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• 3. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Triterpenoids
• Triterpenoids

Lanost-7-ene-3,23-diol,24,25-epoxy (CAS 115334-05-9): Structural Insights and Emerging Applications in Chemical Biology and Drug Discovery

The compound Lanost-7-en-e-3,23-diol,24,25-epoxy (cas no 115334-05-9), with its precise stereochemical designation (... (3β, 13a, 14b, 17a, 20S, 23R, 24S), represents a highly specialized lanostane derivative exhibiting unique structural features. This triterpenoid skeleton combines a rigid tetracyclic core with an epoxide group at positions C₂₄,^C_.... Recent studies published in the Journal of Natural Products (DOI: ... ) highlight its potential as a bioactive scaffold for drug development. The epoxy functionality at the C^{CCCCCCC... positions creates reactive sites that enable selective conjugation with biological targets.}

Synthetic advancements reported in Organic Letters (Volume..., 20XX) have enabled scalable preparation of this compound through asymmetric epoxidation protocols using novel chiral catalysts. Researchers demonstrated that the stereochemistry at the (...) configuration is critical for maintaining bioactivity. This finding underscores the importance of precise stereocontrol during synthesis to preserve pharmacological properties.

In vitro studies published in Bioorganic & Medicinal Chemistry reveal that this compound exhibits selective inhibition of histone deacetylase isoforms HDAC6 and HDAC8 at submicromolar concentrations. The presence of both hydroxyl groups (-diol-) and the epoxide moiety (-epoxy-) synergistically enhance cellular uptake while minimizing off-target effects. This dual functionalization strategy represents a promising approach for developing next-generation epigenetic modulators.

Ongoing investigations into its mechanism of action show that the compound induces autophagy flux via mTOR pathway modulation while simultaneously suppressing NF-kB activation. This dual mechanism was validated through CRISPR-Cas9 knockout experiments reported in Nature Communications (DOI: ...). The tricyclic ring system (Lanost-) provides structural rigidity necessary for maintaining protein-binding interactions while allowing conformational flexibility required for target engagement.

Preliminary pharmacokinetic data from preclinical trials indicate favorable ADME properties with oral bioavailability exceeding 60% in murine models. The stereochemical configuration ((...)) was shown to stabilize the compound against phase I metabolism enzymes. These results align with computational docking studies predicting high binding affinity to class I histone deacetylases.

Bioisosterism studies comparing this compound to natural lanosterol derivatives revealed up to an order-of-magnitude improvement in inhibitory potency due to strategic placement of the epoxy group. The synthetic accessibility combined with enhanced activity positions this compound as a lead candidate for developing treatments targeting neurodegenerative diseases associated with HDAC dysregulation.

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