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  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
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• 4. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

Comprehensive Overview of 1-(1-Methylindazol-5-yl)ethanone (CAS No. 1159511-24-6): Properties, Applications, and Market Insights

1-(1-Methylindazol-5-yl)ethanone (CAS No. 1159511-24-6) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural properties. This compound, belonging to the indazole derivatives family, features a methyl-substituted indazole core coupled with an acetyl functional group. Its molecular formula is C₁₀H₁₀N₂O, and it exhibits a molecular weight of 174.20 g/mol. Researchers are particularly interested in its potential as a pharmacophore in drug discovery, given its ability to interact with biological targets.

The synthesis of 1-(1-Methylindazol-5-yl)ethanone typically involves multi-step organic reactions, including Friedel-Crafts acylation and heterocyclic ring formation. Its purity and stability make it suitable for high-performance liquid chromatography (HPLC) analysis and other advanced analytical techniques. The compound's melting point and solubility profile are critical for its application in formulation studies, especially in the development of bioactive molecules.

In recent years, the demand for indazole-based compounds like 1-(1-Methylindazol-5-yl)ethanone has surged, driven by their role in kinase inhibition and cancer therapeutics. This aligns with the growing focus on targeted drug delivery systems and precision medicine, which are among the top-searched topics in pharmaceutical research. The compound's potential to modulate enzyme activity and cell signaling pathways has also made it a subject of interest in neurodegenerative disease studies.

From an industrial perspective, 1-(1-Methylindazol-5-yl)ethanone is utilized in the synthesis of high-value intermediates for APIs (Active Pharmaceutical Ingredients). Its compatibility with green chemistry principles is another highlight, as manufacturers seek sustainable alternatives to traditional synthetic methods. This trend resonates with the increasing global emphasis on environmentally friendly chemical processes, a frequently searched topic in academic and industrial circles.

The market for 1-(1-Methylindazol-5-yl)ethanone is projected to expand, particularly in regions with robust pharmaceutical R&D infrastructure, such as North America, Europe, and Asia-Pacific. Key players are investing in scalable synthesis routes to meet the rising demand from contract research organizations (CROs) and biotech startups. Additionally, the compound's relevance in computational chemistry and molecular docking studies has further amplified its commercial appeal.

For researchers exploring structure-activity relationships (SAR), 1-(1-Methylindazol-5-yl)ethanone serves as a versatile scaffold. Its electron-rich aromatic system allows for diverse functionalization, enabling the design of novel small-molecule inhibitors. This adaptability is crucial in addressing challenges like drug resistance, a hot topic in contemporary medicinal chemistry.

In summary, 1-(1-Methylindazol-5-yl)ethanone (CAS No. 1159511-24-6) represents a promising candidate for advancing drug discovery and material science. Its multifaceted applications, coupled with the industry's shift toward sustainable synthesis, position it as a compound of enduring relevance. As scientific inquiries into indazole derivatives continue to evolve, this compound is poised to play a pivotal role in shaping future innovations.

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