Cas no 1152197-23-3 (8-pCPT-2’-O-Me-cAMP-AM)
8-pCPT-2’-O-Me-cAMP-AM is a membrane-permeable, hydrolysis-resistant cAMP analog designed for precise modulation of intracellular signaling pathways. The 2’-O-methyl modification enhances stability against phosphodiesterase degradation, while the p-chlorophenylthio (pCPT) group improves cell permeability and potency. The acetoxymethyl (AM) ester facilitates cellular uptake, where esterases cleave it to release the active compound. This analog selectively activates Epac (Exchange protein directly activated by cAMP) over PKA, making it a valuable tool for studying cAMP-mediated processes such as cell proliferation, differentiation, and secretion. Its resistance to enzymatic breakdown ensures prolonged activity, enabling robust and sustained experimental outcomes in cellular assays. Suitable for research in neuroscience, cardiology, and endocrinology.
8-pCPT-2’-O-Me-cAMP-AM structure
Product Name:8-pCPT-2’-O-Me-cAMP-AM
CAS No:1152197-23-3
MF:C20H21ClN5O8PS
MW:557.901202917099
CID:1073998
PubChem ID:90488978
Update Time:2025-10-05
8-pCPT-2’-O-Me-cAMP-AM Chemical and Physical Properties
Names and Identifiers
-
- [13C6]-8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-(acetyloxy)methyl)-cyclic monophosphate
- 8-pCPT-2-O-Me-cAMP-AM
- 8-CPT-AM
- 007-AM
- 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester
- 1152197-23-3
- CS-0028851
- (((4aR,6R,7R,7aR)-6-(6-amino-8-((4-chlorophenyl)thio)-9H-purin-9-yl)-7-methoxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl acetate
- HY-107544
- {[(4aR,6R,7R,7aR)-6-{6-Amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxy-2-oxo-hexahydro-2
- {[(4aR,6R,7R,7aR)-6-{6-Amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl]oxy}methyl acetate
- PD079765
- [(4aR,6R,7R,7aR)-6-[6-amino-8-(4-chlorophenyl)sulfanylpurin-9-yl]-7-methoxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl]oxymethyl acetate
- AKOS024458377
- 8-pCPT-2'-O-Me-cAMP-AM
- DA-59751
- GLXC-20874
- E-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl]oxy}methyl acetate
- 8-pCPT-2’-O-Me-cAMP-AM
-
- Inchi： 1S/C20H21ClN5O8PS/c1-10(27)30-9-32-35(28)31-7-13-15(34-35)16(29-2)19(33-13)26-18-14(17(22)23-8-24-18)25-20(26)36-12-5-3-11(21)4-6-12/h3-6,8,13,15-16,19H,7,9H2,1-2H3,(H2,22,23,24)/t13-,15-,16-,19-,35?/m1/s1
- InChI Key： FZMWUFYPEVDWPA-SILPBKOMSA-N
- SMILES： ClC1C=CC(=CC=1)SC1=NC2C(N)=NC=NC=2N1[C@H]1[C@@H]([C@H]2[C@@H](COP(=O)(OCOC(C)=O)O2)O1)OC
Computed Properties
- Exact Mass: 557.0536985g/mol
- Monoisotopic Mass: 557.0536985g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 13
- Heavy Atom Count: 36
- Rotatable Bond Count: 8
- Complexity: 844
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 4
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 184
- XLogP3: 1.5
8-pCPT-2’-O-Me-cAMP-AM Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | C781488-25?g |
8-pCPT-2’-O-Me-cAMP-AM |
1152197-23-3 | 25?g |
$ 170.00 | 2022-01-10 | ||
| TRC | C781488-50?g |
8-pCPT-2’-O-Me-cAMP-AM |
1152197-23-3 | 50?g |
$ 315.00 | 2022-01-10 | ||
| TRC | C781488-100?g |
8-pCPT-2’-O-Me-cAMP-AM |
1152197-23-3 | 100μg |
$ 545.00 | 2022-01-10 | ||
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci16640-100ug |
8-pCPT-2-O-Me-cAMP-AM |
1152197-23-3 | 98% | 100ug |
￥1599.00 | 2023-09-09 | |
| TRC | C781488-25μg |
8-pCPT-2’-O-Me-cAMP-AM |
1152197-23-3 | 25μg |
$ 170.00 | 2022-06-02 | ||
| TRC | C781488-50μg |
8-pCPT-2’-O-Me-cAMP-AM |
1152197-23-3 | 50μg |
$ 315.00 | 2022-06-02 | ||
| TRC | C781488-100μg |
8-pCPT-2’-O-Me-cAMP-AM |
1152197-23-3 | 100μg |
$ 545.00 | 2022-06-02 |
8-pCPT-2’-O-Me-cAMP-AM Related Literature
-
Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
-
Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
-
Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
-
Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
-
Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
Related Categories
- Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides 3',5'-cyclic purine nucleotides
- Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Cyclic purine nucleotides 3',5'-cyclic purine nucleotides
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