• 1. Design, step-economical diversity-oriented synthesis of an N-heterocyclic library containing a pyrimidine moiety: discovery of novel potential herbicidal agents
  Dong Ma,Yang Yin,Ying-Lu Chen,Yi-Tao Yan,Jun Wu RSC Adv. 2021 11 15380
• 2. Switchable solvent-controlled divergent synthesis: an efficient and regioselective approach to pyrimidine and dibenzo[b,f][1,4]oxazepine derivatives
  Jin-Peng Meng,Wan-Wan Wang,Ying-Lu Chen,Saurav Bera,Jun Wu Org. Chem. Front. 2020 7 267

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers

Introduction to 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine (CAS No. 113583-35-0)

4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine, identified by the Chemical Abstracts Service Number (CAS No.) 113583-35-0, is a significant compound in the realm of pharmaceutical and agrochemical research. This heterocyclic organic compound belongs to the pyrimidine class, characterized by a six-membered ring containing two nitrogen atoms. The presence of methoxy and methylsulfonyl functional groups imparts unique chemical properties, making it a valuable intermediate in synthetic chemistry and a potential precursor for various biologically active molecules.

The molecular structure of 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine consists of a pyrimidine core substituted with two methoxy groups at the 4- and 6-positions and a methylsulfonyl group at the 2-position. This specific arrangement enhances its reactivity and makes it a versatile building block for further chemical modifications. The compound exhibits moderate solubility in polar organic solvents, which facilitates its use in various synthetic protocols.

In recent years, 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine has garnered attention due to its role in the development of novel pharmaceutical agents. Pyrimidine derivatives are well-known for their biological activity, particularly in the inhibition of enzymes and receptors involved in cancer, inflammation, and infectious diseases. The methoxy and methylsulfonyl substituents contribute to the compound's ability to interact with biological targets, enhancing its pharmacological potential.

One of the most compelling aspects of 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine is its utility as a key intermediate in the synthesis of antiviral and anticancer compounds. Researchers have leveraged its structural framework to develop molecules that exhibit potent activity against various pathogens and tumors. For instance, derivatives of this compound have been investigated for their ability to inhibit viral proteases and reverse transcriptases, which are crucial for viral replication. Additionally, modifications to the pyrimidine core have led to the discovery of new chemotherapeutic agents that target specific enzymes overexpressed in cancer cells.

The synthesis of 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine typically involves multi-step organic reactions, starting from readily available pyrimidine precursors. The introduction of methoxy groups can be achieved through nucleophilic substitution reactions, while the addition of the methylsulfonyl group often requires oxidation followed by sulfonylation. These synthetic routes highlight the compound's importance as a synthetic intermediate and underscore its accessibility for further derivatization.

Recent advancements in computational chemistry have further enhanced the understanding of 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine's reactivity and potential applications. Molecular modeling studies have predicted new derivatives with improved pharmacokinetic properties, paving the way for more effective drug candidates. These computational approaches complement traditional experimental methods, allowing researchers to design targeted modifications with greater precision.

The agrochemical sector has also recognized the value of 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine as a precursor for herbicides and fungicides. Pyrimidine-based compounds are known for their efficacy in controlling weeds and fungal pathogens without harming crops. By incorporating this compound into synthetic strategies, scientists have developed novel agrochemicals that offer improved selectivity and environmental safety.

In conclusion, 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine (CAS No. 113583-35-0) is a multifaceted compound with broad applications in pharmaceutical and agrochemical research. Its unique structural features make it an excellent candidate for developing biologically active molecules targeting various diseases. As research continues to uncover new synthetic methodologies and computational tools, the potential uses of this compound are expected to expand further.

• 90905-46-7(4,6-Dimethoxy-2-Methylthiopyrimidine)
• 142596-22-3(Pyrimidine, 2-(ethylsulfonyl)-4,6-diphenoxy-)
• 100478-26-0(Pyrimidine, 4,6-bis(difluoromethoxy)-2-(methylsulfonyl)-)
• 137153-92-5(Pyrimidine, 5-chloro-4,6-dimethoxy-2-(methylsulfonyl)-)
• 1394162-61-8(4,6-dimethoxy-5-methyl-2-(methylsulfonyl)pyrimidine)
• 132900-07-3(4,6-dimethoxy-2-methylsulfinylpyrimidine)
• 131860-93-0(Pyrimidine, 2-(methylsulfonyl)-4-phenoxy-)
• 89466-55-7(4-Chloro-6-methoxy-2-(methylsulfonyl)pyrimidine)
• 57268-32-3(2-methanesulfonyl-4-methoxy-6-methylpyrimidine)
• 866874-06-8(PYRIMIDINE, 2-(METHYLSULFONYL)-4,6-BIS(OCTYLOXY)-)