Cas no 114214-73-2 (Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate)

Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate is a versatile chiral building block widely used in organic synthesis and pharmaceutical research. Its key structural features include a Boc-protected amine group and a hydroxymethyl substituent on the pyrrolidine ring, offering dual functionality for further derivatization. The tert-butyloxycarbonyl (Boc) group ensures stability during synthetic transformations while allowing selective deprotection under mild acidic conditions. The compound’s rigid pyrrolidine scaffold and stereogenic centers make it valuable for designing bioactive molecules, particularly in medicinal chemistry applications. Its high purity and well-defined stereochemistry facilitate precise incorporation into complex targets, such as protease inhibitors or peptidomimetics. The hydroxyl group provides an additional handle for conjugation or structural diversification.

Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate structure

114214-73-2 structure

Product Name:Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate

CAS No:114214-73-2

MF:C₁₀H₂₀N₂O₃

MW:216.277402877808

MDL:MFCD18917057

CID:1088149

PubChem ID:20067150

Update Time:2025-05-21

Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate Chemical and Physical Properties

Names and Identifiers

- tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate
- 1-Boc-3-(aminomethyl)-3-hydroxypyrrolidine
- TERT-BUTYL 3-(AMINOMETHYL)-3-HYDROXY-1-PYRROLIDINECARBOXYLATE
- 1-Boc-3-(aMinoMethyl)-3-h...
- 1-Pyrrolidinecarboxylic acid, 3-(aminomethyl)-3-hydroxy-, 1,1-dimethylethyl ester
- PB31931
- ST1271441
- AM20080087
- Z1505708930
- EN300-260862
- SCHEMBL9773945
- AS-34553
- MFCD18917057
- DB-201617
- A894245
- 114214-73-2
- CS-0048376
- tert-butyl3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate
- tert-Butyl 3-(aminomethyl)-3-hydroxy-pyrrolidine-1-carboxylate
- AKOS022185642
- Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate
- MDL： MFCD18917057
- Inchi： 1S/C10H20N2O3/c1-9(2,3)15-8(13)12-5-4-10(14,6-11)7-12/h14H,4-7,11H2,1-3H3
- InChI Key： MCGDVVXFTUKWNU-UHFFFAOYSA-N
- SMILES： OC1(CN)CN(C(=O)OC(C)(C)C)CC1

Computed Properties

Exact Mass: 216.14739250g/mol
Monoisotopic Mass: 216.14739250g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 15
Rotatable Bond Count: 3
Complexity: 250
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 75.8
XLogP3: -0.5

Experimental Properties

Color/Form: NA
Density: 1.2±0.1 g/cm3
Boiling Point: 323.9±27.0 °C at 760 mmHg
Flash Point: 120.7±13.5 °C

Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate Security Information

Signal Word：warning
Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
Warning Statement： P264+P280+P305+P351+P338+P337+P313
Safety Instruction： H303+H313+H333
Storage Condition：Storage at -4 ℃ (6-12weeks), long storage period at -20 ℃ (1-2years), transport at 0 ℃

Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Alichem	A109006658-1g	tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate	114214-73-2	95%	1g	$356.43	2023-09-04
Alichem	A109006658-5g	tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate	114214-73-2	95%	5g	$999.60	2023-09-04
TRC	B630148-50mg	1-Boc-3-(aminomethyl)-3-hydroxypyrrolidine	114214-73-2		50mg	$ 50.00	2022-06-07
TRC	B630148-100mg	1-Boc-3-(aminomethyl)-3-hydroxypyrrolidine	114214-73-2		100mg	$ 70.00	2022-06-07
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ChemScence	CS-0048376-250mg	tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate	114214-73-2		250mg	$75.0	2022-04-28
ChemScence	CS-0048376-1g	tert-Butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate	114214-73-2		1g	$150.0	2022-04-28
Chemenu	CM105787-1g	tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate	114214-73-2	97%	1g	$251	2021-08-06
Chemenu	CM105787-5g	tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate	114214-73-2	97%	5g	$748	2021-08-06
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Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate Suppliers

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:114214-73-2)1-Boc-3-(aMinoMethyl)-3-hydroxypyrrolidine

Order Number:sfd7326

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:34

Price ($):discuss personally

Email:[email protected]

Product Official Link

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Related Categories

Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidine carboxylic acids and derivatives Pyrrolidine carboxylic acids

Additional information on Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate

Comprehensive Overview of Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate (CAS No. 114214-73-2)

Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate (CAS No. 114214-73-2) is a versatile organic compound widely utilized in pharmaceutical research, agrochemical development, and specialty chemical synthesis. This pyrrolidine derivative features a unique combination of functional groups, including a tert-butyl carbamate and a hydroxyl-aminomethyl moiety, making it a valuable intermediate for drug discovery and fine chemical applications. Its molecular structure (C10H20N2O3) offers excellent reactivity for further modifications, aligning with modern trends in green chemistry and sustainable synthesis.

In recent years, the demand for pyrrolidine-based building blocks like Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate has surged due to their role in developing biologically active molecules. Researchers frequently search for "CAS 114214-73-2 solubility," "pyrrolidine derivatives in drug design," and "tert-butyl protection strategies," reflecting its importance in medicinal chemistry. The compound's chiral center at the 3-position also makes it relevant for asymmetric synthesis, a hot topic in academic and industrial R&D.

The synthesis of Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate typically involves multi-step reactions, including Boc protection and reductive amination, with yields optimized through catalytic methods. Analytical techniques such as HPLC, NMR, and mass spectrometry confirm its high purity (>98%), a critical factor for pharmaceutical applications. Users often inquire about "storage conditions for CAS 114214-73-2" – this compound is best preserved under inert gas at 2–8°C to prevent degradation.

Beyond pharmaceuticals, Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate finds applications in material science, particularly in designing functional polymers and ligands for catalysis. Its hydrogen-bonding capacity enables molecular self-assembly, a property explored in nanotechnology. Current discussions in scientific forums highlight its potential in "targeted drug delivery systems" and "enzyme mimicry," addressing the growing interest in precision medicine.

From a regulatory perspective, Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate complies with major chemical inventories (e.g., REACH, DSL), though proper risk assessment is recommended for industrial-scale handling. Environmental studies confirm its low bioaccumulation potential, aligning with the industry's shift toward eco-friendly intermediates. FAQs like "Is CAS 114214-73-2 biodegradable?" underscore the market's focus on environmental impact.

Future research directions for this compound include exploring its structure-activity relationships in GPCR-targeted drugs and optimizing continuous flow synthesis for scalable production. With the rise of AI-assisted molecular design, computational studies on Tert-butyl 3-(aminomethyl)-3-hydroxypyrrolidine-1-carboxylate could accelerate its adoption in next-generation therapeutics, answering trending queries about "machine learning in chemical discovery."

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