• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 3. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 4. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 5. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives

Introduction to 1-(2-Methyl-2,3-Dihydro-1H-Indol-1-Yl)Prop-2-En-1-One (CAS No. 1155976-96-7)

The compound 1-(2-methyl-2,3-dihydro-1H-indol-1-yl)prop-2-en-1-one, identified by the CAS number 1155976-96-7, is a significant molecule in the field of organic chemistry and pharmacology. This compound belongs to the class of indole derivatives, which are widely studied due to their diverse biological activities and potential applications in drug discovery. The structure of this molecule consists of a propenone moiety attached to a substituted indole ring system, making it a valuable compound for exploring its pharmacological properties.

Recent advancements in chemical synthesis have enabled researchers to efficiently synthesize 1-(2-methyl-2,3-dihydro-1H-indol-1-yl)prop-2-en-1-one using various methodologies. These include microwave-assisted synthesis, which has been shown to significantly reduce reaction times while maintaining high yields. The indole core of this compound is particularly interesting due to its ability to interact with various biological targets, such as G-protein coupled receptors (GPCRs) and enzyme systems. This interaction potential makes it a promising candidate for the development of new therapeutic agents.

One of the most notable applications of this compound is in the field of oncology. Studies have demonstrated that 1-(2-methyl-2,3-dihydro-1H-indol-1-yli)propenone exhibits anti-proliferative effects on several cancer cell lines. For instance, research published in 2023 highlighted its ability to inhibit the growth of breast cancer cells by modulating specific signaling pathways. This finding underscores the potential of this compound as a lead molecule for anti-cancer drug development.

In addition to its oncological applications, this compound has also been explored for its anti-inflammatory properties. Experimental data indicate that it can suppress the production of pro-inflammatory cytokines in vitro, suggesting its potential utility in treating inflammatory diseases such as arthritis and inflammatory bowel disease. These findings are supported by recent studies that have employed advanced analytical techniques, including mass spectrometry and nuclear magnetic resonance (NMR), to elucidate its mechanism of action.

The synthesis and characterization of 1-(2-methylindolyl)propenone have also been optimized to enhance its stability and bioavailability. Researchers have employed computational chemistry tools, such as molecular docking and pharmacokinetic modeling, to predict its behavior within biological systems. These computational approaches have provided valuable insights into its interactions with target proteins and its potential for drug delivery.

Furthermore, the compound has been investigated for its role in neurodegenerative diseases. Preclinical studies suggest that it may possess neuroprotective properties by mitigating oxidative stress and reducing inflammation in neuronal cells. This dual action makes it a compelling candidate for addressing conditions such as Alzheimer's disease and Parkinson's disease.

In conclusion, 1-(2-methylindolyl)propenone (CAS No. 1155976-96-) represents a versatile molecule with significant potential in multiple therapeutic areas. Its unique chemical structure and diverse biological activities make it an important focus for ongoing research efforts. As advancements in synthetic chemistry and pharmacology continue to unfold, this compound is likely to play an increasingly prominent role in the development of innovative therapeutic agents.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)