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N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide (CAS 1139453-98-7): A Comprehensive Overview

N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide (CAS 1139453-98-7) is a specialized chemical compound that has garnered significant attention in pharmaceutical and biochemical research. This compound, often referred to by its systematic name, features a unique molecular structure combining a methylpiperazine moiety with a nitrophenyl group, making it a subject of interest for drug discovery and development.

The compound's molecular formula is C₁₄H₂₀N₄O₃, with a molecular weight of 292.34 g/mol. Its structure includes a methylpiperazine ring, which is known for its role in enhancing bioavailability and modulating pharmacokinetic properties in drug molecules. The presence of the nitrophenyl group adds to its potential reactivity and utility in synthetic chemistry applications.

Researchers have explored N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide for its potential applications in medicinal chemistry. The compound's structural features suggest it could serve as a building block for the synthesis of more complex molecules, particularly those targeting neurological and metabolic disorders. Its methylpiperazine component is often found in compounds with psychoactive or CNS-modulating effects, though this specific derivative is primarily used in research settings.

In recent years, the demand for N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide has increased due to its potential role in developing novel therapeutic agents. The compound's ability to interact with various biological targets makes it a valuable tool for studying receptor-ligand interactions and signal transduction pathways. Its nitrophenyl group, in particular, contributes to its electron-withdrawing properties, which can influence binding affinities and metabolic stability.

The synthesis of N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide typically involves multi-step organic reactions, starting with readily available precursors. Researchers have optimized these synthetic routes to improve yield and purity, making the compound more accessible for laboratory use. Its stability under standard storage conditions (typically at room temperature in a dry environment) further enhances its practicality for research applications.

From a safety perspective, N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide should be handled with standard laboratory precautions. While not classified as highly hazardous, proper personal protective equipment (PPE) including gloves and safety glasses is recommended when working with this compound. Material Safety Data Sheets (MSDS) provide detailed handling instructions for researchers.

The market for specialized chemical compounds like N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide has grown significantly with advancements in drug discovery technologies. Pharmaceutical companies and research institutions are increasingly seeking such building blocks for high-throughput screening and combinatorial chemistry approaches. The compound's unique structure makes it particularly valuable for fragment-based drug design strategies.

Analytical characterization of N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide typically involves techniques such as NMR spectroscopy, mass spectrometry, and HPLC. These methods confirm the compound's identity and purity, which are critical for research applications. The nitrophenyl group provides a strong chromophore that facilitates UV detection in analytical methods.

Future research directions for N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide may explore its potential as a precursor for more complex pharmaceutical intermediates. The compound's modular structure allows for various chemical modifications, enabling the creation of diverse molecular libraries for biological screening. Its methylpiperazine component, in particular, offers opportunities for structure-activity relationship studies.

For researchers interested in obtaining N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide (CAS 1139453-98-7), several specialty chemical suppliers offer the compound in various quantities and purity grades. When sourcing this material, it's important to verify certificates of analysis and consider the supplier's reputation for quality and reliability in the research community.

• 88950-85-0(Glycinamide, glycylglycyl-N-(4-nitrophenyl)-, monohydrochloride (9CI))
• 318280-95-4(N-(2-Piperazino-acetyl)-N-methylaniline)
• 262368-30-9(N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide)
• 1022128-82-0(1-(4-Aminophenyl)piperazin-2-one)
• 88452-42-0(1,4-Butanediaminium, N1,N1,N4,N4-tetramethyl-N1,N4-bis[2-[(4-nitrophenyl)amino]-2-oxoethyl]-, chloride (1:2))
• 159450-62-1(1-Piperazineacetamide,4-methyl-N,N-diphenyl-)
• 1160097-94-8(1-(4-aminophenyl)-4-ethyl-2-Piperazinone)
• 90917-86-5(1-Phenylpiperazin-2-one)
• 1160097-93-7(4-ethyl-1-(4-nitrophenyl)-2-Piperazinone)
• 867166-73-2(1-(4-Nitrophenyl)piperazin-2-one)