• 1. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 2. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• 4. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 5. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477

Comprehensive Overview of 5,7-dibromo-3-iodo-1H-indazole (CAS No. 1131632-64-8): Properties, Applications, and Research Insights

5,7-dibromo-3-iodo-1H-indazole (CAS No. 1131632-64-8) is a halogen-substituted indazole derivative that has garnered significant attention in pharmaceutical and materials science research. This compound belongs to the class of heterocyclic compounds, which are widely studied for their diverse biological activities and potential applications in drug discovery. The presence of multiple halogen atoms (bromine and iodine) in its structure makes it a valuable intermediate for further chemical modifications, particularly in the development of novel small-molecule inhibitors and fluorescence probes.

In recent years, the demand for halogenated indazoles like 5,7-dibromo-3-iodo-1H-indazole has increased due to their role in medicinal chemistry and organic synthesis. Researchers are particularly interested in its potential as a building block for kinase inhibitors, which are crucial in targeted cancer therapies. The compound's unique electronic properties, attributed to the heavy halogens, also make it a candidate for optoelectronic materials, aligning with the growing trend of organic electronics research.

The synthesis of 5,7-dibromo-3-iodo-1H-indazole typically involves multi-step halogenation reactions starting from 1H-indazole precursors. Its molecular weight (exact mass: 436.77 g/mol) and lipophilicity (LogP ~3.5) are critical parameters for drug design, as these properties influence bioavailability and membrane permeability. Recent studies highlight its utility in cross-coupling reactions, such as Suzuki-Miyaura and Sonogashira couplings, which are pivotal in creating complex bioconjugates for therapeutic applications.

From an analytical chemistry perspective, 5,7-dibromo-3-iodo-1H-indazole exhibits distinct spectral signatures. Its NMR spectra (1H and 13C) show characteristic peaks for aromatic protons and carbons, while mass spectrometry confirms the isotopic patterns of bromine and iodine. These features are essential for quality control in industrial-scale production. Furthermore, the compound's crystal structure has been investigated to understand intermolecular interactions, which are relevant for cocrystal engineering—a hot topic in pharmaceutical formulation.

Beyond pharmaceuticals, 5,7-dibromo-3-iodo-1H-indazole is explored in material science for its potential in organic light-emitting diodes (OLEDs) and photovoltaic devices. The heavy-atom effect from iodine enhances spin-orbit coupling, making it a candidate for thermally activated delayed fluorescence (TADF) materials. This aligns with the global push toward sustainable energy solutions, where researchers seek efficient organic semiconductors.

In summary, 5,7-dibromo-3-iodo-1H-indazole (CAS No. 1131632-64-8) is a versatile compound with broad applications in drug discovery, catalysis, and advanced materials. Its unique structural features and reactivity profile position it as a key player in interdisciplinary research, addressing contemporary challenges in healthcare and green technology.

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