Cas no 114873-10-8 (Boc-D-2-Fluorophenylalanine)
Boc-D-2-Fluorophenylalanine Chemical and Physical Properties
Names and Identifiers
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- (R)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluorophenyl)propanoic acid
- BOC-2-fluoro-D-phenylalanine
- BOC-D-Phe(2-F)-OH
- tert-Butoxycarbonyl-D-2-fluorophenylalanine
- (R)-N-BOC-2-Fluorophenylalanine
- Boc-D-2-Fluorophe
- Boc-D-2-Fluorophenylalanine
- BOC-D-PHE(O-F)-OH
- BOC-2-FLUORO-D-PHE
- RARECHEM BK PT 0023
- BOC-O-FLUORO-D-PHE-OH
- Boc-D-2-Fluoro-phe-OH
- PS-12132
- MFCD00672521
- N-alpha-t-Butyloxycarbonyl-D-2-fluorophenylalanine (Boc-D-Phe(2-F)-OH)
- N10787
- N-tert-Butoxycarbonyl-D-2-Fluoro Phenylalanine
- J-003147
- AKOS015994903
- SCHEMBL270318
- (R)-2-(tert-butoxycarbonylamino)-3-(2-fluorophenyl)propanoic acid
- (2R)-3-(2-fluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
- 114873-10-8
- (R)-2-TERT-BUTOXYCARBONYLAMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
- DTXSID60427299
- AM83331
- NTWUXBKUDXGMHV-LLVKDONJSA-N
- Boc-D-Phe(2-F)-OH, >=98.0% (TLC)
- CS-W012252
- EN300-2010708
- (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-(2-fluorophenyl)propanoic acid
- Boc-L-phe(2-F)-OH
- N-(tert-butoxycarbonyl)-2-fluoro-D-phenylalanine
- (R)-2-tert-butoxycarbonylamino-3-(2-fluorophenyl)propionic acid
- AC-5823
- D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-2-fluoro-
- CHEMBL5305671
- (2R)-2-[(tert-butoxycarbonyl)amino]-3-(2-fluorophenyl)propanoic acid
-
- MDL： MFCD00672521
- Inchi： 1S/C14H18FNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-6-4-5-7-10(9)15/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m1/s1
- InChI Key： NTWUXBKUDXGMHV-LLVKDONJSA-N
- SMILES： FC1C=CC=CC=1C[C@H](C(=O)O)NC(=O)OC(C)(C)C
Computed Properties
- Exact Mass: 283.12200
- Monoisotopic Mass: 283.122
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 20
- Rotatable Bond Count: 7
- Complexity: 354
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 75.6A^2
- XLogP3: 2.6
Experimental Properties
- Color/Form: No data available
- Density: 1.1918 (estimate)
- Melting Point: 94 oC
- Boiling Point: 308.1°Cat760mmHg
- Flash Point: 140.1°C
- PSA: 75.63000
- LogP: 2.73700
- Specific Rotation: -10 o (c=1,EtOAc)
Boc-D-2-Fluorophenylalanine Security Information
- Signal Word：warning
- Hazard Statement： Irritant/Keep Cold
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - WGK Germany：3
- Hazard Category Code： R36/37/38: irritating to eyes, respiratory tract and skin
- Safety Instruction： S24/25
-
Hazardous Material Identification：
- Safety Term：S24/25
- Risk Phrases：R36/37/38
- Storage Condition：Keep cold
Boc-D-2-Fluorophenylalanine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM220316-10g |
(R)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluorophenyl)propanoic acid |
114873-10-8 | 95% | 10g |
$168 | 2021-06-09 | |
| Chemenu | CM220316-25g |
(R)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluorophenyl)propanoic acid |
114873-10-8 | 95% | 25g |
$365 | 2021-06-09 | |
| Chemenu | CM220316-10g |
(R)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluorophenyl)propanoic acid |
114873-10-8 | 95% | 10g |
$168 | 2023-02-19 | |
| Chemenu | CM220316-25g |
(R)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluorophenyl)propanoic acid |
114873-10-8 | 95% | 25g |
$365 | 2023-02-19 | |
| Apollo Scientific | PC5023-5g |
2-Fluoro-D-phenylalanine, N-BOC protected |
114873-10-8 | 97% | 5g |
￡85.00 | 2025-02-21 | |
| Apollo Scientific | PC5023-25g |
2-Fluoro-D-phenylalanine, N-BOC protected |
114873-10-8 | 97% | 25g |
￡216.00 | 2025-02-21 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | B832735-1g |
Boc-D-Phe(2-F)-OH |
114873-10-8 | ≥98% | 1g |
￥196.20 | 2022-09-02 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | B832735-5g |
Boc-D-Phe(2-F)-OH |
114873-10-8 | ≥98% | 5g |
￥680.40 | 2022-09-02 | |
| AAPPTec | UBF220-5g |
Boc-D-Phe(2-F)-OH |
114873-10-8 | 5g |
$95.00 | 2024-07-20 | ||
| AAPPTec | UBF220-25g |
Boc-D-Phe(2-F)-OH |
114873-10-8 | 25g |
$395.00 | 2024-07-20 |
Boc-D-2-Fluorophenylalanine Related Literature
-
Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
-
Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
-
Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
-
Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
-
Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
Additional information on Boc-D-2-Fluorophenylalanine
Boc-D-2-Fluorophenylalanine: A Comprehensive Overview
The compound with CAS No. 114873-10-8, known as Boc-D-2-Fluorophenylalanine, is a significant molecule in the field of organic chemistry and biochemistry. This compound is a derivative of phenylalanine, a naturally occurring amino acid, with a fluorine atom substituted at the 2-position of the benzene ring. The presence of the tert-butoxycarbonyl (Boc) group further modifies its structure, making it a valuable intermediate in peptide synthesis and other chemical reactions.
Boc-D-2-Fluorophenylalanine has garnered attention due to its unique properties and potential applications in drug discovery and biotechnology. Recent studies have highlighted its role in the development of novel therapeutic agents, particularly in the context of fluorinated amino acids. Fluorination is a common strategy in drug design to enhance pharmacokinetic properties such as stability, bioavailability, and metabolic resistance. The 2-fluoro substitution in this compound provides a promising platform for exploring these attributes.
The synthesis of Boc-D-2-Fluorophenylalanine involves a multi-step process that combines principles from organic synthesis and stereochemistry. The starting material is typically L-phenylalanine, which undergoes several transformations to introduce the fluorine atom and the Boc group. Researchers have optimized these steps to achieve high yields and enantiomeric purity, ensuring that the compound meets the stringent requirements of modern pharmaceutical research.
One of the most exciting developments involving Boc-D-2-Fluorophenylalanine is its application in peptide synthesis. The Boc group serves as an excellent protecting group for the amino terminus, allowing for precise control during peptide assembly. This has enabled chemists to construct complex peptide sequences with high fidelity, paving the way for the creation of bioactive peptides with potential therapeutic applications.
Recent advancements in analytical techniques have also enhanced our understanding of Boc-D-2-Fluorophenylalanine's structural and electronic properties. For instance, nuclear magnetic resonance (NMR) spectroscopy has provided insights into its conformational flexibility, while mass spectrometry has confirmed its molecular integrity. These studies are crucial for validating the compound's suitability in various chemical and biological assays.
In terms of biological activity, Boc-D-2-Fluorophenylalanine has shown promise in modulating enzyme activity and cellular signaling pathways. Preclinical studies suggest that it may possess anti-inflammatory or neuroprotective effects, although further research is needed to confirm these findings. Its fluorinated nature could also confer resistance to enzymatic degradation, making it an attractive candidate for long-lasting drug delivery systems.
The demand for Boc-D-2-Fluorophenylalanine has been driven by its versatility across multiple disciplines. Chemists value it for its reactivity in coupling reactions, while biologists appreciate its role as a building block for constructing bioactive molecules. Its inclusion in high-throughput screening libraries has further expanded its utility in drug discovery pipelines.
From an environmental perspective, researchers have investigated the degradation pathways of Boc-D-2-Fluorophenylalanine under various conditions. Understanding its fate in natural systems is essential for assessing its potential impact on ecosystems and ensuring sustainable practices in chemical manufacturing.
In conclusion, Boc-D-2-Fluorophenylalanine stands out as a versatile and innovative compound with wide-ranging applications in chemistry and biology. Its unique structure, combined with cutting-edge research findings, positions it as a key player in advancing drug development and chemical synthesis technologies.
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