• 1. Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors
  Baijiao An,Shun Zhang,Jun Yan,Ling Huang,Xingshu Li Org. Biomol. Chem. 2017 15 852
• 2. The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors
  Shun Zhang,Baijiao An,Jun Yan,Ling Huang,Xingshu Li RSC Adv. 2016 6 88453

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols

Introduction to 4-METHOXY-3-METHYLBENZYL ALCOHOL (CAS No. 114787-91-6)

4-METHOXY-3-METHYLBENZYL ALCOHOL, identified by the Chemical Abstracts Service Number (CAS No.) 114787-91-6, is a versatile organic compound that has garnered significant attention in the field of pharmaceutical chemistry and chemical biology. This compound, featuring a benzyl alcohol backbone with methoxy and methyl substituents, exhibits unique structural and functional properties that make it a valuable intermediate in synthetic chemistry and a potential candidate for various biological applications.

The molecular structure of 4-METHOXY-3-METHYLBENZYL ALCOHOL consists of a benzene ring substituted at the 4-position with a methoxy group (-OCH?) and at the 3-position with a methyl group (-CH?). This arrangement imparts specific electronic and steric characteristics to the molecule, influencing its reactivity and interactions with biological targets. The presence of both electron-donating methoxy and methyl groups enhances the compound's solubility in both polar and non-polar solvents, making it highly adaptable for different chemical reactions and formulations.

In recent years, 4-METHOXY-3-METHYLBENZYL ALCOHOL has been explored in the development of novel pharmaceutical agents. Its structural motif is reminiscent of many bioactive molecules, particularly those targeting neurological and inflammatory pathways. The benzyl alcohol moiety, known for its ability to enhance membrane permeability and stabilize protein structures, has been utilized in drug delivery systems. Additionally, the methoxy and methyl groups can serve as points for further functionalization, allowing chemists to tailor the compound for specific biological activities.

One of the most promising areas of research involving 4-METHOXY-3-METHYLBENZYL ALCOHOL is its potential application as an intermediate in the synthesis of kinase inhibitors. Kinases are enzymes that play critical roles in cell signaling pathways, and their dysregulation is implicated in numerous diseases, including cancer. By modifying the structure of 4-METHOXY-3-METHYLBENZYL ALCOHOL, researchers have been able to develop derivatives that exhibit potent inhibitory effects on specific kinases. These derivatives are being investigated in preclinical studies to assess their efficacy and safety profiles.

Another significant application of 4-METHOXY-3-METHYLBENZYL ALCOHOL is in the field of natural product synthesis. Many secondary metabolites isolated from plants and microorganisms contain complex aromatic structures similar to that of 4-METHOXY-3-METHYLBENZYL ALCOHOL. The compound serves as a key building block in the total synthesis of these natural products, enabling chemists to produce molecules with high enantiomeric purity. This approach not only aids in understanding the biosynthetic pathways of these compounds but also provides access to novel therapeutic agents.

The role of 4-METHOXY-3-METHYLBENZYL ALCOHOL in material science is also noteworthy. Its ability to form stable complexes with metal ions has been exploited in the development of coordination polymers and metal-organic frameworks (MOFs). These materials have applications ranging from gas storage and separation to catalysis and sensing. The methoxy and methyl groups can act as ligands, coordinating with metal centers to create porous structures with tailored properties.

In conclusion, 4-METHOXY-3-METHYLBENZYL ALCOHOL (CAS No. 114787-91-6) is a multifaceted compound with broad utility across multiple scientific disciplines. Its unique structural features make it an invaluable tool in pharmaceutical research, natural product synthesis, and material science. As ongoing research continues to uncover new applications for this compound, its importance is likely to grow further, solidifying its place as a cornerstone molecule in modern chemistry.

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