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  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 2. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
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  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

Comprehensive Overview of (2-Methyl-2H-indazol-5-yl)methanamine (CAS No. 1159511-63-3): Properties, Applications, and Research Insights

(2-Methyl-2H-indazol-5-yl)methanamine, with the CAS number 1159511-63-3, is a specialized organic compound that has garnered significant attention in pharmaceutical and biochemical research. This compound belongs to the indazole family, a class of heterocyclic structures known for their diverse biological activities. The presence of a methyl group at the 2-position and an aminomethyl substituent at the 5-position of the indazole ring imparts unique chemical and pharmacological properties to this molecule. Researchers are particularly interested in its potential as a building block for drug discovery, especially in the development of kinase inhibitors and central nervous system (CNS) therapeutics.

The growing interest in (2-Methyl-2H-indazol-5-yl)methanamine is reflected in its increasing mentions across scientific literature and patent applications. A key driver of this trend is the compound's structural similarity to other bioactive indazole derivatives, which have shown promise in targeting G-protein-coupled receptors (GPCRs) and enzyme modulation. Recent studies highlight its role in the synthesis of small-molecule probes for neurodegenerative diseases, aligning with the current focus on Alzheimer's and Parkinson's disease research. Additionally, its logP and solubility profiles make it a candidate for optimizing blood-brain barrier permeability—a critical factor in CNS drug design.

From a synthetic chemistry perspective, CAS 1159511-63-3 is often utilized as an intermediate in multistep organic synthesis. Its amine functional group allows for versatile derivatization, enabling the creation of amide or urea-linked analogs. This flexibility is particularly valuable in combinatorial chemistry and high-throughput screening platforms. Recent advancements in flow chemistry and catalysis have further streamlined its production, reducing costs and improving yields—a topic frequently searched by chemists exploring green chemistry alternatives.

The compound's relevance extends to cancer research, where indazole cores are investigated for their anti-proliferative effects. While (2-Methyl-2H-indazol-5-yl)methanamine itself is not a drug, its scaffold appears in several preclinical candidates targeting tyrosine kinases and angiogenesis pathways. This connection to precision medicine and targeted therapies aligns with trending searches in oncology, such as "small-molecule inhibitors for solid tumors" or "next-generation kinase modulators." Researchers also explore its potential in immuno-oncology, given the rising interest in immune checkpoint inhibitors.

Quality control and analytical characterization of 1159511-63-3 involve techniques like HPLC purity analysis, mass spectrometry, and NMR spectroscopy. These methods ensure batch-to-batch consistency, a critical consideration for contract research organizations (CROs) and pharmaceutical manufacturers. The compound's stability under various pH conditions and storage temperatures is another area of practical interest, often queried by laboratory professionals optimizing compound management systems.

In summary, (2-Methyl-2H-indazol-5-yl)methanamine (CAS 1159511-63-3) represents a versatile tool in modern drug discovery. Its applications span neurological disorders, oncology, and chemical biology, driven by its adaptable structure and compatibility with cutting-edge synthetic methodologies. As research into indazole pharmacophores expands, this compound is poised to remain a focal point for innovations in medicinal chemistry and therapeutic development.

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