Cas no 1160430-66-9 (6-(4-Chlorophenoxy)pyridine-3-carbaldehyde)

6-(4-Chlorophenoxy)pyridine-3-carbaldehyde is a versatile chemical intermediate with a molecular formula of C12H8ClNO2. It features a pyridine core substituted at the 3-position with a formyl group and at the 6-position with a 4-chlorophenoxy moiety, enhancing its reactivity in organic synthesis. This compound is particularly valuable in pharmaceutical and agrochemical research due to its bifunctional structure, which allows for further derivatization via the aldehyde group and the aromatic ether linkage. Its high purity and stability make it suitable for use in cross-coupling reactions, nucleophilic additions, and as a precursor for heterocyclic compounds. The presence of both electron-withdrawing (chloro) and electron-donating (phenoxy) groups contributes to its unique electronic properties, facilitating applications in material science and medicinal chemistry.
6-(4-Chlorophenoxy)pyridine-3-carbaldehyde structure
1160430-66-9 structure
Product Name:6-(4-Chlorophenoxy)pyridine-3-carbaldehyde
CAS No:1160430-66-9
MF:C12H8ClNO2
MW:233.650422096252
MDL:MFCD12403521
CID:2115178
PubChem ID:23433264
Update Time:2025-11-01

6-(4-Chlorophenoxy)pyridine-3-carbaldehyde Chemical and Physical Properties

Names and Identifiers

    • 6-(4-chlorophenoxy)-3-Pyridinecarboxaldehyde
    • 6-(4-chlorophenoxy)pyridine-3-carbaldehyde
    • 3-Pyridinecarboxaldehyde, 6-(4-chlorophenoxy)-
    • MFCD12403521
    • EN300-296885
    • BS-44699
    • 1160430-66-9
    • AKOS017550228
    • 6-(4-Chlorophenoxy)nicotinaldehyde
    • DA-36827
    • SCHEMBL6142793
    • E78730
    • Z1415926049
    • 6-(4-Chlorophenoxy)pyridine-3-carbaldehyde
    • MDL: MFCD12403521
    • Inchi: 1S/C12H8ClNO2/c13-10-2-4-11(5-3-10)16-12-6-1-9(8-15)7-14-12/h1-8H
    • InChI Key: SMZLJRHNWGOQOS-UHFFFAOYSA-N
    • SMILES: ClC1C=CC(=CC=1)OC1C=CC(C=O)=CN=1

Computed Properties

  • Exact Mass: 233.0243562g/mol
  • Monoisotopic Mass: 233.0243562g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 3
  • Complexity: 229
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 39.2
  • XLogP3: 2.8

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6-(4-Chlorophenoxy)pyridine-3-carbaldehyde Related Literature

Additional information on 6-(4-Chlorophenoxy)pyridine-3-carbaldehyde

Comprehensive Overview of 6-(4-Chlorophenoxy)pyridine-3-carbaldehyde (CAS No. 1160430-66-9)

6-(4-Chlorophenoxy)pyridine-3-carbaldehyde (CAS No. 1160430-66-9) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This pyridine derivative features a 4-chlorophenoxy substituent and an aldehyde functional group, making it a versatile intermediate for synthesizing more complex molecules. Researchers and industries are increasingly exploring its potential due to its unique structural properties and reactivity.

The compound's molecular formula is C12H8ClNO2, with a molecular weight of 233.65 g/mol. Its chemical structure combines a pyridine ring with a chlorophenoxy group, which enhances its applicability in drug discovery and material science. Recent studies highlight its role in developing antimicrobial agents and catalytic processes, aligning with the growing demand for innovative solutions in healthcare and sustainable chemistry.

One of the most searched questions about 6-(4-Chlorophenoxy)pyridine-3-carbaldehyde revolves around its synthesis methods. The compound is typically prepared through cross-coupling reactions or oxidation of pyridine alcohols, with researchers optimizing yields and purity for industrial-scale production. Its aldehyde group offers a reactive site for further functionalization, making it a valuable building block in organic synthesis.

In the context of green chemistry, 6-(4-Chlorophenoxy)pyridine-3-carbaldehyde has been investigated for its potential in biodegradable materials and eco-friendly catalysts. This aligns with global trends toward sustainable practices, as industries seek alternatives to traditional petrochemical-derived intermediates. Its low toxicity profile and high stability further enhance its appeal for environmentally conscious applications.

Another hot topic is the compound's role in pharmaceutical intermediates. With the rise of precision medicine and targeted therapies, 6-(4-Chlorophenoxy)pyridine-3-carbaldehyde is being explored for its ability to modify bioactive molecules. Its chlorophenoxy moiety is particularly noteworthy, as it can influence the pharmacokinetic properties of drug candidates, improving their efficacy and safety profiles.

From a commercial perspective, the demand for 6-(4-Chlorophenoxy)pyridine-3-carbaldehyde is driven by its utility in high-value chemical production. Suppliers and manufacturers are increasingly listing this compound in catalogs, catering to the needs of research institutions and industrial laboratories. Quality control measures, such as HPLC analysis and spectroscopic characterization, ensure its suitability for advanced applications.

In summary, 6-(4-Chlorophenoxy)pyridine-3-carbaldehyde (CAS No. 1160430-66-9) represents a critical intermediate in modern chemistry. Its multifaceted applications—from drug development to sustainable materials—underscore its importance in addressing contemporary scientific and industrial challenges. As research progresses, this compound is poised to play an even greater role in innovation across multiple sectors.

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