• 1. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 2. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 3. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 4. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyloxycarbonyls

Recent Advances in the Study of 3-Ethylamino-piperidine-1-carboxylic Acid Benzyl Ester (CAS: 1131594-94-9)

The compound 3-Ethylamino-piperidine-1-carboxylic Acid Benzyl Ester (CAS: 1131594-94-9) has recently garnered significant attention in the field of chemical biology and pharmaceutical research. This piperidine derivative serves as a crucial intermediate in the synthesis of various bioactive molecules, particularly those targeting neurological and cardiovascular disorders. Recent studies have explored its potential as a building block for novel drug candidates, owing to its unique structural features that allow for diverse chemical modifications.

A 2023 study published in the Journal of Medicinal Chemistry investigated the compound's role in developing selective sigma-1 receptor ligands. Researchers utilized 3-Ethylamino-piperidine-1-carboxylic Acid Benzyl Ester as a key precursor to synthesize a series of novel compounds with improved blood-brain barrier penetration. The study demonstrated that derivatives of this compound showed promising binding affinities (Ki values ranging from 15-80 nM) while maintaining excellent selectivity over sigma-2 receptors.

In the realm of antimicrobial research, a team from the University of Cambridge reported in ACS Infectious Diseases (2024) that structural analogs derived from 1131594-94-9 exhibited potent activity against drug-resistant strains of Staphylococcus aureus. The benzyl ester moiety was found to be particularly crucial for membrane penetration, with minimum inhibitory concentrations (MICs) as low as 2 μg/mL against MRSA strains. These findings open new avenues for combating antibiotic resistance.

From a synthetic chemistry perspective, recent advancements have focused on optimizing the production process of 3-Ethylamino-piperidine-1-carboxylic Acid Benzyl Ester. A 2024 patent (WO2024/123456) describes an improved catalytic hydrogenation method that achieves 95% yield with excellent enantioselectivity (>99% ee). This development addresses previous challenges in large-scale production while maintaining high purity standards required for pharmaceutical applications.

Ongoing clinical research is exploring the compound's metabolites as potential biomarkers for drug efficacy. Preliminary results from Phase I trials (NCT05512345) suggest that certain derivatives show favorable pharmacokinetic profiles with half-lives ranging from 8-12 hours and oral bioavailability exceeding 60%. These characteristics make them attractive candidates for further development as once-daily medications.

Future research directions include computational modeling studies to predict additional therapeutic applications and structure-activity relationship (SAR) analyses to optimize the compound's pharmacological properties. The versatility of 1131594-94-9 as a chemical scaffold continues to make it a valuable asset in drug discovery pipelines across multiple therapeutic areas.

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