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  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 2. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles

Introduction to 3-(3-Cyanophenyl)-1,2-oxazole-5-carboxylic Acid (CAS No. 1152531-77-5)

3-(3-Cyanophenyl)-1,2-oxazole-5-carboxylic acid is a significant compound in the field of pharmaceutical chemistry, characterized by its unique molecular structure and potential applications. This compound, identified by the CAS number 1152531-77-5, has garnered attention due to its role in the synthesis of various pharmacologically active molecules. The presence of a cyano group and an oxazole ring system imparts distinct chemical properties that make it a valuable intermediate in drug development.

The compound's structure consists of a benzene ring substituted with a cyano group at the 3-position, linked to an oxazole core. The oxazole ring, a five-membered heterocycle containing one oxygen and one nitrogen atom, is known for its stability and reactivity, making it a versatile scaffold in medicinal chemistry. The carboxylic acid functionality at the 5-position of the oxazole ring further enhances its utility as a building block for more complex molecules.

In recent years, there has been growing interest in oxazole derivatives due to their broad spectrum of biological activities. These derivatives have been explored for their potential in treating various diseases, including infectious disorders and inflammatory conditions. The specific arrangement of functional groups in 3-(3-cyanophenyl)-1,2-oxazole-5-carboxylic acid makes it a promising candidate for further investigation in this context.

One of the most compelling aspects of this compound is its role in the synthesis of bioactive molecules. Researchers have utilized it as an intermediate to develop novel inhibitors targeting enzymes involved in metabolic pathways. For instance, studies have shown that derivatives of this compound exhibit inhibitory effects on certain kinases, which are critical in regulating cell growth and division. This has opened up avenues for its use in developing treatments for cancers and other proliferative diseases.

The cyano group in the molecule contributes to its reactivity, allowing for further functionalization through various chemical transformations. This flexibility is particularly valuable in drug discovery pipelines, where compounds often require multiple modifications to achieve desired pharmacological properties. The oxazole ring's ability to participate in hydrogen bonding and its stability under various conditions also make it an attractive feature for medicinal chemists.

Recent advancements in computational chemistry have enabled more efficient screening of compounds like 3-(3-cyanophenyl)-1,2-oxazole-5-carboxylic acid for potential biological activity. High-throughput virtual screening (HTVS) techniques have been employed to identify derivatives with enhanced binding affinity to target proteins. This approach has significantly accelerated the drug discovery process, allowing researchers to focus on the most promising candidates.

The synthesis of 3-(3-cyanophenyl)-1,2-oxazole-5-carboxylic acid involves multi-step organic reactions that require careful optimization to ensure high yield and purity. Common synthetic routes include cyclization reactions followed by functional group transformations. The use of advanced catalytic systems has improved the efficiency of these processes, reducing both reaction times and waste generation.

In conclusion, 3-(3-cyanophenyl)-1,2-oxazole-5-carboxylic acid (CAS No. 1152531-77-5) is a versatile compound with significant potential in pharmaceutical research. Its unique structural features make it a valuable intermediate for developing novel therapeutic agents. As research continues to uncover new applications for oxazole derivatives, this compound is likely to play an increasingly important role in drug discovery and development.

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