling and metabolic tracing. This introduction provides a comprehensive overview of Trimethylamine N-oxide-d, its applications, and its relevance in contemporary scientific research.

The molecular structure of Trimethylamine N-oxide-d consists of a trimethylamine core with an oxygen atom attached to one of the nitrogen atoms, forming an N-oxy functional group. The substitution of hydrogen atoms with deuterium in this compound enhances its stability under various analytical conditions, making it an ideal candidate for high-resolution spectroscopic techniques such as nuclear magnetic resonance (NMR) spectroscopy. This property is particularly advantageous in structural biology and drug metabolism studies, where precise molecular identification is crucial.

Trimethylamine N-oxide-d is primarily utilized as an internal standard or reference compound in analytical chemistry. Its deuterated form allows researchers to distinguish between naturally occurring TMAO and synthetic analogs, thereby improving the accuracy of quantitative analyses. In recent years, advancements in mass spectrometry have further highlighted the utility of Trimethylamine N-oxide-d in metabolomics research, enabling the detection and quantification of TMAO derivatives in biological samples with high sensitivity.

One of the most compelling applications of Trimethylamine N-oxide-d is in the study of gut microbiota metabolism. TMAO is a metabolite produced by certain gut bacteria from dietary precursors such as choline and carnitine. Elevated levels of TMAO have been associated with various cardiovascular diseases, inflammatory conditions, and metabolic syndromes. By employing Trimethylamine N-oxide-d as a labeled probe, researchers can track the biosynthesis and degradation pathways of TMAO within the human microbiome. This has led to significant insights into how gut health influences systemic physiological processes.

Recent studies have also explored the role of Trimethylamine N-oxide-d in drug development and pharmacokinetics. The deuterated version of TMAO exhibits altered pharmacokinetic profiles compared to its non-deuterated counterpart, which can influence drug absorption, distribution, metabolism, and excretion (ADME). This information is critical for optimizing drug formulations and predicting potential side effects. For instance, deuterated compounds often exhibit reduced metabolic clearance rates, potentially leading to longer half-lives and improved therapeutic efficacy.

The synthesis of Trimethylamine N-oxide-d presents unique challenges due to the need for precise isotopic labeling. Industrial-scale production typically involves catalytic hydrogenation or isotopic exchange reactions under controlled conditions to ensure high deuteration efficiency. Advances in synthetic methodologies have enabled the production of high-purity Trimethylamine N-oxide-d, meeting the stringent requirements of modern biochemical research.

In conclusion, Trimethylamine N-oxide-d (CAS No. 1161070-49-0) is a versatile compound with far-reaching implications in scientific research. Its applications span from analytical chemistry to microbiology and drug development, underscoring its importance as a tool for advancing our understanding of biological systems. As research continues to uncover new insights into TMAO metabolism and its health implications, Trimethylamine N-oxide-d will undoubtedly remain a cornerstone compound in interdisciplinary studies.

• 62637-93-8(Trimethylamine N-oxide dihydrate)
• 927186-49-0(N-Hydroxy-N-methylmethanamine--water (1/1))
• 65422-27-7(METHANAMINE, N,N-DIMETHYL-, N-OXIDE, HYDROBROMIDE)
• 5725-96-2(N,N-dimethylhydroxylamine)
• 6146-35-6(dimethyl nitroxide radical)
• 1184-78-7(Trimethylamine N-oxide)
• 7651-88-9(trimethylamine n-oxide hydrochloride)
• 136449-78-0(Methanamine, N,N-dimethyl-, N-oxide, monohydrate)
• 81752-56-9(Trimethylamine oxide; Hydroiodide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)