• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 5. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400

4-Bromo-2-propoxypyridine (CAS 1142194-49-7): A Versatile Building Block in Modern Organic Synthesis

4-Bromo-2-propoxypyridine (CAS 1142194-49-7) is a specialized halogenated pyridine derivative that has gained significant attention in pharmaceutical and material science research. This brominated heterocyclic compound serves as a crucial intermediate in the synthesis of various bioactive molecules and functional materials. With its unique propoxy substitution pattern and reactive bromine atom at the 4-position, this compound offers exceptional versatility in cross-coupling reactions and molecular transformations.

The growing demand for 4-Bromo-2-propoxypyridine CAS 1142194-49-7 reflects current trends in drug discovery, where researchers are increasingly focusing on pyridine-based scaffolds for developing new therapeutic agents. Recent studies highlight its potential in creating kinase inhibitors and CNS-active compounds, addressing the pharmaceutical industry's need for novel treatments in neurology and oncology. The compound's electronic properties and steric characteristics make it particularly valuable in designing molecules with improved bioavailability and target specificity.

From a synthetic chemistry perspective, 4-Bromo-2-propoxypyridine 1142194-49-7 demonstrates excellent reactivity in palladium-catalyzed couplings, including Suzuki-Miyaura and Buchwald-Hartwig reactions. This aligns with the current industry emphasis on green chemistry and atom-efficient transformations. The propoxy group at the 2-position provides both steric protection and electronic modulation, allowing for selective functionalization at the brominated position while maintaining the integrity of the pyridine core.

The material science applications of 4-Bromo-2-propoxypyridine CAS no 1142194-49-7 are equally noteworthy. Researchers are exploring its use in constructing organic electronic materials, particularly in the development of OLED components and conductive polymers. The compound's ability to serve as a π-conjugated building block makes it valuable for creating advanced materials with tunable optoelectronic properties, responding to the growing demand for energy-efficient display technologies.

Quality control and analytical characterization of 4-Bromo-2-propoxypyridine 1142194-49-7 typically involve advanced techniques such as HPLC purity analysis, mass spectrometry, and NMR spectroscopy. These methods ensure the compound meets the stringent requirements of pharmaceutical and material science applications. Current market trends show increasing requests for high-purity 4-Bromo-2-propoxypyridine with comprehensive analytical documentation, reflecting the compound's expanding role in regulated research environments.

Storage and handling recommendations for 4-Bromo-2-propoxypyridine CAS 1142194-49-7 emphasize protection from moisture and light, typically suggesting storage under inert atmosphere at controlled temperatures. These precautions maintain the compound's stability and reactivity, crucial for its performance in sensitive synthetic applications. The development of improved packaging solutions for air-sensitive pyridine derivatives represents an active area of innovation in fine chemical supply chains.

The synthesis of 4-Bromo-2-propoxypyridine typically involves selective bromination of 2-propoxypyridine precursors, with modern protocols focusing on regioselective halogenation methods that minimize byproduct formation. Recent process optimization efforts have addressed key challenges in scaling up production while maintaining high yields and purity standards, responding to the compound's growing commercial importance.

In the context of intellectual property, 4-Bromo-2-propoxypyridine 1142194-49-7 appears in numerous patent applications as a key intermediate for pharmaceutical candidates. This highlights its strategic value in drug discovery pipelines and the importance of reliable supply chains for research and development activities. The compound's structural features make it particularly valuable for creating bioisosteres and metabolic stability enhancers in medicinal chemistry programs.

Environmental and safety considerations for 4-Bromo-2-propoxypyridine CAS no 1142194-49-7 follow standard laboratory chemical protocols, with particular attention to proper ventilation and personal protective equipment during handling. The development of greener synthetic routes for such halogenated intermediates remains an active research area, aligning with broader sustainability initiatives in the chemical industry.

Market analysis indicates steady growth in demand for 4-Bromo-2-propoxypyridine, particularly from contract research organizations and academic institutions engaged in cutting-edge pharmaceutical development. The compound's price stability and availability from multiple qualified suppliers contribute to its popularity as a research chemical, with projections suggesting continued interest as new applications emerge in both life sciences and materials research.

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