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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

Introduction to 1-[(pyridin-4-yl)methyl]-1H-pyrazol-3-amine (CAS No. 1142952-13-3)

1-[(pyridin-4-yl)methyl]-1H-pyrazol-3-amine, also known by its CAS registry number 1142952-13-3, is a versatile and intriguing compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound is a derivative of pyrazole, a five-membered aromatic heterocycle, which is widely recognized for its unique electronic properties and biological activity. The presence of the pyridine ring in its structure further enhances its functional versatility, making it a valuable molecule for both academic research and industrial applications.

The synthesis of 1-(pyridin-4-ylmethyl)-1H-pyrazol-3-amines has been extensively studied, with researchers exploring various methodologies to optimize the reaction conditions and scalability. Recent advancements in catalytic asymmetric synthesis have enabled the preparation of enantiomerically enriched derivatives, which are particularly valuable for drug discovery and development. The compound's ability to undergo further functionalization has also been leveraged to create libraries of structurally diverse analogs, facilitating high-throughput screening for potential therapeutic agents.

One of the most notable applications of CAS No. 1142952-13-3 lies in its role as a building block in medicinal chemistry. Its pyrazole core is known to exhibit significant bioactivity, particularly in the context of kinase inhibition and anti-inflammatory effects. Recent studies have demonstrated that this compound can serve as a scaffold for designing potent inhibitors of key enzymes involved in cancer progression and neurodegenerative diseases. For instance, researchers have reported that certain derivatives exhibit remarkable selectivity towards protein kinase C (PKC), a family of enzymes implicated in various pathological conditions.

In addition to its pharmacological relevance, 1-(pyridin-4-yrmethyl)-pyrazolamine has also found applications in materials science. Its ability to coordinate with metal ions has made it a promising candidate for constructing metallo-supramolecular architectures. Recent investigations have highlighted its potential as a ligand in the synthesis of coordination polymers and metal organic frameworks (MOFs), which are widely used in gas storage, catalysis, and sensing technologies.

The structural flexibility of CAS No. 1142952-13-3 also lends itself well to click chemistry approaches. Researchers have exploited its reactivity to develop efficient routes for constructing complex molecular frameworks. For example, copper-catalyzed azide–alkyne cycloaddition (CuAAC) reactions have been employed to generate novel heterocyclic compounds with enhanced stability and bioavailability.

From an environmental perspective, the compound's degradation pathways and ecotoxicological effects have been studied to ensure its safe handling and disposal. Recent eco-toxicity assessments indicate that under controlled conditions, pyrazole-based derivatives exhibit low toxicity towards aquatic organisms, making them suitable for use in green chemical processes.

In conclusion, CAS No. 1142952 - 3 - amine stands out as a multifaceted compound with vast potential across diverse scientific domains. Its unique chemical properties, coupled with recent advancements in synthetic methodologies and application-oriented research, position it as a key player in the development of innovative solutions in medicine, materials science, and beyond.

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