• 1. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 4. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 5. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

Comprehensive Guide to 4-Bromo-2-cyclobutylpyridine (CAS No. 1142194-11-3): Properties, Applications, and Industry Insights

4-Bromo-2-cyclobutylpyridine (CAS No. 1142194-11-3) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This brominated pyridine derivative, featuring a cyclobutyl substituent, serves as a versatile building block for synthesizing complex molecules. Its unique structural attributes, including the electron-withdrawing bromo group and the strained cyclobutyl ring, make it invaluable for designing bioactive compounds with tailored properties.

In recent years, the demand for 4-Bromo-2-cyclobutylpyridine has surged due to its role in drug discovery and material science. Researchers leverage its reactivity in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, to construct aryl-aryl bonds—a critical step in developing kinase inhibitors and other therapeutic agents. The compound’s CAS No. 1142194-11-3 is frequently searched in databases like SciFinder and Reaxys, reflecting its industrial relevance.

From an SEO perspective, queries like "4-Bromo-2-cyclobutylpyridine synthesis" or "CAS 1142194-11-3 suppliers" dominate search trends, aligning with the growing interest in custom synthesis and high-purity intermediates. Environmental concerns have also spurred innovations in green chemistry approaches for its production, minimizing hazardous byproducts. This aligns with the broader industry shift toward sustainable chemical manufacturing.

The compound’s physicochemical properties—such as its molecular weight (212.08 g/mol) and lipophilicity (LogP ~2.5)—are optimized for bioavailability, a key focus in medicinal chemistry. Its pyridine core enables hydrogen bonding, while the bromine atom facilitates further functionalization, making it a multifunctional scaffold. These traits are particularly valuable in developing central nervous system (CNS) drugs, where molecular rigidity and solubility are critical.

Emerging applications of 4-Bromo-2-cyclobutylpyridine extend to catalysis and organic electronics. For instance, its derivatives are explored as ligands in transition-metal catalysis to enhance reaction efficiency. Additionally, its conjugated system shows promise in OLED materials, addressing the demand for energy-efficient displays. Such interdisciplinary relevance underscores its importance beyond traditional chemistry sectors.

Quality control protocols for CAS No. 1142194-11-3 emphasize HPLC purity (>98%) and NMR validation, ensuring consistency for regulatory compliance. Suppliers often highlight these specifications to meet the stringent requirements of GMP-certified facilities. As the fine chemicals market expands, transparency in supply chain documentation becomes a competitive differentiator.

In summary, 4-Bromo-2-cyclobutylpyridine exemplifies the convergence of synthetic innovation and industrial demand. Its adaptability across life sciences and advanced materials positions it as a cornerstone in modern chemistry. Future research may explore its potential in bioconjugation or proteolysis-targeting chimeras (PROTACs), further solidifying its role in next-generation therapeutics.

• 1395492-74-6(4-bromo-2-(1-methylcyclobutyl)pyridine)
• 1643564-88-8(4-Bromo-2-(iso-butyl)pyridine-d12)
• 1159815-16-3(5-Bromo-2-cyclobutylpyridine)
• 1563532-13-7(4-Bromo-2-isobutylpyridine)
• 1823567-27-6(Pyridine, 4-bromo-2-butyl-)
• 1163707-47-8(4-Bromo-2-(1-methylcyclopropyl)pyridine)
• 1379368-18-9(4-Bromo-2,6-dicyclopropylpyridine)
• 1086381-30-7(4-Bromo-2-tert-butylpyridine)
• 908267-63-0(4-bromo-2-(propan-2-yl)pyridine)
• 1086381-28-3(4-Bromo-2-cyclopropylpyridine)