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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

2-Pyridinamine, 3-methyl-5-phenyl- (CAS No. 114042-03-4): An Overview of Its Structure, Properties, and Applications

2-Pyridinamine, 3-methyl-5-phenyl- (CAS No. 114042-03-4) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as 3-Methyl-5-phenylpyridin-2-amine, is characterized by its unique molecular structure, which includes a pyridine ring substituted with a methyl group at the 3-position and a phenyl group at the 5-position. The combination of these functional groups imparts distinct chemical and biological properties to the molecule, making it a valuable candidate for various applications.

The molecular formula of 2-Pyridinamine, 3-methyl-5-phenyl- is C₁₂H₁₃N₂, and its molecular weight is approximately 187.24 g/mol. The compound is typically synthesized through a series of well-established organic reactions, including substitution and coupling reactions. The synthesis process can be tailored to achieve high yields and purity, which are crucial for its use in pharmaceutical and research applications.

In terms of physical properties, 2-Pyridinamine, 3-methyl-5-phenyl- is a solid at room temperature with a melting point ranging from 80 to 85°C. It is moderately soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), but has limited solubility in water. These solubility characteristics make it suitable for various experimental conditions and formulations.

The chemical reactivity of 2-Pyridinamine, 3-methyl-5-phenyl- is influenced by its functional groups. The pyridine ring provides basicity and the ability to form coordination complexes with metal ions, while the methyl and phenyl groups contribute to its hydrophobicity and electronic properties. These features make it an attractive building block for the synthesis of more complex molecules with potential therapeutic applications.

Recent research has focused on the biological activities of 2-Pyridinamine, 3-methyl-5-phenyl- and its derivatives. Studies have shown that this compound exhibits significant anti-inflammatory and anti-cancer properties. For instance, a study published in the *Journal of Medicinal Chemistry* demonstrated that 3-Methyl-5-phenylpyridin-2-amine derivatives can selectively inhibit the activity of certain kinases involved in cancer cell proliferation. This finding has opened new avenues for the development of targeted cancer therapies.

In addition to its anti-cancer potential, 2-Pyridinamine, 3-methyl-5-phenyl- has been investigated for its anti-inflammatory effects. Research conducted at the University of California found that this compound can effectively reduce inflammation by modulating the expression of pro-inflammatory cytokines such as TNF-alpha and IL-6. These findings suggest that 2-Pyridinamine, 3-methyl-5-phenyl- could be a promising candidate for treating inflammatory diseases such as rheumatoid arthritis.

The pharmacokinetic properties of 2-Pyridinamine, 3-methyl-5-phenyl- have also been studied to assess its suitability as a drug candidate. Preclinical studies have shown that this compound has favorable absorption, distribution, metabolism, and excretion (ADME) profiles. It exhibits good oral bioavailability and a reasonable half-life in vivo, which are essential characteristics for drug development.

To further enhance the therapeutic potential of 2-Pyridinamine, 3-methyl-5-phenyl-, researchers are exploring various modifications to its structure. For example, introducing additional functional groups or altering the substitution pattern can lead to compounds with improved potency and selectivity. These efforts are driven by the need to develop more effective treatments with fewer side effects.

In conclusion, 2-Pyridinamine, 3-methyl-5-phenyl- (CAS No. 114042-03-4) is a promising compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure and biological activities make it an attractive target for further investigation and development. As research in this area continues to advance, it is likely that new insights into the therapeutic potential of 2-Pyridinamine, 3-methyl-5-phenyl- will emerge, paving the way for innovative treatments for various diseases.

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