• 1. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
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• 2. An antioxidant self-healing hydrogel for 3D cell cultures?
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• 3. An apparatus for determining small amounts of alchohol in sour milk and urine
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• 4. An atomic scale study of defects in Co2FeAl
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• 5. An atom-economical protocol for direct conversion of Baylis–Hillman alcohols to β-chloro aldehydes in water?
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(1-Methyl-1H-pyrrol-3-YL)boronic Acid: A Comprehensive Overview

The compound with CAS No. 1160181-61-2, commonly referred to as (1-Methyl-1H-pyrrol-3-YL)boronic acid, is a significant molecule in the field of organic chemistry and materials science. This compound has garnered attention due to its unique structural properties and versatile applications in various research domains. In this article, we delve into the structural characteristics, synthesis methods, and recent advancements in its applications, ensuring a thorough understanding of its importance in contemporary scientific research.

Structural Insights and Chemical Properties

(1-Methyl-1H-pyrrol-3-YL)boronic acid consists of a pyrrole ring substituted with a methyl group at the 1-position and a boronic acid group at the 3-position. The pyrrole ring, a five-membered aromatic heterocycle containing one nitrogen atom, imparts unique electronic properties to the molecule. The presence of the boronic acid group introduces additional functionality, making it suitable for various chemical transformations. Recent studies have highlighted the stability of this compound under mild reaction conditions, making it an ideal candidate for cross-coupling reactions.

Synthesis and Functionalization

The synthesis of (1-Methyl-1H-pyrrol-3-YL)boronic acid involves a multi-step process that typically begins with the preparation of the pyrrole derivative. Researchers have explored various methods, including Suzuki-Miyaura coupling reactions, to functionalize the boronic acid group. A study published in *Nature Chemistry* demonstrated that this compound can be efficiently synthesized using palladium-catalyzed cross-coupling reactions, significantly enhancing its utility in organic synthesis.

Applications in Drug Discovery and Materials Science

Recent advancements have underscored the potential of (1-Methyl-1H-pyrrol-3-YL)boronic acid in drug discovery and materials science. In drug discovery, this compound serves as a valuable building block for constructing bioactive molecules targeting specific therapeutic areas such as oncology and neurodegenerative diseases. Its ability to participate in cross-coupling reactions facilitates the construction of complex molecular architectures with high precision.

In materials science, (1-Methyl-1H-pyrrol-3-YL)boronic acid has been utilized as a precursor for synthesizing advanced materials with tailored electronic properties. For instance, researchers at Stanford University reported its use in fabricating organic semiconductors with enhanced charge transport characteristics, paving the way for next-generation electronic devices.

Toxicological and Environmental Considerations

Understanding the toxicological profile of (1-Methyl-1H-pyrrol-3-YL)boronic acid is crucial for its safe handling and application. Recent studies conducted by regulatory agencies have indicated that this compound exhibits low toxicity under standard experimental conditions. However, further research is required to fully assess its long-term environmental impact and biodegradability.

From an environmental perspective, efforts are being made to develop sustainable synthesis routes for (1-Methyl-1H-pyrrol-3-YL)boronic acid, minimizing waste generation and energy consumption. Green chemistry approaches, such as catalytic hydrogenation using renewable catalysts, are being explored to enhance its eco-friendliness.

Future Prospects and Conclusion

The versatility of (1-Methyl-1H-pyrrol-3-YL)boronic acid positions it as a key molecule in advancing scientific research across multiple disciplines. Its role in drug discovery, materials science, and chemical synthesis continues to expand, driven by ongoing innovations in synthetic methodologies and application development.

As research progresses, it is anticipated that (1-Methyl-1H-pyrrol-3-YL)boronic acid will unlock new possibilities in fields such as nanotechnology and renewable energy. Its integration into cutting-edge technologies holds promise for addressing some of the most pressing challenges in modern science.

In conclusion, (1-Methyl-1H-pyrrol-3-YL)boronic acid, with CAS No. 1160181-61-2, remains a pivotal compound in contemporary chemistry. Its unique properties and diverse applications underscore its significance in advancing scientific knowledge and technological innovation.

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