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• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Cinnamic acids and derivatives Coumaric acid esters

Comprehensive Overview of 2-Propenoic acid, 3-(4-hydroxyphenyl)-, 2-phenylethyl ester, (2E)- (CAS No. 115610-25-8)

2-Propenoic acid, 3-(4-hydroxyphenyl)-, 2-phenylethyl ester, (2E)-, with the CAS number 115610-25-8, is a specialized organic compound that has garnered significant attention in the fields of cosmetic chemistry, pharmaceutical research, and fragrance formulation. This ester derivative, characterized by its phenolic hydroxyl group and α,β-unsaturated carbonyl structure, exhibits unique physicochemical properties that make it valuable for various applications. Its E-configuration (2E) further enhances its stability and reactivity, which is critical for industrial use.

In recent years, the demand for natural-inspired synthetic compounds like 2-Propenoic acid, 3-(4-hydroxyphenyl)-, 2-phenylethyl ester, (2E)- has surged, driven by trends in clean beauty and sustainable skincare. Consumers and researchers alike are increasingly searching for alternatives to traditional ingredients, focusing on bioactive esters and plant-derived analogs. This compound’s structural resemblance to hydroxycinnamic acid derivatives—found in plants like cinnamon and grapes—positions it as a promising candidate for antioxidant and UV-protective formulations.

The synthesis of CAS 115610-25-8 typically involves esterification reactions between 3-(4-hydroxyphenyl)-2-propenoic acid and 2-phenylethanol, often catalyzed by green chemistry principles to minimize environmental impact. This aligns with the growing emphasis on eco-friendly production methods, a topic frequently queried in scientific databases and patent literature. Its low toxicity profile and compatibility with biodegradable matrices further enhance its appeal for cosmetic emulsifiers and controlled-release drug delivery systems.

From a functional perspective, the compound’s conjugated double bond system enables interactions with free radicals, making it a subject of interest for anti-aging research. Studies suggest potential synergies with vitamin E analogs and polyphenols, addressing common search queries like "skin barrier enhancers" and "non-irritating actives." Additionally, its aromatic phenylethyl moiety contributes to its use in perfumery, where it imparts floral and balsamic notes, catering to the niche market of fine fragrance design.

Regulatory compliance is another critical aspect for CAS 115610-25-8. While not classified as hazardous, its adoption in personal care products requires adherence to REACH and Cosmetic Ingredient Review (CIR) guidelines. This aligns with frequent searches on "EU-compliant cosmetic ingredients" and "safety assessments for ester-based compounds." Analytical techniques such as HPLC-MS and NMR spectroscopy are routinely employed to verify its purity, ensuring compliance with ISO standards.

In conclusion, 2-Propenoic acid, 3-(4-hydroxyphenyl)-, 2-phenylethyl ester, (2E)- represents a versatile compound bridging scientific innovation and market-driven applications. Its multifaceted roles—from cosmetic stabilizers to therapeutic adjuvants—underscore its relevance in contemporary research. As the industry shifts toward sustainable and multifunctional ingredients, this compound is poised to remain a focal point for both academic and commercial exploration.

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